DNA methylation profiling in Trisomy 21 females with and without breast cancer

DNA methylation profiling in Trisomy 21 females with and without breast cancer

BackgroundDown Syndrome (DS) is the most common chromosome anomaly in humans and occurs due to an extra copy of chromosome 21. The malignancy profile in DS is unique, since DS patients have a low risk of developing solid tumors such as breast cancer however they are at higher risk of developing acut...

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Bibliographic Details
Main Authors: Yosra Bejaoui, Sara Alresheq, Sophie Durand, Marie Vilaire-Meunier, Louise Maillebouis, Ayman Al Haj Zen, André Mégarbané, Nady El Hajj
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Oncology
Subjects:
Down syndrome
breast cancer
DNA methylation
epigenetics
Trisomy 21
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1203483/full

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