Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T α-synuclein mutation

Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T α-synuclein mutation

<p>Abstract</p> <p>Background</p> <p>The A53T mutation in the <it>α-synuclein </it>gene causes autosomal-dominant Lewy body Parkinson's disease (PD). Cultured cell models have linked this mutation to increased cell macroautophagy, although evidence of e...

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Bibliographic Details
Main Authors: Huang Yue, Chegini Fariba, Chua Germaine, Murphy Karen, Gai Weiping, Halliday Glenda M
Format: Article
Language:English
Published: BMC 2012-01-01
Series:Translational Neurodegeneration
Subjects:
α-synuclein
macroautophagy
Parkinson's disease
Online Access:http://www.translationalneurodegeneration.com/content/1/1/2

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