Dragon Fruits as a Reservoir of Natural Polyphenolics with Chemopreventive Properties
Dragon fruits are a valued source of bioactive compounds with high potential to become a functional food. The aim of the study was to evaluate and compare the chemopreventive potential and chemical composition of fruits harvested in Thailand and Israel. The amount of different compounds in water and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/8/2158 |
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| author | Paweł Paśko Agnieszka Galanty Paweł Zagrodzki Patraporn Luksirikul Dinorah Barasch Alina Nemirovski Shela Gorinstein |
| author_facet | Paweł Paśko Agnieszka Galanty Paweł Zagrodzki Patraporn Luksirikul Dinorah Barasch Alina Nemirovski Shela Gorinstein |
| author_sort | Paweł Paśko |
| collection | DOAJ |
| description | Dragon fruits are a valued source of bioactive compounds with high potential to become a functional food. The aim of the study was to evaluate and compare the chemopreventive potential and chemical composition of fruits harvested in Thailand and Israel. The amount of different compounds in water and methanol extracts and antioxidant activity was investigated. Moreover, cytotoxic activity against cancer and normal cells of skin, prostate, and gastrointestinal origin was performed, accompanied by anti-inflammatory assay based on NO production in RAW 264.7 macrophage model. Additionally, the quenching properties of polyphenols from fruits were determined by the interaction of the main drug carrier in blood human serum (HSA). The chemometric analysis was used to reveal the relationships between the determined parameters. Dragon fruits harvested in Israel revealed higher antioxidant properties and total content of polyphenols and betacyanins when compared to those from Thailand. The examined fruits of both origins showed significant cytotoxic activity toward colon and prostate cancer cells, with no toxic effect on normal cells, but also no anti-inflammatory effect. Moreover, a high binding ability to HSA was observed for water extracts of dragon fruits. All these predestine dragon fruits are the candidates for the attractive and chemopreventive elements of daily diet. |
| first_indexed | 2024-03-10T12:28:54Z |
| format | Article |
| id | doaj.art-50e6b6a6d60143e388de7a9d1a5bd04d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T12:28:54Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-50e6b6a6d60143e388de7a9d1a5bd04d2023-11-21T14:47:40ZengMDPI AGMolecules1420-30492021-04-01268215810.3390/molecules26082158Dragon Fruits as a Reservoir of Natural Polyphenolics with Chemopreventive PropertiesPaweł Paśko0Agnieszka Galanty1Paweł Zagrodzki2Patraporn Luksirikul3Dinorah Barasch4Alina Nemirovski5Shela Gorinstein6Department of Food Chemistry and Nutrition, Jagiellonian University Medical College, 31-008 Kraków, PolandDepartment of Pharmacognosy, Jagiellonian University Medical College, 31-008 Kraków, PolandDepartment of Food Chemistry and Nutrition, Jagiellonian University Medical College, 31-008 Kraków, PolandDepartment of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, ThailandInstitute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, IsraelInstitute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, IsraelInstitute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, IsraelDragon fruits are a valued source of bioactive compounds with high potential to become a functional food. The aim of the study was to evaluate and compare the chemopreventive potential and chemical composition of fruits harvested in Thailand and Israel. The amount of different compounds in water and methanol extracts and antioxidant activity was investigated. Moreover, cytotoxic activity against cancer and normal cells of skin, prostate, and gastrointestinal origin was performed, accompanied by anti-inflammatory assay based on NO production in RAW 264.7 macrophage model. Additionally, the quenching properties of polyphenols from fruits were determined by the interaction of the main drug carrier in blood human serum (HSA). The chemometric analysis was used to reveal the relationships between the determined parameters. Dragon fruits harvested in Israel revealed higher antioxidant properties and total content of polyphenols and betacyanins when compared to those from Thailand. The examined fruits of both origins showed significant cytotoxic activity toward colon and prostate cancer cells, with no toxic effect on normal cells, but also no anti-inflammatory effect. Moreover, a high binding ability to HSA was observed for water extracts of dragon fruits. All these predestine dragon fruits are the candidates for the attractive and chemopreventive elements of daily diet.https://www.mdpi.com/1420-3049/26/8/2158dragon fruitscytotoxicityinteraction with drug carrierantioxidant activityanti-inflammatory activity |
| spellingShingle | Paweł Paśko Agnieszka Galanty Paweł Zagrodzki Patraporn Luksirikul Dinorah Barasch Alina Nemirovski Shela Gorinstein Dragon Fruits as a Reservoir of Natural Polyphenolics with Chemopreventive Properties Molecules dragon fruits cytotoxicity interaction with drug carrier antioxidant activity anti-inflammatory activity |
| title | Dragon Fruits as a Reservoir of Natural Polyphenolics with Chemopreventive Properties |
| title_full | Dragon Fruits as a Reservoir of Natural Polyphenolics with Chemopreventive Properties |
| title_fullStr | Dragon Fruits as a Reservoir of Natural Polyphenolics with Chemopreventive Properties |
| title_full_unstemmed | Dragon Fruits as a Reservoir of Natural Polyphenolics with Chemopreventive Properties |
| title_short | Dragon Fruits as a Reservoir of Natural Polyphenolics with Chemopreventive Properties |
| title_sort | dragon fruits as a reservoir of natural polyphenolics with chemopreventive properties |
| topic | dragon fruits cytotoxicity interaction with drug carrier antioxidant activity anti-inflammatory activity |
| url | https://www.mdpi.com/1420-3049/26/8/2158 |
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