Innate immune biology in age-related macular degeneration
Age-related macular degeneration (AMD) is a neurodegenerative disease and a leading cause of irreversible vision loss in the developed world. While not classically described as an inflammatory disease, a growing body of evidence has implicated several components of the innate immune system in the pa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1118524/full |
| _version_ | 1797893700042358784 |
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| author | Karina Ascunce Rahul M. Dhodapkar Deven Huang Brian P. Hafler Brian P. Hafler |
| author_facet | Karina Ascunce Rahul M. Dhodapkar Deven Huang Brian P. Hafler Brian P. Hafler |
| author_sort | Karina Ascunce |
| collection | DOAJ |
| description | Age-related macular degeneration (AMD) is a neurodegenerative disease and a leading cause of irreversible vision loss in the developed world. While not classically described as an inflammatory disease, a growing body of evidence has implicated several components of the innate immune system in the pathophysiology of age-related macular degeneration. In particular, complement activation, microglial involvement, and blood-retinal-barrier disruption have been shown to play key roles in disease progression, and subsequent vision loss. This review discusses the role of the innate immune system in age-related macular degeneration as well as recent developments in single-cell transcriptomics that help advance the understanding and treatment of age-related macular degeneration. We also explore the several potential therapeutic targets for age-related macular degeneration in the context of innate immune activation. |
| first_indexed | 2024-04-10T06:58:10Z |
| format | Article |
| id | doaj.art-50dba362ce5b48c0910effa1548e0689 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-10T06:58:10Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-50dba362ce5b48c0910effa1548e06892023-02-28T06:33:26ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-02-011110.3389/fcell.2023.11185241118524Innate immune biology in age-related macular degenerationKarina Ascunce0Rahul M. Dhodapkar1Deven Huang2Brian P. Hafler3Brian P. Hafler4Interdepartmental Neuroscience Program, Yale University, New Haven, CT, United StatesDepartment of Ophthalmology, Roski Eye Institute, University of Southern California, Los Angeles, CaliforniaChoate Rosemary Hall, Wallingford, CT, United StatesDepartment of Ophthalmology and Visual Science, Yale University, New Haven, CT, United StatesDepartment of Pathology, Yale University, New Haven, CT, United StatesAge-related macular degeneration (AMD) is a neurodegenerative disease and a leading cause of irreversible vision loss in the developed world. While not classically described as an inflammatory disease, a growing body of evidence has implicated several components of the innate immune system in the pathophysiology of age-related macular degeneration. In particular, complement activation, microglial involvement, and blood-retinal-barrier disruption have been shown to play key roles in disease progression, and subsequent vision loss. This review discusses the role of the innate immune system in age-related macular degeneration as well as recent developments in single-cell transcriptomics that help advance the understanding and treatment of age-related macular degeneration. We also explore the several potential therapeutic targets for age-related macular degeneration in the context of innate immune activation.https://www.frontiersin.org/articles/10.3389/fcell.2023.1118524/fullneuroinflammationage-related macular degeneration (AMD)neurodegenerationneuroimmune biologyinnate immunity |
| spellingShingle | Karina Ascunce Rahul M. Dhodapkar Deven Huang Brian P. Hafler Brian P. Hafler Innate immune biology in age-related macular degeneration Frontiers in Cell and Developmental Biology neuroinflammation age-related macular degeneration (AMD) neurodegeneration neuroimmune biology innate immunity |
| title | Innate immune biology in age-related macular degeneration |
| title_full | Innate immune biology in age-related macular degeneration |
| title_fullStr | Innate immune biology in age-related macular degeneration |
| title_full_unstemmed | Innate immune biology in age-related macular degeneration |
| title_short | Innate immune biology in age-related macular degeneration |
| title_sort | innate immune biology in age related macular degeneration |
| topic | neuroinflammation age-related macular degeneration (AMD) neurodegeneration neuroimmune biology innate immunity |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1118524/full |
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