Green tea extract reduces insulin level and folliculogenesis in insulin-resistant PCOS rats model
Objectives: Polycystic ovary syndrome (PCOS) is an endocrine disorder with still unknown pathophysiology. Insulin resistance is one of major factors that affect the pathogenesis of PCOS (69%). Green tea has compounds that can be used to improve the condition of insulin resistance, so that folliculog...
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| Format: | Article |
| Language: | English |
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Universitas Airlangga
2020-01-01
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| Series: | Majalah Obstetri dan Ginekologi |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/MOG/article/view/17513 |
| _version_ | 1818601573599674368 |
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| author | Irma Maya Puspita Budi Santoso Budi Utomo |
| author_facet | Irma Maya Puspita Budi Santoso Budi Utomo |
| author_sort | Irma Maya Puspita |
| collection | DOAJ |
| description | Objectives: Polycystic ovary syndrome (PCOS) is an endocrine disorder with still unknown pathophysiology. Insulin resistance is one of major factors that affect the pathogenesis of PCOS (69%). Green tea has compounds that can be used to improve the condition of insulin resistance, so that folliculogenesis may recur in the case of PCOS.
Materials and Methods: The subjects in this study were rats which were divided into 5 groups, consisting of 2 groups serving as a control group (negative and positive) and 3 groups as the treatment group. Each group consisted of 7 experimental animals. Negative control group was given with distilled water for 14 days. Positive control group was given with injections of testosterone propionate 1 mg/100 g BW intramuscularly in the thigh for 28 days to obtain a model of insulin-resistant PCOS and the distilled water was used as therapy. The treatment groups were given wth injections of testosterone propionate 1 mg/100gBW intra-muscularly for 28 days and then treated with green tea extract in doses of each 200 mg/kg, 400 mg/kg, and 800 mg/kg for 14 days. Rats were dissected on day 42 for harvesting the right and left ovary and heart blood sample was taken for examining insulin levels.
Results: The results showed that administration of green tea extract on K5 can reduce insulin levels and increase folliculogenesis significantly (significance p <0.05).
Conclusion: Green tea extract can reduce insulin levels and increase folliculogenesis in rats. PCOS - Insulin resistance at a dose of 800 mg/kg. |
| first_indexed | 2024-12-16T12:53:32Z |
| format | Article |
| id | doaj.art-50eacfdbffa64d86abf7ffe26a1905bc |
| institution | Directory Open Access Journal |
| issn | 0854-0381 2598-1013 |
| language | English |
| last_indexed | 2024-12-16T12:53:32Z |
| publishDate | 2020-01-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Majalah Obstetri dan Ginekologi |
| spelling | doaj.art-50eacfdbffa64d86abf7ffe26a1905bc2022-12-21T22:31:06ZengUniversitas AirlanggaMajalah Obstetri dan Ginekologi0854-03812598-10132020-01-0127310310710.20473/mog.V27I32019.103-1078494Green tea extract reduces insulin level and folliculogenesis in insulin-resistant PCOS rats modelIrma Maya Puspita0Budi Santoso1Budi Utomo2Faculty of Health Sciences, Muhammadiyah University, SurabayaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, SurabayaDepartment of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, SurabayaObjectives: Polycystic ovary syndrome (PCOS) is an endocrine disorder with still unknown pathophysiology. Insulin resistance is one of major factors that affect the pathogenesis of PCOS (69%). Green tea has compounds that can be used to improve the condition of insulin resistance, so that folliculogenesis may recur in the case of PCOS. Materials and Methods: The subjects in this study were rats which were divided into 5 groups, consisting of 2 groups serving as a control group (negative and positive) and 3 groups as the treatment group. Each group consisted of 7 experimental animals. Negative control group was given with distilled water for 14 days. Positive control group was given with injections of testosterone propionate 1 mg/100 g BW intramuscularly in the thigh for 28 days to obtain a model of insulin-resistant PCOS and the distilled water was used as therapy. The treatment groups were given wth injections of testosterone propionate 1 mg/100gBW intra-muscularly for 28 days and then treated with green tea extract in doses of each 200 mg/kg, 400 mg/kg, and 800 mg/kg for 14 days. Rats were dissected on day 42 for harvesting the right and left ovary and heart blood sample was taken for examining insulin levels. Results: The results showed that administration of green tea extract on K5 can reduce insulin levels and increase folliculogenesis significantly (significance p <0.05). Conclusion: Green tea extract can reduce insulin levels and increase folliculogenesis in rats. PCOS - Insulin resistance at a dose of 800 mg/kg.https://e-journal.unair.ac.id/MOG/article/view/17513green teainsulin levelsfolliculogenesispolycystic ovary syndrome |
| spellingShingle | Irma Maya Puspita Budi Santoso Budi Utomo Green tea extract reduces insulin level and folliculogenesis in insulin-resistant PCOS rats model Majalah Obstetri dan Ginekologi green tea insulin levels folliculogenesis polycystic ovary syndrome |
| title | Green tea extract reduces insulin level and folliculogenesis in insulin-resistant PCOS rats model |
| title_full | Green tea extract reduces insulin level and folliculogenesis in insulin-resistant PCOS rats model |
| title_fullStr | Green tea extract reduces insulin level and folliculogenesis in insulin-resistant PCOS rats model |
| title_full_unstemmed | Green tea extract reduces insulin level and folliculogenesis in insulin-resistant PCOS rats model |
| title_short | Green tea extract reduces insulin level and folliculogenesis in insulin-resistant PCOS rats model |
| title_sort | green tea extract reduces insulin level and folliculogenesis in insulin resistant pcos rats model |
| topic | green tea insulin levels folliculogenesis polycystic ovary syndrome |
| url | https://e-journal.unair.ac.id/MOG/article/view/17513 |
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