Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients

Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients

Plasmodium vivax is the major cause of human malaria in the Americas. How P. vivax infection can lead to poor clinical outcomes, despite low peripheral parasitaemia, remains a matter of intense debate. Estimation of total P. vivax biomass based on circulating markers indicates existence of a predomi...

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Bibliographic Details
Main Authors: João L Silva-Filho, João CK Dos-Santos, Carla Judice, Dario Beraldi, Kannan Venugopal, Diogenes Lima, Helder I Nakaya, Erich V De Paula, Stefanie CP Lopes, Marcus VG Lacerda, Matthias Marti, Fabio TM Costa
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
Plasmodium vivax
malaria parasite
total biomass
tissue infection
endothelial activation
haematopoiesis
Online Access:https://elifesciences.org/articles/71351

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