Pseudogenes in Cancer: State of the Art
Pseudogenes are duplicates of protein-coding genes that have accumulated multiple detrimental alterations, rendering them unable to produce the protein they encode. Initially disregarded as “junk DNA” due to their perceived lack of functionality, research on their biological roles has been hindered...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/16/4024 |
| _version_ | 1797585238498476032 |
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| author | Arturo Kenzuke Nakamura-García Jesús Espinal-Enríquez |
| author_facet | Arturo Kenzuke Nakamura-García Jesús Espinal-Enríquez |
| author_sort | Arturo Kenzuke Nakamura-García |
| collection | DOAJ |
| description | Pseudogenes are duplicates of protein-coding genes that have accumulated multiple detrimental alterations, rendering them unable to produce the protein they encode. Initially disregarded as “junk DNA” due to their perceived lack of functionality, research on their biological roles has been hindered by this assumption. Nevertheless, recent focus has shifted towards these molecules due to their abnormal expression in cancer phenotypes. In this review, our objective is to provide a thorough overview of the current understanding of pseudogene formation, the mechanisms governing their expression, and the roles they may play in promoting tumorigenesis. |
| first_indexed | 2024-03-11T00:04:16Z |
| format | Article |
| id | doaj.art-50ca6088cf694c4682cf3bb09ef0734a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T00:04:16Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-50ca6088cf694c4682cf3bb09ef0734a2023-11-19T00:32:02ZengMDPI AGCancers2072-66942023-08-011516402410.3390/cancers15164024Pseudogenes in Cancer: State of the ArtArturo Kenzuke Nakamura-García0Jesús Espinal-Enríquez1National Institute of Genomic Medicine, Mexico City 14610, MexicoNational Institute of Genomic Medicine, Mexico City 14610, MexicoPseudogenes are duplicates of protein-coding genes that have accumulated multiple detrimental alterations, rendering them unable to produce the protein they encode. Initially disregarded as “junk DNA” due to their perceived lack of functionality, research on their biological roles has been hindered by this assumption. Nevertheless, recent focus has shifted towards these molecules due to their abnormal expression in cancer phenotypes. In this review, our objective is to provide a thorough overview of the current understanding of pseudogene formation, the mechanisms governing their expression, and the roles they may play in promoting tumorigenesis.https://www.mdpi.com/2072-6694/15/16/4024pseudogenegene expression regulationtumorigenesis |
| spellingShingle | Arturo Kenzuke Nakamura-García Jesús Espinal-Enríquez Pseudogenes in Cancer: State of the Art Cancers pseudogene gene expression regulation tumorigenesis |
| title | Pseudogenes in Cancer: State of the Art |
| title_full | Pseudogenes in Cancer: State of the Art |
| title_fullStr | Pseudogenes in Cancer: State of the Art |
| title_full_unstemmed | Pseudogenes in Cancer: State of the Art |
| title_short | Pseudogenes in Cancer: State of the Art |
| title_sort | pseudogenes in cancer state of the art |
| topic | pseudogene gene expression regulation tumorigenesis |
| url | https://www.mdpi.com/2072-6694/15/16/4024 |
| work_keys_str_mv | AT arturokenzukenakamuragarcia pseudogenesincancerstateoftheart AT jesusespinalenriquez pseudogenesincancerstateoftheart |