Change in kidney volume after kidney transplantation in patients with autosomal polycystic kidney disease.
<h4>Background</h4>The indication to bilateral nephrectomy in patients with autosomal dominant polycystic kidney scheduled for kidney transplantation is controversial. Indeed, the progressive enlargement of cysts may increase the risk of complications and the need for nephrectomy. Howeve...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0209332 |
| _version_ | 1819037066206380032 |
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| author | Massimiliano Veroux Cecilia Gozzo Daniela Corona Paolo Murabito Daniele Carmelo Caltabiano Luca Mammino Alessia Giaquinta Domenico Zerbo Nunziata Sinagra Pierfrancesco Veroux Stefano Palmucci |
| author_facet | Massimiliano Veroux Cecilia Gozzo Daniela Corona Paolo Murabito Daniele Carmelo Caltabiano Luca Mammino Alessia Giaquinta Domenico Zerbo Nunziata Sinagra Pierfrancesco Veroux Stefano Palmucci |
| author_sort | Massimiliano Veroux |
| collection | DOAJ |
| description | <h4>Background</h4>The indication to bilateral nephrectomy in patients with autosomal dominant polycystic kidney scheduled for kidney transplantation is controversial. Indeed, the progressive enlargement of cysts may increase the risk of complications and the need for nephrectomy. However, very few studies investigated the change in kidney volume after kidney transplantation.<h4>Material and methods</h4>In this prospective cohort study, the change in native kidney volume in polycystic patients was evaluated with magnetic resonance imaging. Forty patients were included in the study. Kidney diameters and total kidney volume were evaluated with magnetic resonance imaging in patients who underwent simultaneous nephrectomy and kidney transplantation and in patients with kidney transplant alone, before transplantation and 1 year after transplantation.<h4>Results</h4>There was a significant reduction of kidney volume after transplantation, with a mean degree of kidney diameters reduction varying from 12.24% to 14.43%. Mean total kidney volume of the 55 kidney considered in the analysis significantly reduced from 1617.94 ± 833.42 ml to 1381.42 ± 1005.73 ml (P<0.05), with a mean rate of 16.44% of volume decrease. More than 80% of patients had a volume reduction in both groups.<h4>Conclusions</h4>Polycystic kidneys volume significantly reduces after kidney transplantation, and this would reduce the need for prophylactic bilateral nephrectomy in asymptomatic patients. |
| first_indexed | 2024-12-21T08:15:30Z |
| format | Article |
| id | doaj.art-50e527fc8a3c45879ed60b8ba9f10648 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T08:15:30Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-50e527fc8a3c45879ed60b8ba9f106482022-12-21T19:10:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011312e020933210.1371/journal.pone.0209332Change in kidney volume after kidney transplantation in patients with autosomal polycystic kidney disease.Massimiliano VerouxCecilia GozzoDaniela CoronaPaolo MurabitoDaniele Carmelo CaltabianoLuca MamminoAlessia GiaquintaDomenico ZerboNunziata SinagraPierfrancesco VerouxStefano Palmucci<h4>Background</h4>The indication to bilateral nephrectomy in patients with autosomal dominant polycystic kidney scheduled for kidney transplantation is controversial. Indeed, the progressive enlargement of cysts may increase the risk of complications and the need for nephrectomy. However, very few studies investigated the change in kidney volume after kidney transplantation.<h4>Material and methods</h4>In this prospective cohort study, the change in native kidney volume in polycystic patients was evaluated with magnetic resonance imaging. Forty patients were included in the study. Kidney diameters and total kidney volume were evaluated with magnetic resonance imaging in patients who underwent simultaneous nephrectomy and kidney transplantation and in patients with kidney transplant alone, before transplantation and 1 year after transplantation.<h4>Results</h4>There was a significant reduction of kidney volume after transplantation, with a mean degree of kidney diameters reduction varying from 12.24% to 14.43%. Mean total kidney volume of the 55 kidney considered in the analysis significantly reduced from 1617.94 ± 833.42 ml to 1381.42 ± 1005.73 ml (P<0.05), with a mean rate of 16.44% of volume decrease. More than 80% of patients had a volume reduction in both groups.<h4>Conclusions</h4>Polycystic kidneys volume significantly reduces after kidney transplantation, and this would reduce the need for prophylactic bilateral nephrectomy in asymptomatic patients.https://doi.org/10.1371/journal.pone.0209332 |
| spellingShingle | Massimiliano Veroux Cecilia Gozzo Daniela Corona Paolo Murabito Daniele Carmelo Caltabiano Luca Mammino Alessia Giaquinta Domenico Zerbo Nunziata Sinagra Pierfrancesco Veroux Stefano Palmucci Change in kidney volume after kidney transplantation in patients with autosomal polycystic kidney disease. PLoS ONE |
| title | Change in kidney volume after kidney transplantation in patients with autosomal polycystic kidney disease. |
| title_full | Change in kidney volume after kidney transplantation in patients with autosomal polycystic kidney disease. |
| title_fullStr | Change in kidney volume after kidney transplantation in patients with autosomal polycystic kidney disease. |
| title_full_unstemmed | Change in kidney volume after kidney transplantation in patients with autosomal polycystic kidney disease. |
| title_short | Change in kidney volume after kidney transplantation in patients with autosomal polycystic kidney disease. |
| title_sort | change in kidney volume after kidney transplantation in patients with autosomal polycystic kidney disease |
| url | https://doi.org/10.1371/journal.pone.0209332 |
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