Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells.

Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells.

Polycomb-group RING finger proteins (Pcgf1-Pcgf6) are components of Polycomb repressive complex 1 (PRC1)-related complexes that catalyze monoubiquitination of histone H2A at lysine 119 (H2AK119ub1), an epigenetic mark associated with repression of genes. Pcgf5 has been characterized as a component o...

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Detalles Bibliográficos
Main Authors: Sha Si, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Motohiko Oshima, Atsunori Saraya, Hiroki Sugishita, Manabu Nakayama, Tomoyuki Ishikura, Haruhiko Koseki, Atsushi Iwama
Formato: Artigo
Idioma:English
Publicado: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Acceso en liña:http://europepmc.org/articles/PMC4852895?pdf=render

Internet

http://europepmc.org/articles/PMC4852895?pdf=render

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