An unusual case of lymphoma — a case of extranodal NK/T-cell lymphoma, nasal type
Abstract Background There is a great geographic variation of extranodal natural killer (NK)/T-cell lymphoma, nasal type (NNKTL) prevalence, with a much higher prevalence in the Asian and South American populations. According to our knowledge and searches, only one other case report/study of NNKTL ha...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-09-01
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| Series: | The Egyptian Journal of Otolaryngology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43163-022-00299-7 |
| _version_ | 1827280031421825024 |
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| author | Mahlatse Mankgele Lindokuhle Goqwana Vinitha Philip Faadil Waja Atul Lakha Yvonne Perner Moosa Patel |
| author_facet | Mahlatse Mankgele Lindokuhle Goqwana Vinitha Philip Faadil Waja Atul Lakha Yvonne Perner Moosa Patel |
| author_sort | Mahlatse Mankgele |
| collection | DOAJ |
| description | Abstract Background There is a great geographic variation of extranodal natural killer (NK)/T-cell lymphoma, nasal type (NNKTL) prevalence, with a much higher prevalence in the Asian and South American populations. According to our knowledge and searches, only one other case report/study of NNKTL has been published in South Africa. Case presentation We present a southern-African 31-year-old male residing in a township in the south of Johannesburg, South Africa. He presented with signs and symptoms similar to those of benign upper airway diseases. Further work-up of persisting signs and symptoms yielded a diagnosis of NNKTL. He was treated with the SMILE (steroids — dexamethasone, methotrexate, ifosfamide, L-asparaginase and etoposide) chemotherapy regimen, and sandwich radiotherapy was planned. He had a partial response to chemotherapy but unfortunately demised due to overwhelming sepsis prior to radiation therapy. Conclusion Making a diagnosis of NNKTL in resource-limited settings is challenging as the diagnosis requires not only the demonstration of NK-cell markers but also to have a positive Epstein-Barr virus (EBV) in situ hybridization (EBER-ISH). Collaboration of smaller centres with larger and better equipped centres is required to diagnose and document NNKTL more accurately in the African setting. |
| first_indexed | 2024-04-11T20:07:58Z |
| format | Article |
| id | doaj.art-50db9566f14b47f7abdf88584ab529b9 |
| institution | Directory Open Access Journal |
| issn | 1012-5574 2090-8539 |
| language | English |
| last_indexed | 2024-04-24T08:30:00Z |
| publishDate | 2022-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Otolaryngology |
| spelling | doaj.art-50db9566f14b47f7abdf88584ab529b92024-04-16T19:57:11ZengSpringerOpenThe Egyptian Journal of Otolaryngology1012-55742090-85392022-09-013811610.1186/s43163-022-00299-7An unusual case of lymphoma — a case of extranodal NK/T-cell lymphoma, nasal typeMahlatse Mankgele0Lindokuhle Goqwana1Vinitha Philip2Faadil Waja3Atul Lakha4Yvonne Perner5Moosa Patel6Division of Internal Medicine, Faculty of Health Sciences, School of Clinical Medicine, University of the WitwatersrandDivision of Internal Medicine, Faculty of Health Sciences, School of Clinical Medicine, University of the WitwatersrandDivision of Internal Medicine, Faculty of Health Sciences, School of Clinical Medicine, University of the WitwatersrandDivision of Internal Medicine, Faculty of Health Sciences, School of Clinical Medicine, University of the WitwatersrandDivision of Internal Medicine, Faculty of Health Sciences, School of Clinical Medicine, University of the WitwatersrandDivision of Anatomical Pathology, Faculty of Health Sciences, School of Pathology, University of the WitwatersrandDivision of Internal Medicine, Faculty of Health Sciences, School of Clinical Medicine, University of the WitwatersrandAbstract Background There is a great geographic variation of extranodal natural killer (NK)/T-cell lymphoma, nasal type (NNKTL) prevalence, with a much higher prevalence in the Asian and South American populations. According to our knowledge and searches, only one other case report/study of NNKTL has been published in South Africa. Case presentation We present a southern-African 31-year-old male residing in a township in the south of Johannesburg, South Africa. He presented with signs and symptoms similar to those of benign upper airway diseases. Further work-up of persisting signs and symptoms yielded a diagnosis of NNKTL. He was treated with the SMILE (steroids — dexamethasone, methotrexate, ifosfamide, L-asparaginase and etoposide) chemotherapy regimen, and sandwich radiotherapy was planned. He had a partial response to chemotherapy but unfortunately demised due to overwhelming sepsis prior to radiation therapy. Conclusion Making a diagnosis of NNKTL in resource-limited settings is challenging as the diagnosis requires not only the demonstration of NK-cell markers but also to have a positive Epstein-Barr virus (EBV) in situ hybridization (EBER-ISH). Collaboration of smaller centres with larger and better equipped centres is required to diagnose and document NNKTL more accurately in the African setting.https://doi.org/10.1186/s43163-022-00299-7Epstein-Barr virus (EBV)Natural killer (NK) cellsLymphomaExtranodal NK/T-cell lymphomaNasal type (NNKTL)Diagnosis |
| spellingShingle | Mahlatse Mankgele Lindokuhle Goqwana Vinitha Philip Faadil Waja Atul Lakha Yvonne Perner Moosa Patel An unusual case of lymphoma — a case of extranodal NK/T-cell lymphoma, nasal type The Egyptian Journal of Otolaryngology Epstein-Barr virus (EBV) Natural killer (NK) cells Lymphoma Extranodal NK/T-cell lymphoma Nasal type (NNKTL) Diagnosis |
| title | An unusual case of lymphoma — a case of extranodal NK/T-cell lymphoma, nasal type |
| title_full | An unusual case of lymphoma — a case of extranodal NK/T-cell lymphoma, nasal type |
| title_fullStr | An unusual case of lymphoma — a case of extranodal NK/T-cell lymphoma, nasal type |
| title_full_unstemmed | An unusual case of lymphoma — a case of extranodal NK/T-cell lymphoma, nasal type |
| title_short | An unusual case of lymphoma — a case of extranodal NK/T-cell lymphoma, nasal type |
| title_sort | unusual case of lymphoma a case of extranodal nk t cell lymphoma nasal type |
| topic | Epstein-Barr virus (EBV) Natural killer (NK) cells Lymphoma Extranodal NK/T-cell lymphoma Nasal type (NNKTL) Diagnosis |
| url | https://doi.org/10.1186/s43163-022-00299-7 |
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