Current and future applications of fecal microbiota transplantation for children
Fecal microbiota transplantation (FMT) is a new and adequate route to modify the microbial ecosystem in gastrointestinal tract of the hosts. Intestinal microbiota is highly associated with human health and disease. According to the reports of human clinical trials or case series, the application of...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-02-01
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| Series: | Biomedical Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2319417021001530 |
| _version_ | 1798037647468265472 |
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| author | Chien-Chang Chen Cheng-Hsun Chiu |
| author_facet | Chien-Chang Chen Cheng-Hsun Chiu |
| author_sort | Chien-Chang Chen |
| collection | DOAJ |
| description | Fecal microbiota transplantation (FMT) is a new and adequate route to modify the microbial ecosystem in gastrointestinal tract of the hosts. Intestinal microbiota is highly associated with human health and disease. According to the reports of human clinical trials or case series, the application of FMT ranged from Clostridiodes difficile infection (CDI), inflammatory bowel disease (IBD), irritable bowel syndrome, refractory diarrhea, diabetes mellitus, metabolic syndrome, and even neurologic diseases, including Parkinson disease, and neuropsychiatric disorder (autism spectrum disorder, ASD). Although the current allowed indication of FMT is CDI in Taiwan, more application and development are expectable in the future. There is a relative rare data available for children in application of fecal microbiota transplantation. Thus, we review previous published research inspecting FMT in children, and address particular considerations when conducting FMT in pediatric patients. |
| first_indexed | 2024-04-11T21:29:23Z |
| format | Article |
| id | doaj.art-50e4a19235bd4c14af0e11a3934bb6c0 |
| institution | Directory Open Access Journal |
| issn | 2319-4170 |
| language | English |
| last_indexed | 2024-04-11T21:29:23Z |
| publishDate | 2022-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj.art-50e4a19235bd4c14af0e11a3934bb6c02022-12-22T04:02:13ZengElsevierBiomedical Journal2319-41702022-02-014511118Current and future applications of fecal microbiota transplantation for childrenChien-Chang Chen0Cheng-Hsun Chiu1Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, TaiwanMolecular Infectious Disease Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Corresponding author. Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, 5, Fuxing St., Gueishan, Taoyuan 333, Taiwan. Tele.: +886 3 3281200 ext 8896. Fax: +886 3 3288957.Fecal microbiota transplantation (FMT) is a new and adequate route to modify the microbial ecosystem in gastrointestinal tract of the hosts. Intestinal microbiota is highly associated with human health and disease. According to the reports of human clinical trials or case series, the application of FMT ranged from Clostridiodes difficile infection (CDI), inflammatory bowel disease (IBD), irritable bowel syndrome, refractory diarrhea, diabetes mellitus, metabolic syndrome, and even neurologic diseases, including Parkinson disease, and neuropsychiatric disorder (autism spectrum disorder, ASD). Although the current allowed indication of FMT is CDI in Taiwan, more application and development are expectable in the future. There is a relative rare data available for children in application of fecal microbiota transplantation. Thus, we review previous published research inspecting FMT in children, and address particular considerations when conducting FMT in pediatric patients.http://www.sciencedirect.com/science/article/pii/S2319417021001530Fecal microbiota transplantation (FMT)Clostridiodes difficile infection (CDI)Inflammatory bowel disease (IBD)Autism spectrum disorder (ASD)Children |
| spellingShingle | Chien-Chang Chen Cheng-Hsun Chiu Current and future applications of fecal microbiota transplantation for children Biomedical Journal Fecal microbiota transplantation (FMT) Clostridiodes difficile infection (CDI) Inflammatory bowel disease (IBD) Autism spectrum disorder (ASD) Children |
| title | Current and future applications of fecal microbiota transplantation for children |
| title_full | Current and future applications of fecal microbiota transplantation for children |
| title_fullStr | Current and future applications of fecal microbiota transplantation for children |
| title_full_unstemmed | Current and future applications of fecal microbiota transplantation for children |
| title_short | Current and future applications of fecal microbiota transplantation for children |
| title_sort | current and future applications of fecal microbiota transplantation for children |
| topic | Fecal microbiota transplantation (FMT) Clostridiodes difficile infection (CDI) Inflammatory bowel disease (IBD) Autism spectrum disorder (ASD) Children |
| url | http://www.sciencedirect.com/science/article/pii/S2319417021001530 |
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