| Summary: | In the last years <em>Acinetobacter baumannii</em> has become one of the germs of higher clinical relevance, which really turns it into a paradigm in the nosocomial multi-drug resistant infections. The present work had the objective of describing the resistance mechanisms of <em>Acinetobacter baumannii</em> to multiple drugs, so as to explain current therapeutic strategies in multidrug-resistant strains; for that 37 bibliographic resources were consulted. The mechanisms involved in the micro-organism resistance include inhibition to the antibiotic by β-lactamases, decreasing of antibiotic permeability due to porin loses, presence of efflux pumps and drug action site disturbances. It is recommended that the treatment of choice in multi-drug resistant strains is colistin and tigecycline, though other drugs may be used so as their combination.
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