Proteomic Discovery of VEEV E2-Host Partner Interactions Identifies GRP78 Inhibitor HA15 as a Potential Therapeutic for Alphavirus Infections

Proteomic Discovery of VEEV E2-Host Partner Interactions Identifies GRP78 Inhibitor HA15 as a Potential Therapeutic for Alphavirus Infections

Alphaviruses are a genus of the <i>Togaviridae</i> family and are widely distributed across the globe. Venezuelan equine encephalitis virus (VEEV) and eastern equine encephalitis virus (EEEV), cause encephalitis and neurological sequelae while chikungunya virus (CHIKV) and Sindbis virus...

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Bibliographic Details
Main Authors: Michael D. Barrera, Victoria Callahan, Ivan Akhrymuk, Nishank Bhalla, Weidong Zhou, Catherine Campbell, Aarthi Narayanan, Kylene Kehn-Hall
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pathogens
Subjects:
E2
glycoprotein
GRP78
alphavirus
therapeutic
proteomics
Online Access:https://www.mdpi.com/2076-0817/10/3/283

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