Rat Models of Vocal Deficits in Parkinson’s Disease
Parkinson’s disease (PD) is a progressive, degenerative disorder that affects 10 million people worldwide. More than 90% of individuals with PD develop hypokinetic dysarthria, a motor speech disorder that impairs vocal communication and quality of life. Despite the prevalence of vocal deficits in th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/7/925 |
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| author | Maryann N. Krasko Jesse D. Hoffmeister Nicole E. Schaen-Heacock Jacob M. Welsch Cynthia A. Kelm-Nelson Michelle R. Ciucci |
| author_facet | Maryann N. Krasko Jesse D. Hoffmeister Nicole E. Schaen-Heacock Jacob M. Welsch Cynthia A. Kelm-Nelson Michelle R. Ciucci |
| author_sort | Maryann N. Krasko |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a progressive, degenerative disorder that affects 10 million people worldwide. More than 90% of individuals with PD develop hypokinetic dysarthria, a motor speech disorder that impairs vocal communication and quality of life. Despite the prevalence of vocal deficits in this population, very little is known about the pathological mechanisms underlying this aspect of disease. As such, effective treatment options are limited. Rat models have provided unique insights into the disease-specific mechanisms of vocal deficits in PD. This review summarizes recent studies investigating vocal deficits in 6-hydroxydopamine (6-OHDA), alpha-synuclein overexpression, <i>DJ1-/-</i>, and <i>Pink1-/-</i> rat models of PD. Model-specific changes to rat ultrasonic vocalization (USV), and the effects of exercise and pharmacologic interventions on USV production in these models are discussed. |
| first_indexed | 2024-03-10T09:43:58Z |
| format | Article |
| id | doaj.art-50d4a32ac89e4699a705f61bd4b45282 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T09:43:58Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-50d4a32ac89e4699a705f61bd4b452822023-11-22T03:20:51ZengMDPI AGBrain Sciences2076-34252021-07-0111792510.3390/brainsci11070925Rat Models of Vocal Deficits in Parkinson’s DiseaseMaryann N. Krasko0Jesse D. Hoffmeister1Nicole E. Schaen-Heacock2Jacob M. Welsch3Cynthia A. Kelm-Nelson4Michelle R. Ciucci5Department of Surgery, University of Wisconsin-Madison, Madison, WI 53792, USADepartment of Surgery, University of Wisconsin-Madison, Madison, WI 53792, USADepartment of Surgery, University of Wisconsin-Madison, Madison, WI 53792, USADepartment of Surgery, University of Wisconsin-Madison, Madison, WI 53792, USADepartment of Surgery, University of Wisconsin-Madison, Madison, WI 53792, USADepartment of Surgery, University of Wisconsin-Madison, Madison, WI 53792, USAParkinson’s disease (PD) is a progressive, degenerative disorder that affects 10 million people worldwide. More than 90% of individuals with PD develop hypokinetic dysarthria, a motor speech disorder that impairs vocal communication and quality of life. Despite the prevalence of vocal deficits in this population, very little is known about the pathological mechanisms underlying this aspect of disease. As such, effective treatment options are limited. Rat models have provided unique insights into the disease-specific mechanisms of vocal deficits in PD. This review summarizes recent studies investigating vocal deficits in 6-hydroxydopamine (6-OHDA), alpha-synuclein overexpression, <i>DJ1-/-</i>, and <i>Pink1-/-</i> rat models of PD. Model-specific changes to rat ultrasonic vocalization (USV), and the effects of exercise and pharmacologic interventions on USV production in these models are discussed.https://www.mdpi.com/2076-3425/11/7/925Parkinson’s diseaseratultrasonic vocalizationUSValpha-synuclein6-OHDA |
| spellingShingle | Maryann N. Krasko Jesse D. Hoffmeister Nicole E. Schaen-Heacock Jacob M. Welsch Cynthia A. Kelm-Nelson Michelle R. Ciucci Rat Models of Vocal Deficits in Parkinson’s Disease Brain Sciences Parkinson’s disease rat ultrasonic vocalization USV alpha-synuclein 6-OHDA |
| title | Rat Models of Vocal Deficits in Parkinson’s Disease |
| title_full | Rat Models of Vocal Deficits in Parkinson’s Disease |
| title_fullStr | Rat Models of Vocal Deficits in Parkinson’s Disease |
| title_full_unstemmed | Rat Models of Vocal Deficits in Parkinson’s Disease |
| title_short | Rat Models of Vocal Deficits in Parkinson’s Disease |
| title_sort | rat models of vocal deficits in parkinson s disease |
| topic | Parkinson’s disease rat ultrasonic vocalization USV alpha-synuclein 6-OHDA |
| url | https://www.mdpi.com/2076-3425/11/7/925 |
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