Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial
(1) Background: Remimazolam is a novel benzodiazepine that prevents postoperative nausea and vomiting (PONV), is more effective than volatile anesthetics, and was recently approved for use in Japan. (2) Methods: This prospective, double-blind, randomized controlled trial study aimed to compare the e...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/16/5402 |
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| author | Ayumu Matsumoto Shiho Satomi Nami Kakuta Soshi Narasaki Yukari Toyota Hirotsugu Miyoshi Yousuke T. Horikawa Noboru Saeki Katsuya Tanaka Yasuo M. Tsutsumi |
| author_facet | Ayumu Matsumoto Shiho Satomi Nami Kakuta Soshi Narasaki Yukari Toyota Hirotsugu Miyoshi Yousuke T. Horikawa Noboru Saeki Katsuya Tanaka Yasuo M. Tsutsumi |
| author_sort | Ayumu Matsumoto |
| collection | DOAJ |
| description | (1) Background: Remimazolam is a novel benzodiazepine that prevents postoperative nausea and vomiting (PONV), is more effective than volatile anesthetics, and was recently approved for use in Japan. (2) Methods: This prospective, double-blind, randomized controlled trial study aimed to compare the efficacy of remimazolam and propofol as general anesthetics in terms of the incidence of PONV after laparoscopic gynecological surgery (UMIN000046237). High-risk female patients who underwent general anesthesia with either remimazolam or propofol for the maintenance of anesthesia were enrolled. The primary outcome was the incidence of PONV in the two groups (i.e., REM versus PROP) 2 h and 24 h after surgery. The incidence of vomiting without nausea, rescue antiemetic use, and the severity of nausea were also evaluated. (3) Results: No significant differences in PONV were identified between the REM and PROP groups at 2 h or 24 h. Furthermore, no differences were observed in any of the measured parameters, and no adverse events were reported. (4) Conclusions: The results of the present study suggest that remimazolam may be as effective as propofol in preventing PONV; however, further investigation is necessary to identify possible differences between these two agents. |
| first_indexed | 2024-03-09T10:55:12Z |
| format | Article |
| id | doaj.art-50eb4eee3eb8433890ea3d0216574e55 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T10:55:12Z |
| publishDate | 2023-08-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-50eb4eee3eb8433890ea3d0216574e552023-12-01T01:44:22ZengMDPI AGJournal of Clinical Medicine2077-03832023-08-011216540210.3390/jcm12165402Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled TrialAyumu Matsumoto0Shiho Satomi1Nami Kakuta2Soshi Narasaki3Yukari Toyota4Hirotsugu Miyoshi5Yousuke T. Horikawa6Noboru Saeki7Katsuya Tanaka8Yasuo M. Tsutsumi9Department of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Anesthesiology, Tokushima University, Tokushima 770-8503, JapanDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Anesthesiology, Tokushima University, Tokushima 770-8503, JapanDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima 734-8553, Japan(1) Background: Remimazolam is a novel benzodiazepine that prevents postoperative nausea and vomiting (PONV), is more effective than volatile anesthetics, and was recently approved for use in Japan. (2) Methods: This prospective, double-blind, randomized controlled trial study aimed to compare the efficacy of remimazolam and propofol as general anesthetics in terms of the incidence of PONV after laparoscopic gynecological surgery (UMIN000046237). High-risk female patients who underwent general anesthesia with either remimazolam or propofol for the maintenance of anesthesia were enrolled. The primary outcome was the incidence of PONV in the two groups (i.e., REM versus PROP) 2 h and 24 h after surgery. The incidence of vomiting without nausea, rescue antiemetic use, and the severity of nausea were also evaluated. (3) Results: No significant differences in PONV were identified between the REM and PROP groups at 2 h or 24 h. Furthermore, no differences were observed in any of the measured parameters, and no adverse events were reported. (4) Conclusions: The results of the present study suggest that remimazolam may be as effective as propofol in preventing PONV; however, further investigation is necessary to identify possible differences between these two agents.https://www.mdpi.com/2077-0383/12/16/5402remimazolamPONVgeneral anesthesia |
| spellingShingle | Ayumu Matsumoto Shiho Satomi Nami Kakuta Soshi Narasaki Yukari Toyota Hirotsugu Miyoshi Yousuke T. Horikawa Noboru Saeki Katsuya Tanaka Yasuo M. Tsutsumi Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial Journal of Clinical Medicine remimazolam PONV general anesthesia |
| title | Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial |
| title_full | Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial |
| title_fullStr | Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial |
| title_full_unstemmed | Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial |
| title_short | Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial |
| title_sort | remimazolam s effects on postoperative nausea and vomiting are similar to those of propofol after laparoscopic gynecological surgery a randomized controlled trial |
| topic | remimazolam PONV general anesthesia |
| url | https://www.mdpi.com/2077-0383/12/16/5402 |
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