IS A THIRD DOSE OF MEASLES VACCINE NECESSARY - AN IMMUNOLOGIST’S VIEW
Immunological aspects of features of post-vaccine immune response to measles virus are presented and causal relationships are detected, that lead to the disappearance of protective antibodies against measles virus, as one of the arguments for improvement of vaccination tactics with the aim to increa...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Central Research Institute for Epidemiology
2016-10-01
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| Series: | Журнал микробиологии, эпидемиологии и иммунобиологии |
| Subjects: | |
| Online Access: | https://microbiol.elpub.ru/jour/article/view/91 |
| _version_ | 1818081072818159616 |
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| author | M. P. Kostinov A. D. Shmitko I. L. Solovieva A. A. Savisko V. B. Polischuk A. A. Ryzhov A. P. Cherdantsev |
| author_facet | M. P. Kostinov A. D. Shmitko I. L. Solovieva A. A. Savisko V. B. Polischuk A. A. Ryzhov A. P. Cherdantsev |
| author_sort | M. P. Kostinov |
| collection | DOAJ |
| description | Immunological aspects of features of post-vaccine immune response to measles virus are presented and causal relationships are detected, that lead to the disappearance of protective antibodies against measles virus, as one of the arguments for improvement of vaccination tactics with the aim to increase immune population and enhancement of epidemiologic situation regarding measles in general. At contemporary stage during mass vaccinations against measles a portion of seronegatives among women of reproductive age and newborns (up to 20.1%) with an additional increase of this parameter by 8 - 13% during pathologic course of pregnancy is established. At the age of 12 months portion of seronegatives among children with health deviations reaches 80 - 90.0% against 53.8% - in healthy. Revaccination of children with deviation of health is shown not to result in production of antibodies against measles virus at protective titers in 30.4 - 33.3% of cases, that could facilitate formation of risk groups for measles virus infection during unfavorable epidemic situations. A problem of possible introduction of a third dose of the measles vaccine among the indicated population groups is discussed. |
| first_indexed | 2024-12-10T19:00:24Z |
| format | Article |
| id | doaj.art-50e12a4900e2491a8a8693037a176649 |
| institution | Directory Open Access Journal |
| issn | 0372-9311 2686-7613 |
| language | Russian |
| last_indexed | 2024-12-10T19:00:24Z |
| publishDate | 2016-10-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Журнал микробиологии, эпидемиологии и иммунобиологии |
| spelling | doaj.art-50e12a4900e2491a8a8693037a1766492022-12-22T01:37:01ZrusCentral Research Institute for EpidemiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-76132016-10-0105889410.36233/0372-9311-2016-5-88-9491IS A THIRD DOSE OF MEASLES VACCINE NECESSARY - AN IMMUNOLOGIST’S VIEWM. P. Kostinov0A. D. Shmitko1I. L. Solovieva2A. A. Savisko3V. B. Polischuk4A. A. Ryzhov5A. P. Cherdantsev6Mechnikov Research Institute of Vaccines and SeraMechnikov Research Institute of Vaccines and SeraUlyanovsk State UniversityRostov Medical UniversityMechnikov Research Institute of Vaccines and SeraMechnikov Research Institute of Vaccines and SeraUlyanovsk State UniversityImmunological aspects of features of post-vaccine immune response to measles virus are presented and causal relationships are detected, that lead to the disappearance of protective antibodies against measles virus, as one of the arguments for improvement of vaccination tactics with the aim to increase immune population and enhancement of epidemiologic situation regarding measles in general. At contemporary stage during mass vaccinations against measles a portion of seronegatives among women of reproductive age and newborns (up to 20.1%) with an additional increase of this parameter by 8 - 13% during pathologic course of pregnancy is established. At the age of 12 months portion of seronegatives among children with health deviations reaches 80 - 90.0% against 53.8% - in healthy. Revaccination of children with deviation of health is shown not to result in production of antibodies against measles virus at protective titers in 30.4 - 33.3% of cases, that could facilitate formation of risk groups for measles virus infection during unfavorable epidemic situations. A problem of possible introduction of a third dose of the measles vaccine among the indicated population groups is discussed.https://microbiol.elpub.ru/jour/article/view/91measlespost-vaccine immunityseronegativestransplacental antibodiespregnantnewbornsvaccination of frequently ill childrenvaccination during allegro-pathology |
| spellingShingle | M. P. Kostinov A. D. Shmitko I. L. Solovieva A. A. Savisko V. B. Polischuk A. A. Ryzhov A. P. Cherdantsev IS A THIRD DOSE OF MEASLES VACCINE NECESSARY - AN IMMUNOLOGIST’S VIEW Журнал микробиологии, эпидемиологии и иммунобиологии measles post-vaccine immunity seronegatives transplacental antibodies pregnant newborns vaccination of frequently ill children vaccination during allegro-pathology |
| title | IS A THIRD DOSE OF MEASLES VACCINE NECESSARY - AN IMMUNOLOGIST’S VIEW |
| title_full | IS A THIRD DOSE OF MEASLES VACCINE NECESSARY - AN IMMUNOLOGIST’S VIEW |
| title_fullStr | IS A THIRD DOSE OF MEASLES VACCINE NECESSARY - AN IMMUNOLOGIST’S VIEW |
| title_full_unstemmed | IS A THIRD DOSE OF MEASLES VACCINE NECESSARY - AN IMMUNOLOGIST’S VIEW |
| title_short | IS A THIRD DOSE OF MEASLES VACCINE NECESSARY - AN IMMUNOLOGIST’S VIEW |
| title_sort | is a third dose of measles vaccine necessary an immunologist s view |
| topic | measles post-vaccine immunity seronegatives transplacental antibodies pregnant newborns vaccination of frequently ill children vaccination during allegro-pathology |
| url | https://microbiol.elpub.ru/jour/article/view/91 |
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