Multidrug-resistant Acinetobacter baumannii: a challange for current therapeutic
In the last years <em>Acinetobacter baumannii</em> has become one of the germs of higher clinical relevance, which really turns it into a paradigm in the nosocomial multi-drug resistant infections. The present work had the objective of describing the resistance mechanisms of <em>Ac...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Spanish |
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Centro Provincial de Información de Ciencias Médicas. Cienfuegos
2018-04-01
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| Series: | Medisur |
| Subjects: | |
| Online Access: | http://medisur.sld.cu/index.php/medisur/article/view/3783 |
| _version_ | 1797277840975069184 |
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| author | Roberto Carlos Barletta Farías Leonardo Javier Pérez Ponce Gabriela Castro Vega Misael Pujol Pérez Jorge Emilio Barletta del Castillo Yeny Dueñas Pérez |
| author_facet | Roberto Carlos Barletta Farías Leonardo Javier Pérez Ponce Gabriela Castro Vega Misael Pujol Pérez Jorge Emilio Barletta del Castillo Yeny Dueñas Pérez |
| author_sort | Roberto Carlos Barletta Farías |
| collection | DOAJ |
| description | In the last years <em>Acinetobacter baumannii</em> has become one of the germs of higher clinical relevance, which really turns it into a paradigm in the nosocomial multi-drug resistant infections. The present work had the objective of describing the resistance mechanisms of <em>Acinetobacter baumannii</em> to multiple drugs, so as to explain current therapeutic strategies in multidrug-resistant strains; for that 37 bibliographic resources were consulted. The mechanisms involved in the micro-organism resistance include inhibition to the antibiotic by β-lactamases, decreasing of antibiotic permeability due to porin loses, presence of efflux pumps and drug action site disturbances. It is recommended that the treatment of choice in multi-drug resistant strains is colistin and tigecycline, though other drugs may be used so as their combination. |
| first_indexed | 2024-03-07T15:55:08Z |
| format | Article |
| id | doaj.art-50d66dd5197b47adb88bd58698a83e60 |
| institution | Directory Open Access Journal |
| issn | 1727-897X |
| language | Spanish |
| last_indexed | 2024-03-07T15:55:08Z |
| publishDate | 2018-04-01 |
| publisher | Centro Provincial de Información de Ciencias Médicas. Cienfuegos |
| record_format | Article |
| series | Medisur |
| spelling | doaj.art-50d66dd5197b47adb88bd58698a83e602024-03-04T23:09:47ZspaCentro Provincial de Información de Ciencias Médicas. CienfuegosMedisur1727-897X2018-04-011623223341545Multidrug-resistant Acinetobacter baumannii: a challange for current therapeuticRoberto Carlos Barletta Farías0Leonardo Javier Pérez Ponce1Gabriela Castro Vega2Misael Pujol Pérez3Jorge Emilio Barletta del Castillo4Yeny Dueñas Pérez5Universidad de Ciencias Médicas de CienfuegosUniversidad de Ciencias Médicas de CienfuegosUniversidad de Ciencias Médicas de CienfuegosUniversidad de Ciencias Médicas de CienfuegosHospital General Universitario Dr. Gustavo Aldereguía Lima. CienfuegosUniversidad de Ciencias Médicas de CienfuegosIn the last years <em>Acinetobacter baumannii</em> has become one of the germs of higher clinical relevance, which really turns it into a paradigm in the nosocomial multi-drug resistant infections. The present work had the objective of describing the resistance mechanisms of <em>Acinetobacter baumannii</em> to multiple drugs, so as to explain current therapeutic strategies in multidrug-resistant strains; for that 37 bibliographic resources were consulted. The mechanisms involved in the micro-organism resistance include inhibition to the antibiotic by β-lactamases, decreasing of antibiotic permeability due to porin loses, presence of efflux pumps and drug action site disturbances. It is recommended that the treatment of choice in multi-drug resistant strains is colistin and tigecycline, though other drugs may be used so as their combination.http://medisur.sld.cu/index.php/medisur/article/view/3783acinetobacter baumanniifarmacorresistencia microbianatratamiento farmacológico |
| spellingShingle | Roberto Carlos Barletta Farías Leonardo Javier Pérez Ponce Gabriela Castro Vega Misael Pujol Pérez Jorge Emilio Barletta del Castillo Yeny Dueñas Pérez Multidrug-resistant Acinetobacter baumannii: a challange for current therapeutic Medisur acinetobacter baumannii farmacorresistencia microbiana tratamiento farmacológico |
| title | Multidrug-resistant Acinetobacter baumannii: a challange for current therapeutic |
| title_full | Multidrug-resistant Acinetobacter baumannii: a challange for current therapeutic |
| title_fullStr | Multidrug-resistant Acinetobacter baumannii: a challange for current therapeutic |
| title_full_unstemmed | Multidrug-resistant Acinetobacter baumannii: a challange for current therapeutic |
| title_short | Multidrug-resistant Acinetobacter baumannii: a challange for current therapeutic |
| title_sort | multidrug resistant acinetobacter baumannii a challange for current therapeutic |
| topic | acinetobacter baumannii farmacorresistencia microbiana tratamiento farmacológico |
| url | http://medisur.sld.cu/index.php/medisur/article/view/3783 |
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