Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis

Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis

Abstract Hepatocellular carcinoma (HCC) is a deadly malignancy with high genetic heterogeneity. TP53 mutation and c-MET activation are frequent events in human HCCs. Here, we discovered that the simultaneous mutations in TP53 and activation of c-MET occur in ~20% of human HCCs, and these patients sh...

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Bibliographic Details
Main Authors: Yi Zhou, Guofei Cui, Hongwei Xu, Joanne Chun, Doris Yang, Zheng Zhang, Lihui Yang, Jingxiao Wang, Meijuan Wan, Diego F. Calvisi, Shumei Lin, Xin Chen, Haichuan Wang
Format: Article
Language:English
Published: Nature Publishing Group 2023-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05958-y

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