Caries Prevention Using Silver Diamine Fluoride: A 12-Month Clinical Trial
Objective: This clinical trial aimed to compare the caries-preventive effect of annual application of 38% silver diamine fluoride solution (SDF) with 5% sodium fluoride varnish (FV) to the anterior primary teeth of children. The hypothesis was that SDF was superior to FV at 1 year. Secondary objecti...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | International Dental Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0020653922002829 |
| _version_ | 1827819200093093888 |
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| author | Faith Miaomiao Zheng Iliana Gehui Yan Duangporn Duangthip Edward Chin Man Lo Sherry Shiqian Gao Chun Hung Chu |
| author_facet | Faith Miaomiao Zheng Iliana Gehui Yan Duangporn Duangthip Edward Chin Man Lo Sherry Shiqian Gao Chun Hung Chu |
| author_sort | Faith Miaomiao Zheng |
| collection | DOAJ |
| description | Objective: This clinical trial aimed to compare the caries-preventive effect of annual application of 38% silver diamine fluoride solution (SDF) with 5% sodium fluoride varnish (FV) to the anterior primary teeth of children. The hypothesis was that SDF was superior to FV at 1 year. Secondary objectives were to determine the child's cooperation and the parent's satisfaction and assess adverse effects. Method: We recruited 688 3- to 4-year-old children and randomly allocated them to receive SDF or FV (positive control) on their 6 upper anterior teeth. Tooth-surface status was recorded using the decayed, missing, and filled surfaces index. A trained observer rated the child's cooperation as “totally cooperative” or “not totally cooperative.” We used a questionnaire to determine the parent's satisfaction as “satisfied,” “neutral,” or “dissatisfied.” Adverse effects (yes/no) were evaluated 1 day and about 1 year after treatment. Results: Of the children, 434 (SDF, n = 209; FV, n = 225) completed the trial. The mean new decayed tooth surfaces developed for SDF and FV groups were 0.4 ± 1.5 and 0.4 ± 1.3, respectively (P = .65). Child's cooperation for SDF and FV therapy was 71% (244/344) and 70% (241/344), respectively (P = .89). Parent's satisfaction for SDF and FV therapy was 71% (148/209) and 69% (155/225), respectively (P = .29). Adverse effects were found neither at 1 day nor at about 1 year after treatment for either treatment arm. Conclusions: SDF is not superior to FV for caries prevention in primary upper anterior teeth at 1-year follow-up. Child's cooperation and parent's satisfaction were similarly high with SDF and FV therapy at 1-year follow-up. Neither short-term nor long-term adverse effects were observed. This study is registered at ClinicalTrials.gov (NCT04399369). |
| first_indexed | 2024-03-12T01:11:44Z |
| format | Article |
| id | doaj.art-50ca74fdfd4049f2b1dec66bb9a9b3ee |
| institution | Directory Open Access Journal |
| issn | 0020-6539 |
| language | English |
| last_indexed | 2024-03-12T01:11:44Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Dental Journal |
| spelling | doaj.art-50ca74fdfd4049f2b1dec66bb9a9b3ee2023-09-14T04:52:19ZengElsevierInternational Dental Journal0020-65392023-10-01735667673Caries Prevention Using Silver Diamine Fluoride: A 12-Month Clinical TrialFaith Miaomiao Zheng0Iliana Gehui Yan1Duangporn Duangthip2Edward Chin Man Lo3Sherry Shiqian Gao4Chun Hung Chu5Faculty of Dentistry, The University of Hong Kong, Hong Kong, ChinaFaculty of Dentistry, The University of Hong Kong, Hong Kong, ChinaFaculty of Dentistry, The University of Hong Kong, Hong Kong, ChinaFaculty of Dentistry, The University of Hong Kong, Hong Kong, ChinaFaculty of Dentistry, The University of Hong Kong, Hong Kong, China; Department of Stomatology, School of Medicine, Xiamen University, Xiamen, China; Corresponding author. Department of Stomatology, School of Medicine, Xiamen University, Xiamen, China.Faculty of Dentistry, The University of Hong Kong, Hong Kong, China; Corresponding author. Faculty of Dentistry, The University of Hong Kong, Hong Kong 999077, China.Objective: This clinical trial aimed to compare the caries-preventive effect of annual application of 38% silver diamine fluoride solution (SDF) with 5% sodium fluoride varnish (FV) to the anterior primary teeth of children. The hypothesis was that SDF was superior to FV at 1 year. Secondary objectives were to determine the child's cooperation and the parent's satisfaction and assess adverse effects. Method: We recruited 688 3- to 4-year-old children and randomly allocated them to receive SDF or FV (positive control) on their 6 upper anterior teeth. Tooth-surface status was recorded using the decayed, missing, and filled surfaces index. A trained observer rated the child's cooperation as “totally cooperative” or “not totally cooperative.” We used a questionnaire to determine the parent's satisfaction as “satisfied,” “neutral,” or “dissatisfied.” Adverse effects (yes/no) were evaluated 1 day and about 1 year after treatment. Results: Of the children, 434 (SDF, n = 209; FV, n = 225) completed the trial. The mean new decayed tooth surfaces developed for SDF and FV groups were 0.4 ± 1.5 and 0.4 ± 1.3, respectively (P = .65). Child's cooperation for SDF and FV therapy was 71% (244/344) and 70% (241/344), respectively (P = .89). Parent's satisfaction for SDF and FV therapy was 71% (148/209) and 69% (155/225), respectively (P = .29). Adverse effects were found neither at 1 day nor at about 1 year after treatment for either treatment arm. Conclusions: SDF is not superior to FV for caries prevention in primary upper anterior teeth at 1-year follow-up. Child's cooperation and parent's satisfaction were similarly high with SDF and FV therapy at 1-year follow-up. Neither short-term nor long-term adverse effects were observed. This study is registered at ClinicalTrials.gov (NCT04399369).http://www.sciencedirect.com/science/article/pii/S0020653922002829CariesChildrenSilver diamine fluoridePreventionEarly childhoodOral health |
| spellingShingle | Faith Miaomiao Zheng Iliana Gehui Yan Duangporn Duangthip Edward Chin Man Lo Sherry Shiqian Gao Chun Hung Chu Caries Prevention Using Silver Diamine Fluoride: A 12-Month Clinical Trial International Dental Journal Caries Children Silver diamine fluoride Prevention Early childhood Oral health |
| title | Caries Prevention Using Silver Diamine Fluoride: A 12-Month Clinical Trial |
| title_full | Caries Prevention Using Silver Diamine Fluoride: A 12-Month Clinical Trial |
| title_fullStr | Caries Prevention Using Silver Diamine Fluoride: A 12-Month Clinical Trial |
| title_full_unstemmed | Caries Prevention Using Silver Diamine Fluoride: A 12-Month Clinical Trial |
| title_short | Caries Prevention Using Silver Diamine Fluoride: A 12-Month Clinical Trial |
| title_sort | caries prevention using silver diamine fluoride a 12 month clinical trial |
| topic | Caries Children Silver diamine fluoride Prevention Early childhood Oral health |
| url | http://www.sciencedirect.com/science/article/pii/S0020653922002829 |
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