Prion protein gene frequencies in three Sicilian dairy sheep populations
The objective of this paper was to investigate the prion protein (PrP) genotype and haplotype frequencies in three Sicilian dairy sheep populations. The three populations were: (1) 1096 Valle del Belice animals, (2) 1143 Comisana animals, and (3) 1771 individuals from 5 flocks with scrapie outbreaks...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2010-01-01
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| Series: | Italian Journal of Animal Science |
| Subjects: | |
| Online Access: | http://www.aspajournal.it/index.php/ijas/article/view/44 |
| _version_ | 1818485124622188544 |
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| author | Santo Caracappa Pascal A. Oltenacu Baldassarre Portolano Marina Scimonelli Fabrizio Vitale Francesco Pinelli Johannes B.C.H.M. van Kaam Maria Vitale Raffaella Finocchiaro |
| author_facet | Santo Caracappa Pascal A. Oltenacu Baldassarre Portolano Marina Scimonelli Fabrizio Vitale Francesco Pinelli Johannes B.C.H.M. van Kaam Maria Vitale Raffaella Finocchiaro |
| author_sort | Santo Caracappa |
| collection | DOAJ |
| description | The objective of this paper was to investigate the prion protein (PrP) genotype and haplotype frequencies in three Sicilian dairy sheep populations. The three populations were: (1) 1096 Valle del Belice animals, (2) 1143 Comisana animals, and (3) 1771 individuals from 5 flocks with scrapie outbreaks, in which the animals were crossbreds derived from indigenous Sicilian dairy breeds. PrP genotypes are described for the three codons 136 (Alanine or Valine; A, V), 154 (Histidine or Arginine; H, R), and 171 (Glutamine, Arginine or Histidine; Q, R, H) which represent polymorphisms known to be linked with scrapie susceptibility. The Valle del Belice haplotype frequencies were 32.3% ARR, 6.5% AHQ, 1.0% ARH, 58.8% ARQ, and 1.4% VRQ. The Comisana frequencies were 39.4% ARR, 2.9% AHQ, 2.9% ARH, 50.9% ARQ, and 3.9% VRQ. In the flocks with scrapie outbreaks the frequencies were 32.8% ARR, 2.4% AHQ, 1.7% ARH, 59.1% ARQ, and 3.9% VRQ. In all three populations ARQ and ARR were the most frequent haplotypes. Multiple generations of strong selection will be needed to fixate the most resistant ARR haplotype. |
| first_indexed | 2024-12-10T16:04:19Z |
| format | Article |
| id | doaj.art-50d97f3a78bc40d4a642944cd0f50dbd |
| institution | Directory Open Access Journal |
| issn | 1594-4077 1828-051X |
| language | English |
| last_indexed | 2024-12-10T16:04:19Z |
| publishDate | 2010-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Italian Journal of Animal Science |
| spelling | doaj.art-50d97f3a78bc40d4a642944cd0f50dbd2022-12-22T01:42:19ZengTaylor & Francis GroupItalian Journal of Animal Science1594-40771828-051X2010-01-0171879410.4081/ijas.2008.87Prion protein gene frequencies in three Sicilian dairy sheep populationsSanto CaracappaPascal A. OltenacuBaldassarre PortolanoMarina ScimonelliFabrizio VitaleFrancesco PinelliJohannes B.C.H.M. van KaamMaria VitaleRaffaella FinocchiaroThe objective of this paper was to investigate the prion protein (PrP) genotype and haplotype frequencies in three Sicilian dairy sheep populations. The three populations were: (1) 1096 Valle del Belice animals, (2) 1143 Comisana animals, and (3) 1771 individuals from 5 flocks with scrapie outbreaks, in which the animals were crossbreds derived from indigenous Sicilian dairy breeds. PrP genotypes are described for the three codons 136 (Alanine or Valine; A, V), 154 (Histidine or Arginine; H, R), and 171 (Glutamine, Arginine or Histidine; Q, R, H) which represent polymorphisms known to be linked with scrapie susceptibility. The Valle del Belice haplotype frequencies were 32.3% ARR, 6.5% AHQ, 1.0% ARH, 58.8% ARQ, and 1.4% VRQ. The Comisana frequencies were 39.4% ARR, 2.9% AHQ, 2.9% ARH, 50.9% ARQ, and 3.9% VRQ. In the flocks with scrapie outbreaks the frequencies were 32.8% ARR, 2.4% AHQ, 1.7% ARH, 59.1% ARQ, and 3.9% VRQ. In all three populations ARQ and ARR were the most frequent haplotypes. Multiple generations of strong selection will be needed to fixate the most resistant ARR haplotype.http://www.aspajournal.it/index.php/ijas/article/view/44Haplotype frequency, Prion protein, Scrapie, Sheep. |
| spellingShingle | Santo Caracappa Pascal A. Oltenacu Baldassarre Portolano Marina Scimonelli Fabrizio Vitale Francesco Pinelli Johannes B.C.H.M. van Kaam Maria Vitale Raffaella Finocchiaro Prion protein gene frequencies in three Sicilian dairy sheep populations Italian Journal of Animal Science Haplotype frequency, Prion protein, Scrapie, Sheep. |
| title | Prion protein gene frequencies in three Sicilian dairy sheep populations |
| title_full | Prion protein gene frequencies in three Sicilian dairy sheep populations |
| title_fullStr | Prion protein gene frequencies in three Sicilian dairy sheep populations |
| title_full_unstemmed | Prion protein gene frequencies in three Sicilian dairy sheep populations |
| title_short | Prion protein gene frequencies in three Sicilian dairy sheep populations |
| title_sort | prion protein gene frequencies in three sicilian dairy sheep populations |
| topic | Haplotype frequency, Prion protein, Scrapie, Sheep. |
| url | http://www.aspajournal.it/index.php/ijas/article/view/44 |
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