Recent advances in alcoholic hepatitis [version 1; peer review: 3 approved]
Alcoholic hepatitis is the severest clinical presentation of alcoholic liver disease. Lacking an effective pharmacologic treatment, alcoholic hepatitis is associated with a poor prognosis and its recovery relies mostly on abstinence. With alcohol use disorder being universally on the rise, the impac...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2020-02-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/9-97/v1 |
| _version_ | 1828397525353103360 |
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| author | Vikrant Rachakonda Ramon Bataller Andres Duarte-Rojo |
| author_facet | Vikrant Rachakonda Ramon Bataller Andres Duarte-Rojo |
| author_sort | Vikrant Rachakonda |
| collection | DOAJ |
| description | Alcoholic hepatitis is the severest clinical presentation of alcoholic liver disease. Lacking an effective pharmacologic treatment, alcoholic hepatitis is associated with a poor prognosis and its recovery relies mostly on abstinence. With alcohol use disorder being universally on the rise, the impact of alcoholic hepatitis on society and health-care costs is expected to increase significantly. Prognostic factors and liver biopsy can help with timely diagnosis, to determine eligibility and response to corticosteroids, and for prognostication and transplant referral. Although recent discoveries in the pathophysiology of alcoholic hepatitis are encouraging and could pave the way for novel treatment modalities, a multidisciplinary approach considering timely identification and treatment of liver-related complications, infectious and metabolic disease, malnutrition, and addiction counseling should be emphasized. Apart from proper selection of candidates, transplant programs should provide adequate post-transplant addiction support in order to make of early liver transplantation for alcoholic hepatitis the ultimate sobering experience in the next decade. |
| first_indexed | 2024-12-10T08:49:19Z |
| format | Article |
| id | doaj.art-50dc11f0cc1c44dd9e8a4b7886004495 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-10T08:49:19Z |
| publishDate | 2020-02-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-50dc11f0cc1c44dd9e8a4b78860044952022-12-22T01:55:38ZengF1000 Research LtdF1000Research2046-14022020-02-01910.12688/f1000research.20394.122413Recent advances in alcoholic hepatitis [version 1; peer review: 3 approved]Vikrant Rachakonda0Ramon Bataller1Andres Duarte-Rojo2Division of Gastroenterology and Hepatology, Starzl Transplantation Institute, and Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, 15213, USADivision of Gastroenterology and Hepatology, Starzl Transplantation Institute, and Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, 15213, USADivision of Gastroenterology and Hepatology, Starzl Transplantation Institute, and Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, 15213, USAAlcoholic hepatitis is the severest clinical presentation of alcoholic liver disease. Lacking an effective pharmacologic treatment, alcoholic hepatitis is associated with a poor prognosis and its recovery relies mostly on abstinence. With alcohol use disorder being universally on the rise, the impact of alcoholic hepatitis on society and health-care costs is expected to increase significantly. Prognostic factors and liver biopsy can help with timely diagnosis, to determine eligibility and response to corticosteroids, and for prognostication and transplant referral. Although recent discoveries in the pathophysiology of alcoholic hepatitis are encouraging and could pave the way for novel treatment modalities, a multidisciplinary approach considering timely identification and treatment of liver-related complications, infectious and metabolic disease, malnutrition, and addiction counseling should be emphasized. Apart from proper selection of candidates, transplant programs should provide adequate post-transplant addiction support in order to make of early liver transplantation for alcoholic hepatitis the ultimate sobering experience in the next decade.https://f1000research.com/articles/9-97/v1 |
| spellingShingle | Vikrant Rachakonda Ramon Bataller Andres Duarte-Rojo Recent advances in alcoholic hepatitis [version 1; peer review: 3 approved] F1000Research |
| title | Recent advances in alcoholic hepatitis [version 1; peer review: 3 approved] |
| title_full | Recent advances in alcoholic hepatitis [version 1; peer review: 3 approved] |
| title_fullStr | Recent advances in alcoholic hepatitis [version 1; peer review: 3 approved] |
| title_full_unstemmed | Recent advances in alcoholic hepatitis [version 1; peer review: 3 approved] |
| title_short | Recent advances in alcoholic hepatitis [version 1; peer review: 3 approved] |
| title_sort | recent advances in alcoholic hepatitis version 1 peer review 3 approved |
| url | https://f1000research.com/articles/9-97/v1 |
| work_keys_str_mv | AT vikrantrachakonda recentadvancesinalcoholichepatitisversion1peerreview3approved AT ramonbataller recentadvancesinalcoholichepatitisversion1peerreview3approved AT andresduarterojo recentadvancesinalcoholichepatitisversion1peerreview3approved |