Breast Cancer Drug Approvals Issued by EMA: A Review of Clinical Trials
Breast cancer represents the first cause of cancer worldwide and the leading cause of cancer mortality for women. Therefore, new therapies are needed to improve the prognosis of women diagnosed with this disease. In this review, we summarize the new drug indications for the treatment of breast cance...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/20/5198 |
| _version_ | 1797515067523072000 |
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| author | Simona Duranti Alessandra Fabi Marco Filetti Rosa Falcone Pasquale Lombardi Gennaro Daniele Gianluca Franceschini Luisa Carbognin Antonella Palazzo Giorgia Garganese Ida Paris Giovanni Scambia Antonella Pietragalla |
| author_facet | Simona Duranti Alessandra Fabi Marco Filetti Rosa Falcone Pasquale Lombardi Gennaro Daniele Gianluca Franceschini Luisa Carbognin Antonella Palazzo Giorgia Garganese Ida Paris Giovanni Scambia Antonella Pietragalla |
| author_sort | Simona Duranti |
| collection | DOAJ |
| description | Breast cancer represents the first cause of cancer worldwide and the leading cause of cancer mortality for women. Therefore, new therapies are needed to improve the prognosis of women diagnosed with this disease. In this review, we summarize the new drug indications for the treatment of breast cancer approved by European Medicines Agency between January 2015 and June 2021. In particular, we analyzed the clinical trials results leading to approvals and their update (when available), according to setting (localized and locally advanced or metastatic) and clinical features (hormone receptor positive, HER2 positive, triple negative, BRCA 1/2 mutation). The aim of this paper is to describe the clinical benefit obtained with the new indications. |
| first_indexed | 2024-03-10T06:40:22Z |
| format | Article |
| id | doaj.art-50e76add363a49dea77f2a4f489271bc |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T06:40:22Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-50e76add363a49dea77f2a4f489271bc2023-11-22T17:41:56ZengMDPI AGCancers2072-66942021-10-011320519810.3390/cancers13205198Breast Cancer Drug Approvals Issued by EMA: A Review of Clinical TrialsSimona Duranti0Alessandra Fabi1Marco Filetti2Rosa Falcone3Pasquale Lombardi4Gennaro Daniele5Gianluca Franceschini6Luisa Carbognin7Antonella Palazzo8Giorgia Garganese9Ida Paris10Giovanni Scambia11Antonella Pietragalla12Scientific Directorate, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyScientific Directorate, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyPhase 1 Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyPhase 1 Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyPhase 1 Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyScientific Directorate, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyMultidisciplinary Breast Center, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyComprehensive Cancer Center, UOC di Oncologia Medica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyGynecology and Breast Care Center, Mater Olbia Hospital, 07026 Olbia, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyScientific Directorate, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyScientific Directorate, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyBreast cancer represents the first cause of cancer worldwide and the leading cause of cancer mortality for women. Therefore, new therapies are needed to improve the prognosis of women diagnosed with this disease. In this review, we summarize the new drug indications for the treatment of breast cancer approved by European Medicines Agency between January 2015 and June 2021. In particular, we analyzed the clinical trials results leading to approvals and their update (when available), according to setting (localized and locally advanced or metastatic) and clinical features (hormone receptor positive, HER2 positive, triple negative, BRCA 1/2 mutation). The aim of this paper is to describe the clinical benefit obtained with the new indications.https://www.mdpi.com/2072-6694/13/20/5198breast cancerdrugs approvalEMA |
| spellingShingle | Simona Duranti Alessandra Fabi Marco Filetti Rosa Falcone Pasquale Lombardi Gennaro Daniele Gianluca Franceschini Luisa Carbognin Antonella Palazzo Giorgia Garganese Ida Paris Giovanni Scambia Antonella Pietragalla Breast Cancer Drug Approvals Issued by EMA: A Review of Clinical Trials Cancers breast cancer drugs approval EMA |
| title | Breast Cancer Drug Approvals Issued by EMA: A Review of Clinical Trials |
| title_full | Breast Cancer Drug Approvals Issued by EMA: A Review of Clinical Trials |
| title_fullStr | Breast Cancer Drug Approvals Issued by EMA: A Review of Clinical Trials |
| title_full_unstemmed | Breast Cancer Drug Approvals Issued by EMA: A Review of Clinical Trials |
| title_short | Breast Cancer Drug Approvals Issued by EMA: A Review of Clinical Trials |
| title_sort | breast cancer drug approvals issued by ema a review of clinical trials |
| topic | breast cancer drugs approval EMA |
| url | https://www.mdpi.com/2072-6694/13/20/5198 |
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