Vancomycin resistant enterococcus spp (VRE): follow up during 9 years in a tertiary teaching hospital in southern Brazil
Introduction: Infection with vancomycin-resistant Enterococcus spp (VRE) has been a worldwide problem since mid 1980's and, in Brazil, since 1996. This study was conducted to evaluate the experience with VRE in our institution. Methods: A prospective cohort study from 2000 to 2009 was conducte...
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| Format: | Article |
| Language: | English |
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Hospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS)
2015-01-01
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| Series: | Clinical and Biomedical Research |
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| Online Access: | http://seer.ufrgs.br/hcpa/article/view/50891 |
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| author | Ana Maria Sandri Geórgia Lopes da Silva Sílvia Pedroso Tavares Soares Fabiano Ramos Luciana Ruschel de Alcântara Larissa Lutz Afonso Luís Barth |
| author_facet | Ana Maria Sandri Geórgia Lopes da Silva Sílvia Pedroso Tavares Soares Fabiano Ramos Luciana Ruschel de Alcântara Larissa Lutz Afonso Luís Barth |
| author_sort | Ana Maria Sandri |
| collection | DOAJ |
| description | Introduction: Infection with vancomycin-resistant Enterococcus spp (VRE) has been a worldwide problem since mid 1980's and, in Brazil, since 1996. This study was conducted to evaluate the experience with VRE in our institution.
Methods: A prospective cohort study from 2000 to 2009 was conducted at Hospital São Lucas da PUCRS. All hospitalized patients with VRE positive culture were included and followed from their diagnosis until they were negative for VRE or their discharge. Only the first admission for each VRE positive patient was included. Pulsed field gel electrophoresis (PFGE) was performed to determine how VRE had spread.
Results: A total of 315 cases of VRE were identified, 224 of which were isolated from rectal swabs. Vancomycin-resistant/ampicilin susceptible Enterococcus faecalis were identified in 312 isolates. PFGE was performed in 47 VRE isolates that presented an indistinguishable migratory profile. The median length of hospital stay and length of stay before VRE isolation were 46 days and 21 days, respectively; 52% of the patients were aged 60 and above. The annual distribution of the new VRE cases showed a clear decrease from 2000 to 2009.
Discussion: This study shows a substantial VRE colonization (71%) with a homogenous pattern that emphasizes its transversal spread. Predominance of E. faecalis differs from the literature which largely describes a higher prevalence of vancomycin-resistant Enterococcus faecium . The follow up of VRE during 9 years in our institution highlighted the importance of continuous surveillance to prevent outbreaks in our hospital. |
| first_indexed | 2024-04-12T08:04:17Z |
| format | Article |
| id | doaj.art-50e84a09c5bf4faa9d35b1404031287f |
| institution | Directory Open Access Journal |
| issn | 0101-5575 2357-9730 |
| language | English |
| last_indexed | 2024-04-12T08:04:17Z |
| publishDate | 2015-01-01 |
| publisher | Hospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS) |
| record_format | Article |
| series | Clinical and Biomedical Research |
| spelling | doaj.art-50e84a09c5bf4faa9d35b1404031287f2022-12-22T03:41:13ZengHospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS)Clinical and Biomedical Research0101-55752357-97302015-01-0134426621Vancomycin resistant enterococcus spp (VRE): follow up during 9 years in a tertiary teaching hospital in southern BrazilAna Maria Sandri0Geórgia Lopes da Silva1Sílvia Pedroso Tavares Soares2Fabiano Ramos3Luciana Ruschel de Alcântara4Larissa Lutz5Afonso Luís Barth6Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do SulHospital São Lucas da Pontifícia Universidade Católica do Rio Grande do SulHospital São Lucas da Pontifícia Universidade Católica do Rio Grande do SulHospital São Lucas da Pontifícia Universidade Católica do Rio Grande do SulSecretaria Municipal da Saúde de Santa Cruz do SulHospital de Clínicas de Porto AlegreHospital de Clínicas de Porto Alegre Universidade Federal do Rio Grande do SulIntroduction: Infection with vancomycin-resistant Enterococcus spp (VRE) has been a worldwide problem since mid 1980's and, in Brazil, since 1996. This study was conducted to evaluate the experience with VRE in our institution. Methods: A prospective cohort study from 2000 to 2009 was conducted at Hospital São Lucas da PUCRS. All hospitalized patients with VRE positive culture were included and followed from their diagnosis until they were negative for VRE or their discharge. Only the first admission for each VRE positive patient was included. Pulsed field gel electrophoresis (PFGE) was performed to determine how VRE had spread. Results: A total of 315 cases of VRE were identified, 224 of which were isolated from rectal swabs. Vancomycin-resistant/ampicilin susceptible Enterococcus faecalis were identified in 312 isolates. PFGE was performed in 47 VRE isolates that presented an indistinguishable migratory profile. The median length of hospital stay and length of stay before VRE isolation were 46 days and 21 days, respectively; 52% of the patients were aged 60 and above. The annual distribution of the new VRE cases showed a clear decrease from 2000 to 2009. Discussion: This study shows a substantial VRE colonization (71%) with a homogenous pattern that emphasizes its transversal spread. Predominance of E. faecalis differs from the literature which largely describes a higher prevalence of vancomycin-resistant Enterococcus faecium . The follow up of VRE during 9 years in our institution highlighted the importance of continuous surveillance to prevent outbreaks in our hospital.http://seer.ufrgs.br/hcpa/article/view/50891Vancomycin-resistant EnterococcusVREoutbreaksurveillance. |
| spellingShingle | Ana Maria Sandri Geórgia Lopes da Silva Sílvia Pedroso Tavares Soares Fabiano Ramos Luciana Ruschel de Alcântara Larissa Lutz Afonso Luís Barth Vancomycin resistant enterococcus spp (VRE): follow up during 9 years in a tertiary teaching hospital in southern Brazil Clinical and Biomedical Research Vancomycin-resistant Enterococcus VRE outbreak surveillance. |
| title | Vancomycin resistant enterococcus spp (VRE): follow up during 9 years in a tertiary teaching hospital in southern Brazil |
| title_full | Vancomycin resistant enterococcus spp (VRE): follow up during 9 years in a tertiary teaching hospital in southern Brazil |
| title_fullStr | Vancomycin resistant enterococcus spp (VRE): follow up during 9 years in a tertiary teaching hospital in southern Brazil |
| title_full_unstemmed | Vancomycin resistant enterococcus spp (VRE): follow up during 9 years in a tertiary teaching hospital in southern Brazil |
| title_short | Vancomycin resistant enterococcus spp (VRE): follow up during 9 years in a tertiary teaching hospital in southern Brazil |
| title_sort | vancomycin resistant enterococcus spp vre follow up during 9 years in a tertiary teaching hospital in southern brazil |
| topic | Vancomycin-resistant Enterococcus VRE outbreak surveillance. |
| url | http://seer.ufrgs.br/hcpa/article/view/50891 |
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