Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses

Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses

Abstract Background Neuropathic pain is still a challenge for clinical treatment as a result of the comprehensive pathogenesis. Although emerging evidence demonstrates the pivotal role of glial cells in regulating neuropathic pain, the role of Schwann cells and their underlying mechanisms still need...

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Bibliographic Details
Main Authors: Qian Wang, Han-yang Li, Zhuo-min Ling, Gang Chen, Zhong-Ya Wei
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Neuroinflammation
Subjects:
Pannexin 1
Schwann cell
IL-6
Neuropathic pain
Inflammatory factor
Online Access:https://doi.org/10.1186/s12974-022-02603-x

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