THE EFFECT OF HYDROGEL DRESSING COPOLYMER POLI(VINYLPIRROLIDONE) (PVP) - k- CARRAGEENAN PREPARED BY RADIATION AND HEALING TIMES ON THE RADIUS REDUCTIONS BURN INJURIED OF WISTAR WHITE RAT
The pre-clinical study of poly (vinyl pirrolidone) (PVP)-k- carrageenan hydrogel has been carried out. The aim of this study is to investigate the effect of hydrogel for healing burn injuried in the rats. The hydrogels were prepared by g-irradiation of aqueous solutions of 15 wt.-% PVP and 2 wt.-% k...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Department of Chemistry, Universitas Gadjah Mada
2010-06-01
|
| Series: | Indonesian Journal of Chemistry |
| Online Access: | https://jurnal.ugm.ac.id/ijc/article/view/21633 |
| _version_ | 1830178939154202624 |
|---|---|
| author | Erizal Erizal |
| author_facet | Erizal Erizal |
| author_sort | Erizal Erizal |
| collection | DOAJ |
| description | The pre-clinical study of poly (vinyl pirrolidone) (PVP)-k- carrageenan hydrogel has been carried out. The aim of this study is to investigate the effect of hydrogel for healing burn injuried in the rats. The hydrogels were prepared by g-irradiation of aqueous solutions of 15 wt.-% PVP and 2 wt.-% k- carrageenan at a sterilization dose of 25 kGy. The physico-chemical properties of hydrogels were investigated. The results showed that the hydrogels suitable as candidate for wound dressing with gel fraction of 90 ± 5 (%), the water absorption was 4500 ± 55 (w/w), the water content was 83 ± 2 (%), tensile strength was 1,5 ± 0,1 kg/cm2 and adhesiveness was 0. The effect of the hydrogel as wound dressing was evaluated by attaching to a burn of the back skin of rats as a function of time observation. Advantages of the hydrogel were slightly faster rate of reducing radius diameter of injured burn skin, easy removal without damage to renewed skin.
Keywords: hydrogel, irradiation, copolymer, PVP, k carrageenan, diameter |
| first_indexed | 2024-12-17T19:51:11Z |
| format | Article |
| id | doaj.art-50dc2d91114d4ef49259045d06652fb3 |
| institution | Directory Open Access Journal |
| issn | 1411-9420 2460-1578 |
| language | English |
| last_indexed | 2024-12-17T19:51:11Z |
| publishDate | 2010-06-01 |
| publisher | Department of Chemistry, Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Chemistry |
| spelling | doaj.art-50dc2d91114d4ef49259045d06652fb32022-12-21T21:34:43ZengDepartment of Chemistry, Universitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782010-06-018227127810.22146/ijc.2163314731THE EFFECT OF HYDROGEL DRESSING COPOLYMER POLI(VINYLPIRROLIDONE) (PVP) - k- CARRAGEENAN PREPARED BY RADIATION AND HEALING TIMES ON THE RADIUS REDUCTIONS BURN INJURIED OF WISTAR WHITE RATErizal Erizal0Centre for the Application Technology of Isotopes and Radiation, National Nuclear Energy Agency, Jl. Cinere Ps. Jumat PO BOX 7002, JKSKL 12070The pre-clinical study of poly (vinyl pirrolidone) (PVP)-k- carrageenan hydrogel has been carried out. The aim of this study is to investigate the effect of hydrogel for healing burn injuried in the rats. The hydrogels were prepared by g-irradiation of aqueous solutions of 15 wt.-% PVP and 2 wt.-% k- carrageenan at a sterilization dose of 25 kGy. The physico-chemical properties of hydrogels were investigated. The results showed that the hydrogels suitable as candidate for wound dressing with gel fraction of 90 ± 5 (%), the water absorption was 4500 ± 55 (w/w), the water content was 83 ± 2 (%), tensile strength was 1,5 ± 0,1 kg/cm2 and adhesiveness was 0. The effect of the hydrogel as wound dressing was evaluated by attaching to a burn of the back skin of rats as a function of time observation. Advantages of the hydrogel were slightly faster rate of reducing radius diameter of injured burn skin, easy removal without damage to renewed skin. Keywords: hydrogel, irradiation, copolymer, PVP, k carrageenan, diameterhttps://jurnal.ugm.ac.id/ijc/article/view/21633 |
| spellingShingle | Erizal Erizal THE EFFECT OF HYDROGEL DRESSING COPOLYMER POLI(VINYLPIRROLIDONE) (PVP) - k- CARRAGEENAN PREPARED BY RADIATION AND HEALING TIMES ON THE RADIUS REDUCTIONS BURN INJURIED OF WISTAR WHITE RAT Indonesian Journal of Chemistry |
| title | THE EFFECT OF HYDROGEL DRESSING COPOLYMER POLI(VINYLPIRROLIDONE) (PVP) - k- CARRAGEENAN PREPARED BY RADIATION AND HEALING TIMES ON THE RADIUS REDUCTIONS BURN INJURIED OF WISTAR WHITE RAT |
| title_full | THE EFFECT OF HYDROGEL DRESSING COPOLYMER POLI(VINYLPIRROLIDONE) (PVP) - k- CARRAGEENAN PREPARED BY RADIATION AND HEALING TIMES ON THE RADIUS REDUCTIONS BURN INJURIED OF WISTAR WHITE RAT |
| title_fullStr | THE EFFECT OF HYDROGEL DRESSING COPOLYMER POLI(VINYLPIRROLIDONE) (PVP) - k- CARRAGEENAN PREPARED BY RADIATION AND HEALING TIMES ON THE RADIUS REDUCTIONS BURN INJURIED OF WISTAR WHITE RAT |
| title_full_unstemmed | THE EFFECT OF HYDROGEL DRESSING COPOLYMER POLI(VINYLPIRROLIDONE) (PVP) - k- CARRAGEENAN PREPARED BY RADIATION AND HEALING TIMES ON THE RADIUS REDUCTIONS BURN INJURIED OF WISTAR WHITE RAT |
| title_short | THE EFFECT OF HYDROGEL DRESSING COPOLYMER POLI(VINYLPIRROLIDONE) (PVP) - k- CARRAGEENAN PREPARED BY RADIATION AND HEALING TIMES ON THE RADIUS REDUCTIONS BURN INJURIED OF WISTAR WHITE RAT |
| title_sort | effect of hydrogel dressing copolymer poli vinylpirrolidone pvp k carrageenan prepared by radiation and healing times on the radius reductions burn injuried of wistar white rat |
| url | https://jurnal.ugm.ac.id/ijc/article/view/21633 |
| work_keys_str_mv | AT erizalerizal theeffectofhydrogeldressingcopolymerpolivinylpirrolidonepvpkcarrageenanpreparedbyradiationandhealingtimesontheradiusreductionsburninjuriedofwistarwhiterat AT erizalerizal effectofhydrogeldressingcopolymerpolivinylpirrolidonepvpkcarrageenanpreparedbyradiationandhealingtimesontheradiusreductionsburninjuriedofwistarwhiterat |