| Summary: | Introduction. Periodontitis is a destructive inflammatory disease of the
tooth-supporting tissues, primarily caused by Gram-negative microorganisms.
Thus, the primary objective of cause-related initial periodontal therapy is
disruption and removal of the subgingival biofilm. Objective. The aim of this
study was to evaluate the clinical and microbiological effects of the initial
therapy in patients diagnosed with chronic periodontitis. Methods. Forty
patients with chronic periodontitis were included in the study. As a part of
the clinical assessment undertaken prior to the initial therapy, as well as
one month and three months post-therapy, plaque index, gingival index,
papilla bleeding index, probing pocket depth and clinical attachment level
were recorded. Microbiological testing was performed prior to the initial
therapy and three months after therapy. Polymerase chain reaction assays were
used to determine the presence of Porphyromonas gingivalis, Tannerella
forsythensis, Prevotella intermedia and Aggregatibacter
actinomycetemcomitans. Results. All clinical parameters were significantly
reduced after therapy. The prevalence of Aggregatibacter
actinomycetemcomitans was reduced by 22.5%, which was a statistically
significant decrease compared to the baseline. The prevalence of
Porphyromonas gingivalis, Tannerella forsythensis and Prevotella intermedia
tended to decrease after therapy; however, the difference did not reach
statistical significance. Conclusion. The results of the present study
demonstrated the beneficial effects of the initial periodontal therapy on
both the clinical and microbiological parameters. [Projekat Ministarstva
nauke Republike Srbije, br. 175075]
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