Impact of Hormone Replacement Therapy on Risk of Ovarian Cancer in Postmenopausal Women with De Novo Endometriosis or a History of Endometriosis
The effect of hormone replacement therapy (HRT) on the malignant transformation of postmenopausal endometriosis remains unclear. This study aimed to investigate the impact of HRT on ovarian cancer occurrence in postmenopausal women with de novo endometriosis or a history of endometriosis. A total of...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/6/1708 |
| _version_ | 1797612982400712704 |
|---|---|
| author | Hee Joong Lee Banghyun Lee Hangseok Choi Taehee Kim Yejeong Kim Yong Beom Kim |
| author_facet | Hee Joong Lee Banghyun Lee Hangseok Choi Taehee Kim Yejeong Kim Yong Beom Kim |
| author_sort | Hee Joong Lee |
| collection | DOAJ |
| description | The effect of hormone replacement therapy (HRT) on the malignant transformation of postmenopausal endometriosis remains unclear. This study aimed to investigate the impact of HRT on ovarian cancer occurrence in postmenopausal women with de novo endometriosis or a history of endometriosis. A total of 10,304 women that received HRT (the HRT group) and 10,304 that did not (the control group) were selected by 1:1 matching those that met the study criteria. Incidences of ovarian cancer (0.3% in the HRT group and 0.5% in the control group) and cumulative incidence rates of ovarian cancer were similar in the two groups. The overall mean duration of HRT was 1.4 ± 2.2 years, but the duration of HRT in women with ovarian cancer was 2.2 ± 2.9 years. After adjusting for co-variables, receipt of HRT, duration of HRT, combined use of estrogen and progesterone, and tibolone were not found to be risk factors for ovarian cancer. However, the use of estrogen alone was found to be a significant risk factor for ovarian cancer (HR 2.898; 95% CI 1.251–6.715; <i>p</i> = 0.013). With the exception of HRT using estrogen alone, HRT did not increase the risk of ovarian cancer in postmenopausal women with a history of endometriosis or de novo endometriosis. |
| first_indexed | 2024-03-11T06:49:31Z |
| format | Article |
| id | doaj.art-50c73ba5ce594c22866e370a04973f4d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T06:49:31Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-50c73ba5ce594c22866e370a04973f4d2023-11-17T10:06:08ZengMDPI AGCancers2072-66942023-03-01156170810.3390/cancers15061708Impact of Hormone Replacement Therapy on Risk of Ovarian Cancer in Postmenopausal Women with De Novo Endometriosis or a History of EndometriosisHee Joong Lee0Banghyun Lee1Hangseok Choi2Taehee Kim3Yejeong Kim4Yong Beom Kim5Department of Obstetrics & Gynecology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu-si 11765, Gyeonggi-do, Republic of KoreaDepartment of Obstetrics and Gynecology, Inha University Hospital, College of Medicine, Inha University, 27, Inhang-ro, Sinheung-dong, Jung-gu, Incheon 22332, Republic of KoreaMedical Science Research Center, College of Medicine, Korea University, 73, Goryeodae-ro, Seongbuk-gu, Seoul 02841, Republic of KoreaDepartment of Obstetrics and Gynecology, Inha University Hospital, College of Medicine, Inha University, 27, Inhang-ro, Sinheung-dong, Jung-gu, Incheon 22332, Republic of KoreaDepartment of Obstetrics and Gynecology, Inha University Hospital, College of Medicine, Inha University, 27, Inhang-ro, Sinheung-dong, Jung-gu, Incheon 22332, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, 82, Gumi-ro 173 beon-gil, Bundang-gu, Seongnam-si 13620, Gyeonggi-do, Republic of KoreaThe effect of hormone replacement therapy (HRT) on the malignant transformation of postmenopausal endometriosis remains unclear. This study aimed to investigate the impact of HRT on ovarian cancer occurrence in postmenopausal women with de novo endometriosis or a history of endometriosis. A total of 10,304 women that received HRT (the HRT group) and 10,304 that did not (the control group) were selected by 1:1 matching those that met the study criteria. Incidences of ovarian cancer (0.3% in the HRT group and 0.5% in the control group) and cumulative incidence rates of ovarian cancer were similar in the two groups. The overall mean duration of HRT was 1.4 ± 2.2 years, but the duration of HRT in women with ovarian cancer was 2.2 ± 2.9 years. After adjusting for co-variables, receipt of HRT, duration of HRT, combined use of estrogen and progesterone, and tibolone were not found to be risk factors for ovarian cancer. However, the use of estrogen alone was found to be a significant risk factor for ovarian cancer (HR 2.898; 95% CI 1.251–6.715; <i>p</i> = 0.013). With the exception of HRT using estrogen alone, HRT did not increase the risk of ovarian cancer in postmenopausal women with a history of endometriosis or de novo endometriosis.https://www.mdpi.com/2072-6694/15/6/1708endometriosishormone replacement therapyovarian cancerpost-menopause |
| spellingShingle | Hee Joong Lee Banghyun Lee Hangseok Choi Taehee Kim Yejeong Kim Yong Beom Kim Impact of Hormone Replacement Therapy on Risk of Ovarian Cancer in Postmenopausal Women with De Novo Endometriosis or a History of Endometriosis Cancers endometriosis hormone replacement therapy ovarian cancer post-menopause |
| title | Impact of Hormone Replacement Therapy on Risk of Ovarian Cancer in Postmenopausal Women with De Novo Endometriosis or a History of Endometriosis |
| title_full | Impact of Hormone Replacement Therapy on Risk of Ovarian Cancer in Postmenopausal Women with De Novo Endometriosis or a History of Endometriosis |
| title_fullStr | Impact of Hormone Replacement Therapy on Risk of Ovarian Cancer in Postmenopausal Women with De Novo Endometriosis or a History of Endometriosis |
| title_full_unstemmed | Impact of Hormone Replacement Therapy on Risk of Ovarian Cancer in Postmenopausal Women with De Novo Endometriosis or a History of Endometriosis |
| title_short | Impact of Hormone Replacement Therapy on Risk of Ovarian Cancer in Postmenopausal Women with De Novo Endometriosis or a History of Endometriosis |
| title_sort | impact of hormone replacement therapy on risk of ovarian cancer in postmenopausal women with de novo endometriosis or a history of endometriosis |
| topic | endometriosis hormone replacement therapy ovarian cancer post-menopause |
| url | https://www.mdpi.com/2072-6694/15/6/1708 |
| work_keys_str_mv | AT heejoonglee impactofhormonereplacementtherapyonriskofovariancancerinpostmenopausalwomenwithdenovoendometriosisorahistoryofendometriosis AT banghyunlee impactofhormonereplacementtherapyonriskofovariancancerinpostmenopausalwomenwithdenovoendometriosisorahistoryofendometriosis AT hangseokchoi impactofhormonereplacementtherapyonriskofovariancancerinpostmenopausalwomenwithdenovoendometriosisorahistoryofendometriosis AT taeheekim impactofhormonereplacementtherapyonriskofovariancancerinpostmenopausalwomenwithdenovoendometriosisorahistoryofendometriosis AT yejeongkim impactofhormonereplacementtherapyonriskofovariancancerinpostmenopausalwomenwithdenovoendometriosisorahistoryofendometriosis AT yongbeomkim impactofhormonereplacementtherapyonriskofovariancancerinpostmenopausalwomenwithdenovoendometriosisorahistoryofendometriosis |