Updates of Genomics and Proteomics of Parathyroid Carcinoma
Parathyroid carcinoma is a rare disease that needs an additional diagnostic tool and wide therapeutic options. The genomics and proteomics approach may help to find the tools to improve the prognosis of the disease by early detection and metastatic control. The findings from genomics were mainly <...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Endocrines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-396X/3/4/61 |
| _version_ | 1797459903266160640 |
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| author | Sung Hye Kong |
| author_facet | Sung Hye Kong |
| author_sort | Sung Hye Kong |
| collection | DOAJ |
| description | Parathyroid carcinoma is a rare disease that needs an additional diagnostic tool and wide therapeutic options. The genomics and proteomics approach may help to find the tools to improve the prognosis of the disease by early detection and metastatic control. The findings from genomics were mainly <i>CDC73</i>, <i>PRUNE2</i>, <i>CCND1</i>, and genes related to PI3K/AKT/mTOR and Wnt pathways. <i>CDC73</i>, <i>PRUNE2</i>, and <i>CCND1</i> were closely related to each other, and <i>PRUNE2</i> and <i>CCND1</i> genes are related to expression levels of parafibromin protein, which may aid in supporting the definite diagnosis of the disease. PI3K/AKT/mTOR and Wnt pathways could be a potential therapeutic target for the disease, which needs further basket trials to prove the concept. In this review, current findings from genomics and proteomics studies in parathyroid carcinoma were reviewed. |
| first_indexed | 2024-03-09T16:57:34Z |
| format | Article |
| id | doaj.art-50e9f082742b4c6aa5c518b353073fbf |
| institution | Directory Open Access Journal |
| issn | 2673-396X |
| language | English |
| last_indexed | 2024-03-09T16:57:34Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Endocrines |
| spelling | doaj.art-50e9f082742b4c6aa5c518b353073fbf2023-11-24T14:33:29ZengMDPI AGEndocrines2673-396X2022-11-013474575210.3390/endocrines3040061Updates of Genomics and Proteomics of Parathyroid CarcinomaSung Hye Kong0Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Republic of KoreaParathyroid carcinoma is a rare disease that needs an additional diagnostic tool and wide therapeutic options. The genomics and proteomics approach may help to find the tools to improve the prognosis of the disease by early detection and metastatic control. The findings from genomics were mainly <i>CDC73</i>, <i>PRUNE2</i>, <i>CCND1</i>, and genes related to PI3K/AKT/mTOR and Wnt pathways. <i>CDC73</i>, <i>PRUNE2</i>, and <i>CCND1</i> were closely related to each other, and <i>PRUNE2</i> and <i>CCND1</i> genes are related to expression levels of parafibromin protein, which may aid in supporting the definite diagnosis of the disease. PI3K/AKT/mTOR and Wnt pathways could be a potential therapeutic target for the disease, which needs further basket trials to prove the concept. In this review, current findings from genomics and proteomics studies in parathyroid carcinoma were reviewed.https://www.mdpi.com/2673-396X/3/4/61parathyroidcancergenomicsproteomics |
| spellingShingle | Sung Hye Kong Updates of Genomics and Proteomics of Parathyroid Carcinoma Endocrines parathyroid cancer genomics proteomics |
| title | Updates of Genomics and Proteomics of Parathyroid Carcinoma |
| title_full | Updates of Genomics and Proteomics of Parathyroid Carcinoma |
| title_fullStr | Updates of Genomics and Proteomics of Parathyroid Carcinoma |
| title_full_unstemmed | Updates of Genomics and Proteomics of Parathyroid Carcinoma |
| title_short | Updates of Genomics and Proteomics of Parathyroid Carcinoma |
| title_sort | updates of genomics and proteomics of parathyroid carcinoma |
| topic | parathyroid cancer genomics proteomics |
| url | https://www.mdpi.com/2673-396X/3/4/61 |
| work_keys_str_mv | AT sunghyekong updatesofgenomicsandproteomicsofparathyroidcarcinoma |