Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis
Astrocytes are indispensable for central nervous system development and homeostasis. In response to injury and disease, astrocytes are integral to the immunological- and the, albeit limited, repair response. In this review, we will examine some of the functions reactive astrocytes play in the contex...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=3;spage=578;epage=582;aulast=Silva |
| _version_ | 1797645362937200640 |
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| author | Markley Silva Oliveira Junior Laura Reiche Emerson Daniele Ines Kortebi Maryam Faiz Patrick Küry |
| author_facet | Markley Silva Oliveira Junior Laura Reiche Emerson Daniele Ines Kortebi Maryam Faiz Patrick Küry |
| author_sort | Markley Silva Oliveira Junior |
| collection | DOAJ |
| description | Astrocytes are indispensable for central nervous system development and homeostasis. In response to injury and disease, astrocytes are integral to the immunological- and the, albeit limited, repair response. In this review, we will examine some of the functions reactive astrocytes play in the context of multiple sclerosis and related animal models. We will consider the heterogeneity or plasticity of astrocytes and the mechanisms by which they promote or mitigate demyelination. Finally, we will discuss a set of biomedical strategies that can stimulate astrocytes in their promyelinating response. |
| first_indexed | 2024-03-11T14:45:14Z |
| format | Article |
| id | doaj.art-50c9f1d3aa9143feb1beef23f7165fdb |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-03-11T14:45:14Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-50c9f1d3aa9143feb1beef23f7165fdb2023-10-30T11:47:16ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742024-01-0119357858210.4103/1673-5374.380879Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosisMarkley Silva Oliveira JuniorLaura ReicheEmerson DanieleInes KortebiMaryam FaizPatrick KüryAstrocytes are indispensable for central nervous system development and homeostasis. In response to injury and disease, astrocytes are integral to the immunological- and the, albeit limited, repair response. In this review, we will examine some of the functions reactive astrocytes play in the context of multiple sclerosis and related animal models. We will consider the heterogeneity or plasticity of astrocytes and the mechanisms by which they promote or mitigate demyelination. Finally, we will discuss a set of biomedical strategies that can stimulate astrocytes in their promyelinating response.http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=3;spage=578;epage=582;aulast=Silvaastrocytes; demyelination; drug-based therapies; myelin repair; oligodendrocyte precursor cells; reactive astrogliosis |
| spellingShingle | Markley Silva Oliveira Junior Laura Reiche Emerson Daniele Ines Kortebi Maryam Faiz Patrick Küry Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis Neural Regeneration Research astrocytes; demyelination; drug-based therapies; myelin repair; oligodendrocyte precursor cells; reactive astrogliosis |
| title | Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis |
| title_full | Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis |
| title_fullStr | Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis |
| title_full_unstemmed | Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis |
| title_short | Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis |
| title_sort | star power harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis |
| topic | astrocytes; demyelination; drug-based therapies; myelin repair; oligodendrocyte precursor cells; reactive astrogliosis |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=3;spage=578;epage=582;aulast=Silva |
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