Discovery of dibenzyl amide derivatives as novel CXCR4 modulators against inflammatory bowel disease

Discovery of dibenzyl amide derivatives as novel CXCR4 modulators against inflammatory bowel disease

The CXCR4/CXCL12 chemokine axis demonstrates significant potential in the treatment of inflammatory bowel disease (IBD) due to its crucial roles in inflammatory and immune responses. Modulating the CXCR4/CXCL12 pathway can be an effective therapeutic approach to ameliorate the inflammatory state of...

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Bibliographic Details
Main Authors:	Xiaoying Jiang, Liuxin Lu, Jiahui Wang, Meng Yu, Rui Wu, Rui Zhao, Hao Wen, Renren Bai
Format:	Article
Language:	English
Published:	Elsevier 2024-04-01
Series:	European Journal of Medicinal Chemistry Reports
Subjects:	CXCR4 modulators Dibenzyl amide derivatives Inflammatory bowel disease (IBD) Anti-inflammatory activity
Online Access:	http://www.sciencedirect.com/science/article/pii/S2772417424000062

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