Tumor size, but not consolidation‐to‐tumor ratio, is an independent prognostic factor for part‐solid clinical T1 non‐small cell lung cancer
Abstract Background Tumor size and consolidation‐to‐tumor ratio (CTR) are crucial for non–small cell lung cancer (NSCLC) prognosis. However, the optimal CTR cutoff remains unclear. Whether tumor size and CTR are independent prognostic factors for part‐solid NSCLC is under debate. Here, we aimed to e...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-02-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.14788 |
| _version_ | 1797894391344398336 |
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| author | Zhihua Li Wenzheng Xu Tianhao Gu Xincen Cao Weibing Wu Liang Chen |
| author_facet | Zhihua Li Wenzheng Xu Tianhao Gu Xincen Cao Weibing Wu Liang Chen |
| author_sort | Zhihua Li |
| collection | DOAJ |
| description | Abstract Background Tumor size and consolidation‐to‐tumor ratio (CTR) are crucial for non–small cell lung cancer (NSCLC) prognosis. However, the optimal CTR cutoff remains unclear. Whether tumor size and CTR are independent prognostic factors for part‐solid NSCLC is under debate. Here, we aimed to evaluate the prognostic impacts of CTR and tumor size on NSCLC, especially on part‐solid NSCLC. Methods We reviewed 1366 clinical T1 NSCLC patients who underwent surgical treatment. Log‐rank test and Cox regression analyses were adopted for prognostic evaluation. The “surv_cutpoint” function was used to identify the optimal CTR and tumor size cutoff values. Results There were 416, 510, and 440 subjects with pure ground‐glass opacity (pGGO), part‐solid, and pure solid nodules. The 5‐year overall survival (disease‐free survival) for patients with pGGO, part‐solid, and pure solid nodules were 99.5% (99.5%), 97.3% (95.8%), and 90.4% (78.9%), respectively. Multivariate Cox regression analysis indicated that CTR was an independent prognostic factor for the whole patients, and the optimal CTR cutoff was 0.99. However, for part‐solid NSCLC, CTR was not independently associated with survival, even if categorized by the optimal cutoffs. The predicted optimal cutoffs of total tumor size and solid component size were 2.4 and 1.4 cm for part‐solid NSCLC. Total tumor size (HR = 6.21, 95% CI: 1.58–24.34, p = 0.009) and solid component size (HR = 2.27, 95% CI: 1.04–5.92, p = 0.045) grouped by the cutoffs were significantly associated with part‐solid NSCLC prognosis. Conclusions CTR was an independent prognostic factor for the whole NSCLC, but not for the part‐solid NSCLC. Tumor size was still meaningful for part‐solid NSCLC. |
| first_indexed | 2024-04-10T07:08:17Z |
| format | Article |
| id | doaj.art-50d846e01f9543248f2cf65ebbfe626c |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-10T07:08:17Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-50d846e01f9543248f2cf65ebbfe626c2023-02-27T01:36:59ZengWileyThoracic Cancer1759-77061759-77142023-02-0114660261110.1111/1759-7714.14788Tumor size, but not consolidation‐to‐tumor ratio, is an independent prognostic factor for part‐solid clinical T1 non‐small cell lung cancerZhihua Li0Wenzheng Xu1Tianhao Gu2Xincen Cao3Weibing Wu4Liang Chen5Department of Thoracic Surgery Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Thoracic Surgery Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Thoracic Surgery Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Thoracic Surgery Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Thoracic Surgery Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Thoracic Surgery Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaAbstract Background Tumor size and consolidation‐to‐tumor ratio (CTR) are crucial for non–small cell lung cancer (NSCLC) prognosis. However, the optimal CTR cutoff remains unclear. Whether tumor size and CTR are independent prognostic factors for part‐solid NSCLC is under debate. Here, we aimed to evaluate the prognostic impacts of CTR and tumor size on NSCLC, especially on part‐solid NSCLC. Methods We reviewed 1366 clinical T1 NSCLC patients who underwent surgical treatment. Log‐rank test and Cox regression analyses were adopted for prognostic evaluation. The “surv_cutpoint” function was used to identify the optimal CTR and tumor size cutoff values. Results There were 416, 510, and 440 subjects with pure ground‐glass opacity (pGGO), part‐solid, and pure solid nodules. The 5‐year overall survival (disease‐free survival) for patients with pGGO, part‐solid, and pure solid nodules were 99.5% (99.5%), 97.3% (95.8%), and 90.4% (78.9%), respectively. Multivariate Cox regression analysis indicated that CTR was an independent prognostic factor for the whole patients, and the optimal CTR cutoff was 0.99. However, for part‐solid NSCLC, CTR was not independently associated with survival, even if categorized by the optimal cutoffs. The predicted optimal cutoffs of total tumor size and solid component size were 2.4 and 1.4 cm for part‐solid NSCLC. Total tumor size (HR = 6.21, 95% CI: 1.58–24.34, p = 0.009) and solid component size (HR = 2.27, 95% CI: 1.04–5.92, p = 0.045) grouped by the cutoffs were significantly associated with part‐solid NSCLC prognosis. Conclusions CTR was an independent prognostic factor for the whole NSCLC, but not for the part‐solid NSCLC. Tumor size was still meaningful for part‐solid NSCLC.https://doi.org/10.1111/1759-7714.14788consolidation‐to‐tumor ratioground‐glass opacitynon‐small cell lung cancerpart‐solid nodulestumor size |
| spellingShingle | Zhihua Li Wenzheng Xu Tianhao Gu Xincen Cao Weibing Wu Liang Chen Tumor size, but not consolidation‐to‐tumor ratio, is an independent prognostic factor for part‐solid clinical T1 non‐small cell lung cancer Thoracic Cancer consolidation‐to‐tumor ratio ground‐glass opacity non‐small cell lung cancer part‐solid nodules tumor size |
| title | Tumor size, but not consolidation‐to‐tumor ratio, is an independent prognostic factor for part‐solid clinical T1 non‐small cell lung cancer |
| title_full | Tumor size, but not consolidation‐to‐tumor ratio, is an independent prognostic factor for part‐solid clinical T1 non‐small cell lung cancer |
| title_fullStr | Tumor size, but not consolidation‐to‐tumor ratio, is an independent prognostic factor for part‐solid clinical T1 non‐small cell lung cancer |
| title_full_unstemmed | Tumor size, but not consolidation‐to‐tumor ratio, is an independent prognostic factor for part‐solid clinical T1 non‐small cell lung cancer |
| title_short | Tumor size, but not consolidation‐to‐tumor ratio, is an independent prognostic factor for part‐solid clinical T1 non‐small cell lung cancer |
| title_sort | tumor size but not consolidation to tumor ratio is an independent prognostic factor for part solid clinical t1 non small cell lung cancer |
| topic | consolidation‐to‐tumor ratio ground‐glass opacity non‐small cell lung cancer part‐solid nodules tumor size |
| url | https://doi.org/10.1111/1759-7714.14788 |
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