3D Printed Paper-Based Microfluidic Analytical Devices
As a pump-free and lightweight analytical tool, paper-based microfluidic analytical devices (μPADs) attract more and more interest. If the flow speed of μPAD can be programmed, the analytical sequences could be designed and they will be more popular. This reports presents a novel μPAD, driven by the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-06-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-666X/7/7/108 |
| _version_ | 1818237769495871488 |
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| author | Yong He Qing Gao Wen-Bin Wu Jing Nie Jian-Zhong Fu |
| author_facet | Yong He Qing Gao Wen-Bin Wu Jing Nie Jian-Zhong Fu |
| author_sort | Yong He |
| collection | DOAJ |
| description | As a pump-free and lightweight analytical tool, paper-based microfluidic analytical devices (μPADs) attract more and more interest. If the flow speed of μPAD can be programmed, the analytical sequences could be designed and they will be more popular. This reports presents a novel μPAD, driven by the capillary force of cellulose powder, printed by a desktop three-dimensional (3D) printer, which has some promising features, such as easy fabrication and programmable flow speed. First, a suitable size-scale substrate with open microchannels on its surface is printed. Next, the surface of the substrate is covered with a thin layer of polydimethylsiloxane (PDMS) to seal the micro gap caused by 3D printing. Then, the microchannels are filled with a mixture of cellulose powder and deionized water in an appropriate proportion. After drying in an oven at 60 °C for 30 min, it is ready for use. As the different channel depths can be easily printed, which can be used to achieve the programmable capillary flow speed of cellulose powder in the microchannels. A series of microfluidic analytical experiments, including quantitative analysis of nitrite ion and fabrication of T-sensor were used to demonstrate its capability. As the desktop 3D printer (D3DP) is very cheap and accessible, this device can be rapidly printed at the test field with a low cost and has a promising potential in the point-of-care (POC) system or as a lightweight platform for analytical chemistry. |
| first_indexed | 2024-12-12T12:31:01Z |
| format | Article |
| id | doaj.art-50d6e33dcb2249029b5f62c7200d7096 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-12-12T12:31:01Z |
| publishDate | 2016-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-50d6e33dcb2249029b5f62c7200d70962022-12-22T00:24:25ZengMDPI AGMicromachines2072-666X2016-06-017710810.3390/mi7070108mi70701083D Printed Paper-Based Microfluidic Analytical DevicesYong He0Qing Gao1Wen-Bin Wu2Jing Nie3Jian-Zhong Fu4State Key Laboratory of Fluid Power and Mechatronic Systems, College of Mechanical Engineering, Zhejiang University, Hangzhou 310027, ChinaState Key Laboratory of Fluid Power and Mechatronic Systems, College of Mechanical Engineering, Zhejiang University, Hangzhou 310027, ChinaState Key Laboratory of Fluid Power and Mechatronic Systems, College of Mechanical Engineering, Zhejiang University, Hangzhou 310027, ChinaState Key Laboratory of Fluid Power and Mechatronic Systems, College of Mechanical Engineering, Zhejiang University, Hangzhou 310027, ChinaState Key Laboratory of Fluid Power and Mechatronic Systems, College of Mechanical Engineering, Zhejiang University, Hangzhou 310027, ChinaAs a pump-free and lightweight analytical tool, paper-based microfluidic analytical devices (μPADs) attract more and more interest. If the flow speed of μPAD can be programmed, the analytical sequences could be designed and they will be more popular. This reports presents a novel μPAD, driven by the capillary force of cellulose powder, printed by a desktop three-dimensional (3D) printer, which has some promising features, such as easy fabrication and programmable flow speed. First, a suitable size-scale substrate with open microchannels on its surface is printed. Next, the surface of the substrate is covered with a thin layer of polydimethylsiloxane (PDMS) to seal the micro gap caused by 3D printing. Then, the microchannels are filled with a mixture of cellulose powder and deionized water in an appropriate proportion. After drying in an oven at 60 °C for 30 min, it is ready for use. As the different channel depths can be easily printed, which can be used to achieve the programmable capillary flow speed of cellulose powder in the microchannels. A series of microfluidic analytical experiments, including quantitative analysis of nitrite ion and fabrication of T-sensor were used to demonstrate its capability. As the desktop 3D printer (D3DP) is very cheap and accessible, this device can be rapidly printed at the test field with a low cost and has a promising potential in the point-of-care (POC) system or as a lightweight platform for analytical chemistry.http://www.mdpi.com/2072-666X/7/7/1083D printingpaper-based microfluidic analytical devices (μPADs)flow speed programming |
| spellingShingle | Yong He Qing Gao Wen-Bin Wu Jing Nie Jian-Zhong Fu 3D Printed Paper-Based Microfluidic Analytical Devices Micromachines 3D printing paper-based microfluidic analytical devices (μPADs) flow speed programming |
| title | 3D Printed Paper-Based Microfluidic Analytical Devices |
| title_full | 3D Printed Paper-Based Microfluidic Analytical Devices |
| title_fullStr | 3D Printed Paper-Based Microfluidic Analytical Devices |
| title_full_unstemmed | 3D Printed Paper-Based Microfluidic Analytical Devices |
| title_short | 3D Printed Paper-Based Microfluidic Analytical Devices |
| title_sort | 3d printed paper based microfluidic analytical devices |
| topic | 3D printing paper-based microfluidic analytical devices (μPADs) flow speed programming |
| url | http://www.mdpi.com/2072-666X/7/7/108 |
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