Neuroprotective Activity of Lavender Oil on Transient Focal Cerebral Ischemia in Mice
The air-<em>dried aerial parts</em> of<em> Lavandula angustifolia</em> Mill, a traditional Uygur herbal drug, is used as resuscitation-inducing therapy to treat neurodisfunctions, such as stroke. This study was designed to assess the neuroprote...
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MDPI AG
2012-08-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/17/8/9803 |
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| author | Qiusheng Zheng Zhenhua Wang Yanli Hu Liangliang Liu Dong Wang Xuan Yuan Ting Liu |
| author_facet | Qiusheng Zheng Zhenhua Wang Yanli Hu Liangliang Liu Dong Wang Xuan Yuan Ting Liu |
| author_sort | Qiusheng Zheng |
| collection | DOAJ |
| description | The air-<em>dried aerial parts</em> of<em> Lavandula angustifolia</em> Mill, a traditional Uygur herbal drug, is used as resuscitation-inducing therapy to treat neurodisfunctions, such as stroke. This study was designed to assess the neuroprotective effects of lavender oil against ischemia/reperfusion (IR) injury in mice. Focal cerebral ischemia was induced by the intraluminal occlusion method with a nylon string. The neurodysfuntion was evaluated by neurological deficit and the infarct area was showed by 2,3,5-triphenyltetrazolium chloride (TTC) staining. The histopathological changes were observed by hematoxylin and eosin staining. The levels of mitochondria-generated reactive oxygen species (ROS), malondialdehyde (MDA) and carbonyl, the ratio of reduced glutathione (GSH)/glutathione disulfide (GSSG), the activities of superoxide dismutase (SOD), catalase (CAT) and glutathion peroxidase (GSH-Px) in brain tissue were measured to estimate the oxidative stress state. Neurological deficit, infarct size, histopathology changes and oxidative stress markers were evaluated after 22 h of reperfusion. In comparison with the model group, treatment with lavender oil significantly decreased neurological deficit scores, infarct size, the levels of MDA, carbonyl and ROS, and attenuated neuronal damage, upregulated SOD, CAT, GSH-Px activities and GSH/GSSG ratio. These results suggested that the neuroprotective effects of lavender oil against cerebral ischemia/reperfusion injury may be attributed to its antioxidant effects. |
| first_indexed | 2024-12-11T06:08:40Z |
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| id | doaj.art-50dba05fd2804a2eaaeb4d8b899a4633 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T06:08:40Z |
| publishDate | 2012-08-01 |
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| record_format | Article |
| series | Molecules |
| spelling | doaj.art-50dba05fd2804a2eaaeb4d8b899a46332022-12-22T01:18:12ZengMDPI AGMolecules1420-30492012-08-011789803981710.3390/molecules17089803Neuroprotective Activity of Lavender Oil on Transient Focal Cerebral Ischemia in MiceQiusheng ZhengZhenhua WangYanli HuLiangliang LiuDong WangXuan YuanTing LiuThe air-<em>dried aerial parts</em> of<em> Lavandula angustifolia</em> Mill, a traditional Uygur herbal drug, is used as resuscitation-inducing therapy to treat neurodisfunctions, such as stroke. This study was designed to assess the neuroprotective effects of lavender oil against ischemia/reperfusion (IR) injury in mice. Focal cerebral ischemia was induced by the intraluminal occlusion method with a nylon string. The neurodysfuntion was evaluated by neurological deficit and the infarct area was showed by 2,3,5-triphenyltetrazolium chloride (TTC) staining. The histopathological changes were observed by hematoxylin and eosin staining. The levels of mitochondria-generated reactive oxygen species (ROS), malondialdehyde (MDA) and carbonyl, the ratio of reduced glutathione (GSH)/glutathione disulfide (GSSG), the activities of superoxide dismutase (SOD), catalase (CAT) and glutathion peroxidase (GSH-Px) in brain tissue were measured to estimate the oxidative stress state. Neurological deficit, infarct size, histopathology changes and oxidative stress markers were evaluated after 22 h of reperfusion. In comparison with the model group, treatment with lavender oil significantly decreased neurological deficit scores, infarct size, the levels of MDA, carbonyl and ROS, and attenuated neuronal damage, upregulated SOD, CAT, GSH-Px activities and GSH/GSSG ratio. These results suggested that the neuroprotective effects of lavender oil against cerebral ischemia/reperfusion injury may be attributed to its antioxidant effects.http://www.mdpi.com/1420-3049/17/8/9803lavender oilcerebral ischemia/reperfusionoxidative damage；ROSantioxidant |
| spellingShingle | Qiusheng Zheng Zhenhua Wang Yanli Hu Liangliang Liu Dong Wang Xuan Yuan Ting Liu Neuroprotective Activity of Lavender Oil on Transient Focal Cerebral Ischemia in Mice Molecules lavender oil cerebral ischemia/reperfusion oxidative damage；ROS antioxidant |
| title | Neuroprotective Activity of Lavender Oil on Transient Focal Cerebral Ischemia in Mice |
| title_full | Neuroprotective Activity of Lavender Oil on Transient Focal Cerebral Ischemia in Mice |
| title_fullStr | Neuroprotective Activity of Lavender Oil on Transient Focal Cerebral Ischemia in Mice |
| title_full_unstemmed | Neuroprotective Activity of Lavender Oil on Transient Focal Cerebral Ischemia in Mice |
| title_short | Neuroprotective Activity of Lavender Oil on Transient Focal Cerebral Ischemia in Mice |
| title_sort | neuroprotective activity of lavender oil on transient focal cerebral ischemia in mice |
| topic | lavender oil cerebral ischemia/reperfusion oxidative damage；ROS antioxidant |
| url | http://www.mdpi.com/1420-3049/17/8/9803 |
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