Unraveling the occupational exposure to mycotoxins in a waste management setting: results from a case study in Norway
IntroductionWaste management represents an occupational setting where fungi are significant contaminants. This study aimed to assess the exposure of waste workers to mycotoxins through a human biomonitoring study.MethodsA total of 33 workers and 19 controls provided spot urine samples to determine 1...
| Hlavní autoři: | , , , , , , , , , |
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| Médium: | Článek |
| Jazyk: | English |
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Frontiers Media S.A.
2025-02-01
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| Edice: | Frontiers in Public Health |
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| On-line přístup: | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1536836/full |
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| author | Carla Martins Carla Viegas Elke Eriksen Elke Eriksen Pål Graff Anani Komlavi Afanou Anne Straumfors Magdalena Twarużek Jan Grajewski Robert Kosicki Susana Viegas |
| author_facet | Carla Martins Carla Viegas Elke Eriksen Elke Eriksen Pål Graff Anani Komlavi Afanou Anne Straumfors Magdalena Twarużek Jan Grajewski Robert Kosicki Susana Viegas |
| author_sort | Carla Martins |
| collection | DOAJ |
| description | IntroductionWaste management represents an occupational setting where fungi are significant contaminants. This study aimed to assess the exposure of waste workers to mycotoxins through a human biomonitoring study.MethodsA total of 33 workers and 19 controls provided spot urine samples to determine 10 mycotoxins’ urinary biomarkers using liquid chromatography coupled with mass spectrometry. Risk characterization was performed using hazard quotient and margin of exposure assessments.ResultsThe results indicated that workers were exposed to six out of the 10 mycotoxins tested, with the following detection rates: deoxynivalenol (91%, 30/33), ochratoxin A (33%, 11/33), zearalenone (17%, 5/33), α-zearalenol (12%, 4/33), β-zearalenol (12%, 4/33), and HT-2 toxin (3%, 1/33). Within controls and outwith controls, were exposed to 5/10 and 2/10 mycotoxins, respectively. All participants exhibited hazard quotients for deoxynivalenol and zearalenone below one, indicating that the exposure is unlikely to pose a health risk. However, when considering the margin of exposure determined for ochratoxin A, 18% of the total participants presented results below 200 for non-neoplastic effects, and 100% of the total participants presented values below 10,000 for neoplastic effects, suggesting potential health concerns that require further assessment.DiscussionThis study highlights the need for future research on occupational exposure to mycotoxins in waste management settings. |
| first_indexed | 2025-03-17T02:08:40Z |
| format | Article |
| id | doaj.art-50e4ce1d5a684033a4c8f3e166d90c3c |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2025-03-17T02:08:40Z |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-50e4ce1d5a684033a4c8f3e166d90c3c2025-02-13T07:08:03ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-02-011310.3389/fpubh.2025.15368361536836Unraveling the occupational exposure to mycotoxins in a waste management setting: results from a case study in NorwayCarla Martins0Carla Viegas1Elke Eriksen2Elke Eriksen3Pål Graff4Anani Komlavi Afanou5Anne Straumfors6Magdalena Twarużek7Jan Grajewski8Robert Kosicki9Susana Viegas10NOVA National School of Public Health, Public Health Research Centre, Comprehensive Health Research Center, CHRC, REAL, CCAL, NOVA University Lisbon, Lisbon, PortugalH&TRC–Health and Technology Research Center, ESTeSL–Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisbon, PortugalNOVA National School of Public Health, Public Health Research Centre, Comprehensive Health Research Center, CHRC, REAL, CCAL, NOVA University Lisbon, Lisbon, PortugalH&TRC–Health and Technology Research Center, ESTeSL–Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisbon, PortugalNational Institute of Occupational Health (STAMI), Oslo, NorwayNational Institute of Occupational Health (STAMI), Oslo, NorwayNational Institute of Occupational Health (STAMI), Oslo, NorwayDepartment of Physiology and Toxicology, Faculty of Biological Sciences, Kazimierz Wielki University, Bydgoszcz, PolandDepartment of Physiology and Toxicology, Faculty of Biological Sciences, Kazimierz Wielki University, Bydgoszcz, PolandDepartment of Physiology and Toxicology, Faculty of Biological Sciences, Kazimierz Wielki University, Bydgoszcz, PolandNOVA National School of Public Health, Public Health Research Centre, Comprehensive Health Research Center, CHRC, REAL, CCAL, NOVA University Lisbon, Lisbon, PortugalIntroductionWaste management represents an occupational setting where fungi are significant contaminants. This study aimed to assess the exposure of waste workers to mycotoxins through a human biomonitoring study.MethodsA total of 33 workers and 19 controls provided spot urine samples to determine 10 mycotoxins’ urinary biomarkers using liquid chromatography coupled with mass spectrometry. Risk characterization was performed using hazard quotient and margin of exposure assessments.ResultsThe results indicated that workers were exposed to six out of the 10 mycotoxins tested, with the following detection rates: deoxynivalenol (91%, 30/33), ochratoxin A (33%, 11/33), zearalenone (17%, 5/33), α-zearalenol (12%, 4/33), β-zearalenol (12%, 4/33), and HT-2 toxin (3%, 1/33). Within controls and outwith controls, were exposed to 5/10 and 2/10 mycotoxins, respectively. All participants exhibited hazard quotients for deoxynivalenol and zearalenone below one, indicating that the exposure is unlikely to pose a health risk. However, when considering the margin of exposure determined for ochratoxin A, 18% of the total participants presented results below 200 for non-neoplastic effects, and 100% of the total participants presented values below 10,000 for neoplastic effects, suggesting potential health concerns that require further assessment.DiscussionThis study highlights the need for future research on occupational exposure to mycotoxins in waste management settings.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1536836/fullmycotoxinsoccupational hygienewaste managementhuman biomonitoringexposure assessment |
| spellingShingle | Carla Martins Carla Viegas Elke Eriksen Elke Eriksen Pål Graff Anani Komlavi Afanou Anne Straumfors Magdalena Twarużek Jan Grajewski Robert Kosicki Susana Viegas Unraveling the occupational exposure to mycotoxins in a waste management setting: results from a case study in Norway Frontiers in Public Health mycotoxins occupational hygiene waste management human biomonitoring exposure assessment |
| title | Unraveling the occupational exposure to mycotoxins in a waste management setting: results from a case study in Norway |
| title_full | Unraveling the occupational exposure to mycotoxins in a waste management setting: results from a case study in Norway |
| title_fullStr | Unraveling the occupational exposure to mycotoxins in a waste management setting: results from a case study in Norway |
| title_full_unstemmed | Unraveling the occupational exposure to mycotoxins in a waste management setting: results from a case study in Norway |
| title_short | Unraveling the occupational exposure to mycotoxins in a waste management setting: results from a case study in Norway |
| title_sort | unraveling the occupational exposure to mycotoxins in a waste management setting results from a case study in norway |
| topic | mycotoxins occupational hygiene waste management human biomonitoring exposure assessment |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1536836/full |
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