Transcriptomic Crosstalk between Gliomas and Telencephalic Neural Stem and Progenitor Cells for Defining Heterogeneity and Targeted Signaling Pathways
Recent studies have begun to reveal surprising levels of cell diversity in the human brain, both in adults and during development. Distinctive cellular phenotypes point to complex molecular profiles, cellular hierarchies and signaling pathways in neural stem cells, progenitor cells, neuronal and gli...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/24/13211 |
| _version_ | 1797503928901828608 |
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| author | Roxana Deleanu Laura Cristina Ceafalan Anica Dricu |
| author_facet | Roxana Deleanu Laura Cristina Ceafalan Anica Dricu |
| author_sort | Roxana Deleanu |
| collection | DOAJ |
| description | Recent studies have begun to reveal surprising levels of cell diversity in the human brain, both in adults and during development. Distinctive cellular phenotypes point to complex molecular profiles, cellular hierarchies and signaling pathways in neural stem cells, progenitor cells, neuronal and glial cells. Several recent reports have suggested that neural stem and progenitor cell types found in the developing and adult brain share several properties and phenotypes with cells from brain primary tumors, such as gliomas. This transcriptomic crosstalk may help us to better understand the cell hierarchies and signaling pathways in both gliomas and the normal brain, and, by clarifying the phenotypes of cells at the origin of the tumor, to therapeutically address their most relevant signaling pathways. |
| first_indexed | 2024-03-10T03:57:22Z |
| format | Article |
| id | doaj.art-50cdb29f63904ce587c8d4a0ac8566fc |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:57:22Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-50cdb29f63904ce587c8d4a0ac8566fc2023-11-23T08:42:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0122241321110.3390/ijms222413211Transcriptomic Crosstalk between Gliomas and Telencephalic Neural Stem and Progenitor Cells for Defining Heterogeneity and Targeted Signaling PathwaysRoxana Deleanu0Laura Cristina Ceafalan1Anica Dricu2Institute for Neuroscience, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Cell Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Biochmistry, University of Medicine and Pharmacy, 710204 Craiova, RomaniaRecent studies have begun to reveal surprising levels of cell diversity in the human brain, both in adults and during development. Distinctive cellular phenotypes point to complex molecular profiles, cellular hierarchies and signaling pathways in neural stem cells, progenitor cells, neuronal and glial cells. Several recent reports have suggested that neural stem and progenitor cell types found in the developing and adult brain share several properties and phenotypes with cells from brain primary tumors, such as gliomas. This transcriptomic crosstalk may help us to better understand the cell hierarchies and signaling pathways in both gliomas and the normal brain, and, by clarifying the phenotypes of cells at the origin of the tumor, to therapeutically address their most relevant signaling pathways.https://www.mdpi.com/1422-0067/22/24/13211single-cell RNA-seqprimary cerebral tumorsgliomacancer stem-like cellshuman neural stem cellshuman neural progenitors |
| spellingShingle | Roxana Deleanu Laura Cristina Ceafalan Anica Dricu Transcriptomic Crosstalk between Gliomas and Telencephalic Neural Stem and Progenitor Cells for Defining Heterogeneity and Targeted Signaling Pathways International Journal of Molecular Sciences single-cell RNA-seq primary cerebral tumors glioma cancer stem-like cells human neural stem cells human neural progenitors |
| title | Transcriptomic Crosstalk between Gliomas and Telencephalic Neural Stem and Progenitor Cells for Defining Heterogeneity and Targeted Signaling Pathways |
| title_full | Transcriptomic Crosstalk between Gliomas and Telencephalic Neural Stem and Progenitor Cells for Defining Heterogeneity and Targeted Signaling Pathways |
| title_fullStr | Transcriptomic Crosstalk between Gliomas and Telencephalic Neural Stem and Progenitor Cells for Defining Heterogeneity and Targeted Signaling Pathways |
| title_full_unstemmed | Transcriptomic Crosstalk between Gliomas and Telencephalic Neural Stem and Progenitor Cells for Defining Heterogeneity and Targeted Signaling Pathways |
| title_short | Transcriptomic Crosstalk between Gliomas and Telencephalic Neural Stem and Progenitor Cells for Defining Heterogeneity and Targeted Signaling Pathways |
| title_sort | transcriptomic crosstalk between gliomas and telencephalic neural stem and progenitor cells for defining heterogeneity and targeted signaling pathways |
| topic | single-cell RNA-seq primary cerebral tumors glioma cancer stem-like cells human neural stem cells human neural progenitors |
| url | https://www.mdpi.com/1422-0067/22/24/13211 |
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