CAR T-Cells Depend on the Coupling of NADH Oxidation with ATP Production

CAR T-Cells Depend on the Coupling of NADH Oxidation with ATP Production

The metabolic milieu of solid tumors provides a barrier to chimeric antigen receptor (CAR) T-cell therapies. Excessive lactate or hypoxia suppresses T-cell growth, through mechanisms including NADH buildup and the depletion of oxidized metabolites. NADH is converted into NAD<sup>+</sup>...

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Bibliographic Details
Main Authors: Juan C. Garcia-Canaveras, David Heo, Sophie Trefely, John Leferovich, Chong Xu, Benjamin I. Philipson, Saba Ghassemi, Michael C. Milone, Edmund K. Moon, Nathaniel W. Snyder, Carl H. June, Joshua D. Rabinowitz, Roddy S. O’Connor
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
armor CAR T-cells
<i>Lactobacillus brevis</i> NADH oxidase
LDHA
Online Access:https://www.mdpi.com/2073-4409/10/9/2334

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