Distinct patterns of fasting plasma glucose and lipid profile levels over time in adults tested positive for HIV on HAART in Shanghai, China, revealed using growth mixture models
ObjectivesThis study sought to identify potential change patterns and predictors of fasting plasma glucose (FPG) and lipid levels after initiating highly active antiretroviral therapy (HAART).MethodsA retrospective cohort study was conducted on 1,572 patients tested positive for HIV who initiated HA...
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1071431/full |
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| author | Jingjing Lang Xin Xin Xin Xin Panpan Chen Panpan Chen Zhen Ning Shaotan Xiao Shaotan Xiao |
| author_facet | Jingjing Lang Xin Xin Xin Xin Panpan Chen Panpan Chen Zhen Ning Shaotan Xiao Shaotan Xiao |
| author_sort | Jingjing Lang |
| collection | DOAJ |
| description | ObjectivesThis study sought to identify potential change patterns and predictors of fasting plasma glucose (FPG) and lipid levels after initiating highly active antiretroviral therapy (HAART).MethodsA retrospective cohort study was conducted on 1,572 patients tested positive for HIV who initiated HAART between January 2010 and October 2020 in Shanghai, China. The growth mixture models (GMM) were used for capturing subgroups of FPG trajectories as well as triglyceride (TG) and total cholesterol (TC) dual-trajectories. Multinomial logistic regression models identified correlates of given trajectories.ResultsThe median follow-up time was 2.0 years (IQR 1.0–4.7). Three FPG trajectory subgroups were identified as FPG low-stable (62.3%), medium-stable (30.5%), and high-increasing (7.2%). Furthermore, three subgroups of TG and TC dual-trajectories were identified as TG and TC high-slight increasing (13.7%), low-rapid increasing (27.6%), and a subgroup of medium-stable TC and slight-decreasing TG (58.7%). Older age, high TG, FPG, BMI, CD4 count of <200 at baseline, and initial use of zidovudine (AZT) and protease inhibitors (PIs) helped to identify the class with increasing glucose or lipid metabolism trajectories.ConclusionThe change patterns of plasma glucose and lipid in patients tested positive for HIV were heterogeneous and tailored interventions should be considered in specific subgroups. |
| first_indexed | 2024-04-10T05:27:50Z |
| format | Article |
| id | doaj.art-50d9e87537184b5090029b212a8a3a9c |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-10T05:27:50Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj.art-50d9e87537184b5090029b212a8a3a9c2023-03-07T12:09:55ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-01-01910.3389/fmed.2022.10714311071431Distinct patterns of fasting plasma glucose and lipid profile levels over time in adults tested positive for HIV on HAART in Shanghai, China, revealed using growth mixture modelsJingjing Lang0Xin Xin1Xin Xin2Panpan Chen3Panpan Chen4Zhen Ning5Shaotan Xiao6Shaotan Xiao7School of Public Health, Fudan University, Shanghai, ChinaPudong New Area Center for Disease Control and Prevention, Shanghai, ChinaPudong Institute of Preventive Medicine, Fudan University, Shanghai, ChinaPudong New Area Center for Disease Control and Prevention, Shanghai, ChinaPudong Institute of Preventive Medicine, Fudan University, Shanghai, ChinaShanghai Center for Disease Control and Prevention, Shanghai, ChinaPudong New Area Center for Disease Control and Prevention, Shanghai, ChinaPudong Institute of Preventive Medicine, Fudan University, Shanghai, ChinaObjectivesThis study sought to identify potential change patterns and predictors of fasting plasma glucose (FPG) and lipid levels after initiating highly active antiretroviral therapy (HAART).MethodsA retrospective cohort study was conducted on 1,572 patients tested positive for HIV who initiated HAART between January 2010 and October 2020 in Shanghai, China. The growth mixture models (GMM) were used for capturing subgroups of FPG trajectories as well as triglyceride (TG) and total cholesterol (TC) dual-trajectories. Multinomial logistic regression models identified correlates of given trajectories.ResultsThe median follow-up time was 2.0 years (IQR 1.0–4.7). Three FPG trajectory subgroups were identified as FPG low-stable (62.3%), medium-stable (30.5%), and high-increasing (7.2%). Furthermore, three subgroups of TG and TC dual-trajectories were identified as TG and TC high-slight increasing (13.7%), low-rapid increasing (27.6%), and a subgroup of medium-stable TC and slight-decreasing TG (58.7%). Older age, high TG, FPG, BMI, CD4 count of <200 at baseline, and initial use of zidovudine (AZT) and protease inhibitors (PIs) helped to identify the class with increasing glucose or lipid metabolism trajectories.ConclusionThe change patterns of plasma glucose and lipid in patients tested positive for HIV were heterogeneous and tailored interventions should be considered in specific subgroups.https://www.frontiersin.org/articles/10.3389/fmed.2022.1071431/fullHIVHAARTgrowth mixture modelfasting plasma glucoselipid |
| spellingShingle | Jingjing Lang Xin Xin Xin Xin Panpan Chen Panpan Chen Zhen Ning Shaotan Xiao Shaotan Xiao Distinct patterns of fasting plasma glucose and lipid profile levels over time in adults tested positive for HIV on HAART in Shanghai, China, revealed using growth mixture models Frontiers in Medicine HIV HAART growth mixture model fasting plasma glucose lipid |
| title | Distinct patterns of fasting plasma glucose and lipid profile levels over time in adults tested positive for HIV on HAART in Shanghai, China, revealed using growth mixture models |
| title_full | Distinct patterns of fasting plasma glucose and lipid profile levels over time in adults tested positive for HIV on HAART in Shanghai, China, revealed using growth mixture models |
| title_fullStr | Distinct patterns of fasting plasma glucose and lipid profile levels over time in adults tested positive for HIV on HAART in Shanghai, China, revealed using growth mixture models |
| title_full_unstemmed | Distinct patterns of fasting plasma glucose and lipid profile levels over time in adults tested positive for HIV on HAART in Shanghai, China, revealed using growth mixture models |
| title_short | Distinct patterns of fasting plasma glucose and lipid profile levels over time in adults tested positive for HIV on HAART in Shanghai, China, revealed using growth mixture models |
| title_sort | distinct patterns of fasting plasma glucose and lipid profile levels over time in adults tested positive for hiv on haart in shanghai china revealed using growth mixture models |
| topic | HIV HAART growth mixture model fasting plasma glucose lipid |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1071431/full |
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