D-dimer in the Diagnosis of Prostate Cancer
Objective: To investigate the value of D-dimer, a marker of fibrinolysis, in metastatic and non-metastatic prostate cancer. Materials and Methods: A retrospective analysis was performed on 138 male patients including 52 patients with prostate cancer and 86 with benign prostatic hyperplasia. Parti...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ekrem Güner
2021-05-01
|
| Series: | Grand Journal of Urology |
| Subjects: | |
| Online Access: | https://grandjournalofurology.com/uploads/pdf/pdf_GJU_28.pdf |
| _version_ | 1797893700260462592 |
|---|---|
| author | Hasan Salih Saglam Haci Ibrahim Cimen |
| author_facet | Hasan Salih Saglam Haci Ibrahim Cimen |
| author_sort | Hasan Salih Saglam |
| collection | DOAJ |
| description | Objective: To investigate the value of D-dimer, a marker of fibrinolysis, in metastatic and non-metastatic prostate cancer.
Materials and Methods: A retrospective analysis was performed on 138 male patients including 52 patients with prostate cancer and 86 with benign prostatic hyperplasia. Participants who had factors that altered D-dimer levels were excluded. The mean ages of the groups were similar (70 ± 8 vs 68 ± 8, p= NS). In addition, data regarding biochemical findings, prostate-specific antigen and hemostatic markers, including D-dimer, were retrieved from the database of our hospital. The cut-off point of D-dimer was 0.5 mg/L. Data from scintigraphy and magnetic resonance imaging (MRI) scans related to metastasis were also considered. Patients who showed findings of metastasis according to scintigraphy and lumbosacral MRI were accepted as having metastases. Positive findings in only scintigraphy in any area were considered suspicious for metastasis.
Results: Patients with prostate cancer had higher D-dimer levels than benign prostate hyperplasia patients (p= 0.024). Sixteen patients with metastatic prostate cancer and suspicious for metastasis had markedly high D-dimer levels compared to benign prostate hyperplasia and non-metastatic prostate cancer patients.
Conclusion: prostate cancer, especially when metastatic, may increase D-dimer levels. |
| first_indexed | 2024-04-10T06:57:02Z |
| format | Article |
| id | doaj.art-50e6e1b20fa044afa58e1b2cd5b38d19 |
| institution | Directory Open Access Journal |
| issn | 2757-7163 |
| language | English |
| last_indexed | 2024-04-10T06:57:02Z |
| publishDate | 2021-05-01 |
| publisher | Ekrem Güner |
| record_format | Article |
| series | Grand Journal of Urology |
| spelling | doaj.art-50e6e1b20fa044afa58e1b2cd5b38d192023-02-28T07:17:43ZengEkrem GünerGrand Journal of Urology2757-71632021-05-0112667010.5222/GJU.2021.39974D-dimer in the Diagnosis of Prostate CancerHasan Salih Saglam0https://orcid.org/0000-0002-8904-1612Haci Ibrahim Cimen1https://orcid.org/0000-0002-0824-3926Department of Urology, Sakarya University Faculty of Medicine, Training and Research Hospital, Adapazari, Sakarya, TurkeyDepartment of Urology, Sakarya University Faculty of Medicine, Training and Research Hospital, Adapazari, Sakarya, TurkeyObjective: To investigate the value of D-dimer, a marker of fibrinolysis, in metastatic and non-metastatic prostate cancer. Materials and Methods: A retrospective analysis was performed on 138 male patients including 52 patients with prostate cancer and 86 with benign prostatic hyperplasia. Participants who had factors that altered D-dimer levels were excluded. The mean ages of the groups were similar (70 ± 8 vs 68 ± 8, p= NS). In addition, data regarding biochemical findings, prostate-specific antigen and hemostatic markers, including D-dimer, were retrieved from the database of our hospital. The cut-off point of D-dimer was 0.5 mg/L. Data from scintigraphy and magnetic resonance imaging (MRI) scans related to metastasis were also considered. Patients who showed findings of metastasis according to scintigraphy and lumbosacral MRI were accepted as having metastases. Positive findings in only scintigraphy in any area were considered suspicious for metastasis. Results: Patients with prostate cancer had higher D-dimer levels than benign prostate hyperplasia patients (p= 0.024). Sixteen patients with metastatic prostate cancer and suspicious for metastasis had markedly high D-dimer levels compared to benign prostate hyperplasia and non-metastatic prostate cancer patients. Conclusion: prostate cancer, especially when metastatic, may increase D-dimer levels.https://grandjournalofurology.com/uploads/pdf/pdf_GJU_28.pdfd-dimerprostate cancermetastasis |
| spellingShingle | Hasan Salih Saglam Haci Ibrahim Cimen D-dimer in the Diagnosis of Prostate Cancer Grand Journal of Urology d-dimer prostate cancer metastasis |
| title | D-dimer in the Diagnosis of Prostate Cancer |
| title_full | D-dimer in the Diagnosis of Prostate Cancer |
| title_fullStr | D-dimer in the Diagnosis of Prostate Cancer |
| title_full_unstemmed | D-dimer in the Diagnosis of Prostate Cancer |
| title_short | D-dimer in the Diagnosis of Prostate Cancer |
| title_sort | d dimer in the diagnosis of prostate cancer |
| topic | d-dimer prostate cancer metastasis |
| url | https://grandjournalofurology.com/uploads/pdf/pdf_GJU_28.pdf |
| work_keys_str_mv | AT hasansalihsaglam ddimerinthediagnosisofprostatecancer AT haciibrahimcimen ddimerinthediagnosisofprostatecancer |