Does ochratoxin A (OTA) cause testicular cancer in humans?
Ochratoxin A (OTA) is a naturally occurring contaminant of cereals, pigmeat, and other foods and is a known genotoxic in animals. It is a nephrotoxin and a carcinogen associated with Balkan endemic nephropathy and urinary tract tumours. It is also thought to be a cause of testicular cancer. A previo...
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| Format: | Article |
| Language: | English |
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Vilnius University Press
2011-01-01
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| Series: | Acta Medica Lituanica |
| Online Access: | https://www.journals.vu.lt/AML/article/view/21596 |
| _version_ | 1811272939377524736 |
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| author | Jayachandra SRINIVASA |
| author_facet | Jayachandra SRINIVASA |
| author_sort | Jayachandra SRINIVASA |
| collection | DOAJ |
| description | Ochratoxin A (OTA) is a naturally occurring contaminant of cereals, pigmeat, and other foods and is a known genotoxic in animals. It is a nephrotoxin and a carcinogen associated with Balkan endemic nephropathy and urinary tract tumours. It is also thought to be a cause of testicular cancer. A previous study has shown that consumption of foods contaminated with ochratoxin A during pregnancy induces lesions in testicular DNA of male offspring, and this supports a possible role for OTA in testicular cancer. Additionally, prenatal exposure to ochratoxin A in mice significantly depresses expression of the DMRT1 gene in male offspring, and the loss of this gene produces germ cell testicular tumours in mice. This molecular evidence supports the theory that ochratoxin A might be related to germ cell testicular tumours in mice and in humans.
Keywords: ochratoxin A, testicular cancer, mycotoxins |
| first_indexed | 2024-04-12T22:49:07Z |
| format | Article |
| id | doaj.art-50e316d6d06d41c3bb916b50d28df943 |
| institution | Directory Open Access Journal |
| issn | 1392-0138 2029-4174 |
| language | English |
| last_indexed | 2024-04-12T22:49:07Z |
| publishDate | 2011-01-01 |
| publisher | Vilnius University Press |
| record_format | Article |
| series | Acta Medica Lituanica |
| spelling | doaj.art-50e316d6d06d41c3bb916b50d28df9432022-12-22T03:13:25ZengVilnius University PressActa Medica Lituanica1392-01382029-41742011-01-0118110.6001/actamedica.v18i1.1806Does ochratoxin A (OTA) cause testicular cancer in humans?Jayachandra SRINIVASAOchratoxin A (OTA) is a naturally occurring contaminant of cereals, pigmeat, and other foods and is a known genotoxic in animals. It is a nephrotoxin and a carcinogen associated with Balkan endemic nephropathy and urinary tract tumours. It is also thought to be a cause of testicular cancer. A previous study has shown that consumption of foods contaminated with ochratoxin A during pregnancy induces lesions in testicular DNA of male offspring, and this supports a possible role for OTA in testicular cancer. Additionally, prenatal exposure to ochratoxin A in mice significantly depresses expression of the DMRT1 gene in male offspring, and the loss of this gene produces germ cell testicular tumours in mice. This molecular evidence supports the theory that ochratoxin A might be related to germ cell testicular tumours in mice and in humans. Keywords: ochratoxin A, testicular cancer, mycotoxinshttps://www.journals.vu.lt/AML/article/view/21596 |
| spellingShingle | Jayachandra SRINIVASA Does ochratoxin A (OTA) cause testicular cancer in humans? Acta Medica Lituanica |
| title | Does ochratoxin A (OTA) cause testicular cancer in humans? |
| title_full | Does ochratoxin A (OTA) cause testicular cancer in humans? |
| title_fullStr | Does ochratoxin A (OTA) cause testicular cancer in humans? |
| title_full_unstemmed | Does ochratoxin A (OTA) cause testicular cancer in humans? |
| title_short | Does ochratoxin A (OTA) cause testicular cancer in humans? |
| title_sort | does ochratoxin a ota cause testicular cancer in humans |
| url | https://www.journals.vu.lt/AML/article/view/21596 |
| work_keys_str_mv | AT jayachandrasrinivasa doesochratoxinaotacausetesticularcancerinhumans |