FBXW7 in breast cancer: mechanism of action and therapeutic potential
Abstract Breast cancer is one of the frequent tumors that seriously endanger the physical and mental well-being in women. F-box and WD repeat domain-containing 7 (FBXW7) is a neoplastic repressor. Serving as a substrate recognition element for ubiquitin ligase, FBXW7 participates in the ubiquitin–pr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13046-023-02767-1 |
| _version_ | 1827632699367489536 |
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| author | Siyu Chen Ping Leng Jinlin Guo Hao Zhou |
| author_facet | Siyu Chen Ping Leng Jinlin Guo Hao Zhou |
| author_sort | Siyu Chen |
| collection | DOAJ |
| description | Abstract Breast cancer is one of the frequent tumors that seriously endanger the physical and mental well-being in women. F-box and WD repeat domain-containing 7 (FBXW7) is a neoplastic repressor. Serving as a substrate recognition element for ubiquitin ligase, FBXW7 participates in the ubiquitin–proteasome system and is typically in charge of the ubiquitination and destruction of crucial oncogenic proteins, further performing a paramount role in cell differentiation, apoptosis and metabolic processes. Low levels of FBXW7 cause abnormal stability of pertinent substrates, mutations and/or deletions in the FBXW7 gene have been reported to correlate with breast cancer malignant progression and chemoresistance. Given the lack of an effective solution to breast cancer's clinical drug resistance dilemma, elucidating FBXW7's mechanism of action could provide a theoretical basis for targeted drug exploration. Therefore, in this review, we focused on FBXW7's role in a range of breast cancer malignant behaviors and summarized the pertinent cellular targets, signaling pathways, as well as the mechanisms regulating FBXW7 expression. We also proposed novel perspectives for the exploitation of alternative therapies and specific tumor markers for breast cancer by therapeutic strategies aiming at FBXW7. |
| first_indexed | 2024-03-09T14:49:14Z |
| format | Article |
| id | doaj.art-50d4e153c4e342b5b0c774dd4a9e9f1d |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-03-09T14:49:14Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-50d4e153c4e342b5b0c774dd4a9e9f1d2023-11-26T14:34:49ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662023-09-0142111810.1186/s13046-023-02767-1FBXW7 in breast cancer: mechanism of action and therapeutic potentialSiyu Chen0Ping Leng1Jinlin Guo2Hao Zhou3Chongqing Key Laboratory of Sichuan-Chongqing Co-Construction for Diagnosisand, Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, College of Medical Technology , Chengdu University of Traditional Chinese MedicineChongqing Key Laboratory of Sichuan-Chongqing Co-Construction for Diagnosisand, Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, College of Medical Technology , Chengdu University of Traditional Chinese MedicineChongqing Key Laboratory of Sichuan-Chongqing Co-Construction for Diagnosisand, Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, College of Medical Technology , Chengdu University of Traditional Chinese MedicineChongqing Key Laboratory of Sichuan-Chongqing Co-Construction for Diagnosisand, Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, College of Medical Technology , Chengdu University of Traditional Chinese MedicineAbstract Breast cancer is one of the frequent tumors that seriously endanger the physical and mental well-being in women. F-box and WD repeat domain-containing 7 (FBXW7) is a neoplastic repressor. Serving as a substrate recognition element for ubiquitin ligase, FBXW7 participates in the ubiquitin–proteasome system and is typically in charge of the ubiquitination and destruction of crucial oncogenic proteins, further performing a paramount role in cell differentiation, apoptosis and metabolic processes. Low levels of FBXW7 cause abnormal stability of pertinent substrates, mutations and/or deletions in the FBXW7 gene have been reported to correlate with breast cancer malignant progression and chemoresistance. Given the lack of an effective solution to breast cancer's clinical drug resistance dilemma, elucidating FBXW7's mechanism of action could provide a theoretical basis for targeted drug exploration. Therefore, in this review, we focused on FBXW7's role in a range of breast cancer malignant behaviors and summarized the pertinent cellular targets, signaling pathways, as well as the mechanisms regulating FBXW7 expression. We also proposed novel perspectives for the exploitation of alternative therapies and specific tumor markers for breast cancer by therapeutic strategies aiming at FBXW7.https://doi.org/10.1186/s13046-023-02767-1FBXW7Breast cancerncRNAs regulationAngiogenesisImmune escapeDrug resistance |
| spellingShingle | Siyu Chen Ping Leng Jinlin Guo Hao Zhou FBXW7 in breast cancer: mechanism of action and therapeutic potential Journal of Experimental & Clinical Cancer Research FBXW7 Breast cancer ncRNAs regulation Angiogenesis Immune escape Drug resistance |
| title | FBXW7 in breast cancer: mechanism of action and therapeutic potential |
| title_full | FBXW7 in breast cancer: mechanism of action and therapeutic potential |
| title_fullStr | FBXW7 in breast cancer: mechanism of action and therapeutic potential |
| title_full_unstemmed | FBXW7 in breast cancer: mechanism of action and therapeutic potential |
| title_short | FBXW7 in breast cancer: mechanism of action and therapeutic potential |
| title_sort | fbxw7 in breast cancer mechanism of action and therapeutic potential |
| topic | FBXW7 Breast cancer ncRNAs regulation Angiogenesis Immune escape Drug resistance |
| url | https://doi.org/10.1186/s13046-023-02767-1 |
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