Are patients with eosinophilic esophagitis treated at an academic hospital comparable to a patient from a population‐based cohort? Not in Denmark
Abstract Background and Aim Little are known about differences in eosinophilic esophagitis (EoE) patients in the general population compared with patients treated at academic hospitals. This might affect the generalizability of study results. The aims of the study were to compare clinical features,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | JGH Open |
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| Online Access: | https://doi.org/10.1002/jgh3.12952 |
| _version_ | 1827856906586161152 |
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| author | Dorte Melgaard Inger B Andersen Line T Frandsen Christian Mortensen Line E M Hansen Anne L Krarup |
| author_facet | Dorte Melgaard Inger B Andersen Line T Frandsen Christian Mortensen Line E M Hansen Anne L Krarup |
| author_sort | Dorte Melgaard |
| collection | DOAJ |
| description | Abstract Background and Aim Little are known about differences in eosinophilic esophagitis (EoE) patients in the general population compared with patients treated at academic hospitals. This might affect the generalizability of study results. The aims of the study were to compare clinical features, and complications of EoE between patients from a population‐based cohort (DanEoE) and patients from an academic hospital cohort in Copenhagen (EoE‐Cph). Methods The DanEoE cohort is a population‐ and register‐based cohort including all 236 adult EoE patients diagnosed in the North Denmark Region in 2007–2017 previously described in detail. The new EoE‐Cph cohort consists of 245 consecutively referred adult patients to a dedicated EoE center in an Academic Hospital in the Danish capital in 2013–2020. Data were collected from medical registries and medical files. Results Patients in the academic cohort were at symptom debut 12 (SD 16) years younger (P = 0.001). At the time of diagnosis they were 5.4 (SD 15) years younger (P < 0.001). Where Gastro‐esophageal reflux disease (GORD) was present in one‐third of the population‐based cohort, this was only observed in 14% of the EoE‐Cph group (P < 0.05). Food bolus obstruction before diagnosis was 24% less common in the EoE‐Cph patients (P < 0.001). Conclusion Results indicated that EoE patients referred to a Danish EoE center is a selected subgroup with disease debut at a younger age, less comorbid GORD, and rarely food bolus obstruction before diagnosis. This suggests that study results from academic hospitals might not have generalizability to the average EoE patient in a population. |
| first_indexed | 2024-03-12T12:32:49Z |
| format | Article |
| id | doaj.art-50ca6b4c3eed4858823e0fca6ff8b0f4 |
| institution | Directory Open Access Journal |
| issn | 2397-9070 |
| language | English |
| last_indexed | 2024-03-12T12:32:49Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj.art-50ca6b4c3eed4858823e0fca6ff8b0f42023-08-29T07:34:25ZengWileyJGH Open2397-90702023-08-017857257810.1002/jgh3.12952Are patients with eosinophilic esophagitis treated at an academic hospital comparable to a patient from a population‐based cohort? Not in DenmarkDorte Melgaard0Inger B Andersen1Line T Frandsen2Christian Mortensen3Line E M Hansen4Anne L Krarup5MechSense, Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg DenmarkGastro Unit, Medical Division Hvidovre University Hospital Copenhagen DenmarkDepartment of Gastroenterology and Hepatology Aalborg University Hospital Aalborg DenmarkGastro Unit, Medical Division Hvidovre University Hospital Copenhagen DenmarkMechSense, Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg DenmarkFaculty of Clinical Medicine Aalborg University Aalborg DenmarkAbstract Background and Aim Little are known about differences in eosinophilic esophagitis (EoE) patients in the general population compared with patients treated at academic hospitals. This might affect the generalizability of study results. The aims of the study were to compare clinical features, and complications of EoE between patients from a population‐based cohort (DanEoE) and patients from an academic hospital cohort in Copenhagen (EoE‐Cph). Methods The DanEoE cohort is a population‐ and register‐based cohort including all 236 adult EoE patients diagnosed in the North Denmark Region in 2007–2017 previously described in detail. The new EoE‐Cph cohort consists of 245 consecutively referred adult patients to a dedicated EoE center in an Academic Hospital in the Danish capital in 2013–2020. Data were collected from medical registries and medical files. Results Patients in the academic cohort were at symptom debut 12 (SD 16) years younger (P = 0.001). At the time of diagnosis they were 5.4 (SD 15) years younger (P < 0.001). Where Gastro‐esophageal reflux disease (GORD) was present in one‐third of the population‐based cohort, this was only observed in 14% of the EoE‐Cph group (P < 0.05). Food bolus obstruction before diagnosis was 24% less common in the EoE‐Cph patients (P < 0.001). Conclusion Results indicated that EoE patients referred to a Danish EoE center is a selected subgroup with disease debut at a younger age, less comorbid GORD, and rarely food bolus obstruction before diagnosis. This suggests that study results from academic hospitals might not have generalizability to the average EoE patient in a population.https://doi.org/10.1002/jgh3.12952eosinophiliaeosinophilic esophagitisesophagusgastro‐esophageal refluxpopulation‐basedregister‐based |
| spellingShingle | Dorte Melgaard Inger B Andersen Line T Frandsen Christian Mortensen Line E M Hansen Anne L Krarup Are patients with eosinophilic esophagitis treated at an academic hospital comparable to a patient from a population‐based cohort? Not in Denmark JGH Open eosinophilia eosinophilic esophagitis esophagus gastro‐esophageal reflux population‐based register‐based |
| title | Are patients with eosinophilic esophagitis treated at an academic hospital comparable to a patient from a population‐based cohort? Not in Denmark |
| title_full | Are patients with eosinophilic esophagitis treated at an academic hospital comparable to a patient from a population‐based cohort? Not in Denmark |
| title_fullStr | Are patients with eosinophilic esophagitis treated at an academic hospital comparable to a patient from a population‐based cohort? Not in Denmark |
| title_full_unstemmed | Are patients with eosinophilic esophagitis treated at an academic hospital comparable to a patient from a population‐based cohort? Not in Denmark |
| title_short | Are patients with eosinophilic esophagitis treated at an academic hospital comparable to a patient from a population‐based cohort? Not in Denmark |
| title_sort | are patients with eosinophilic esophagitis treated at an academic hospital comparable to a patient from a population based cohort not in denmark |
| topic | eosinophilia eosinophilic esophagitis esophagus gastro‐esophageal reflux population‐based register‐based |
| url | https://doi.org/10.1002/jgh3.12952 |
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