DYNAMIC OF INTESTINAL PERMEABILITY IN CANCER PATIENTS DURING PERIOPERATIVE PERIOD
Intestinal mucosa is a barrier, preventing bacteria and it’s derivate from penetrating to organism, where it triggers inflammation. In this study the dynamic of intestinal permeability in cancer and cardio surgery patients during perioperative period is evaluated using dual sugar test (lactulose-man...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/283 |
| _version_ | 1797875927674257408 |
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| author | A. Yu. Karpenko D. S. Tsvetkov M. V. Kiselevsky |
| author_facet | A. Yu. Karpenko D. S. Tsvetkov M. V. Kiselevsky |
| author_sort | A. Yu. Karpenko |
| collection | DOAJ |
| description | Intestinal mucosa is a barrier, preventing bacteria and it’s derivate from penetrating to organism, where it triggers inflammation. In this study the dynamic of intestinal permeability in cancer and cardio surgery patients during perioperative period is evaluated using dual sugar test (lactulose-mannitol). Lactulose and mannitol excretion ratio is increased in group of cancer patients with postoperative complications before and after surgery. This indicates an increased intestinal permeability in these patients. Probably increased permeability cause bacterial lipopolysaccharide translocation into blood, where it induces effectors of innate immunity, leading to system inflammation reaction due to already activated immunity. According to this, evaluation of intestinal permeability can be considered as a prognostic factor of unfavorable early postoperative period in cancer patients. |
| first_indexed | 2024-04-10T01:54:11Z |
| format | Article |
| id | doaj.art-50c9ab19683d4bb0868d1c4dc765f4f3 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2024-04-10T01:54:11Z |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-50c9ab19683d4bb0868d1c4dc765f4f32023-03-13T09:05:48ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-01062732283DYNAMIC OF INTESTINAL PERMEABILITY IN CANCER PATIENTS DURING PERIOPERATIVE PERIODA. Yu. Karpenko0D. S. Tsvetkov1M. V. Kiselevsky2ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, г. МоскваФГБУ ФНКЦ ФМБА, г. МоскваФГБУ «РОНЦ им. Н.Н. Блохина» РАМН, г. МоскваIntestinal mucosa is a barrier, preventing bacteria and it’s derivate from penetrating to organism, where it triggers inflammation. In this study the dynamic of intestinal permeability in cancer and cardio surgery patients during perioperative period is evaluated using dual sugar test (lactulose-mannitol). Lactulose and mannitol excretion ratio is increased in group of cancer patients with postoperative complications before and after surgery. This indicates an increased intestinal permeability in these patients. Probably increased permeability cause bacterial lipopolysaccharide translocation into blood, where it induces effectors of innate immunity, leading to system inflammation reaction due to already activated immunity. According to this, evaluation of intestinal permeability can be considered as a prognostic factor of unfavorable early postoperative period in cancer patients.https://www.siboncoj.ru/jour/article/view/283проницаемость кишечникаонкологические больныепослеоперационные осложнения |
| spellingShingle | A. Yu. Karpenko D. S. Tsvetkov M. V. Kiselevsky DYNAMIC OF INTESTINAL PERMEABILITY IN CANCER PATIENTS DURING PERIOPERATIVE PERIOD Сибирский онкологический журнал проницаемость кишечника онкологические больные послеоперационные осложнения |
| title | DYNAMIC OF INTESTINAL PERMEABILITY IN CANCER PATIENTS DURING PERIOPERATIVE PERIOD |
| title_full | DYNAMIC OF INTESTINAL PERMEABILITY IN CANCER PATIENTS DURING PERIOPERATIVE PERIOD |
| title_fullStr | DYNAMIC OF INTESTINAL PERMEABILITY IN CANCER PATIENTS DURING PERIOPERATIVE PERIOD |
| title_full_unstemmed | DYNAMIC OF INTESTINAL PERMEABILITY IN CANCER PATIENTS DURING PERIOPERATIVE PERIOD |
| title_short | DYNAMIC OF INTESTINAL PERMEABILITY IN CANCER PATIENTS DURING PERIOPERATIVE PERIOD |
| title_sort | dynamic of intestinal permeability in cancer patients during perioperative period |
| topic | проницаемость кишечника онкологические больные послеоперационные осложнения |
| url | https://www.siboncoj.ru/jour/article/view/283 |
| work_keys_str_mv | AT ayukarpenko dynamicofintestinalpermeabilityincancerpatientsduringperioperativeperiod AT dstsvetkov dynamicofintestinalpermeabilityincancerpatientsduringperioperativeperiod AT mvkiselevsky dynamicofintestinalpermeabilityincancerpatientsduringperioperativeperiod |