Mesenchymal Stem Cells Overexpressing Interleukin-10 Promote Neuroprotection in Experimental Acute Ischemic Stroke
Interleukin (IL)-10 is a contributing factor to neuroprotection of mesenchymal stem cell (MSC) transplantation after ischemic stroke. Our aim was to increase therapeutic effects by combining MSCs and ex vivo IL-10 gene transfer with an adeno-associated virus (AAV) vector using a rat transient middle...
Main Authors: | Masataka Nakajima, Chikako Nito, Kota Sowa, Satoshi Suda, Yasuhiro Nishiyama, Aki Nakamura-Takahashi, Yuko Nitahara-Kasahara, Kiwamu Imagawa, Tohru Hirato, Masayuki Ueda, Kazumi Kimura, Takashi Okada |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2017-09-01
|
Series: | Molecular Therapy: Methods & Clinical Development |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2329050117300803 |
Similar Items
-
Dental-Pulp Stem Cells as a Therapeutic Strategy for Ischemic Stroke
by: Chikako Nito, et al.
Published: (2022-03-01) -
Biodistribution of adeno-associated virus serotype 9 after intrathecal and intravenous delivery in mouse
by: Daniel J. Schuster, et al.
Published: (2014-06-01) -
Intravenous Rituximab in Severe Refractory Primary Focal Segmental Glomerulosclerosis
by: Wee Leng Gan, et al.
Published: (2018-10-01) -
iPSC-derived mesenchymal stem cells attenuate cerebral ischemia-reperfusion injury by inhibiting inflammatory signaling and oxidative stress
by: Masafumi Arakawa, et al.
Published: (2023-09-01) -
Recent Advances in Cell-Based Therapies for Ischemic Stroke
by: Satoshi Suda, et al.
Published: (2020-09-01)