Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow
Surface functionalization of materials to improve their hemocompatibility is a challenging problem in the field of blood-contacting devices and implants. Polyelectrolyte multilayer films (PEMs), which can mimic functions and structure of an extracellular matrix (ECM), are a promising solution to the...
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| Format: | Article |
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MDPI AG
2020-04-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/10/5/859 |
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| author | Gabriela Imbir Aldona Mzyk Klaudia Trembecka-Wójciga Ewa Jasek-Gajda Hanna Plutecka Romana Schirhagl Roman Major |
| author_facet | Gabriela Imbir Aldona Mzyk Klaudia Trembecka-Wójciga Ewa Jasek-Gajda Hanna Plutecka Romana Schirhagl Roman Major |
| author_sort | Gabriela Imbir |
| collection | DOAJ |
| description | Surface functionalization of materials to improve their hemocompatibility is a challenging problem in the field of blood-contacting devices and implants. Polyelectrolyte multilayer films (PEMs), which can mimic functions and structure of an extracellular matrix (ECM), are a promising solution to the urgent need for functional blood-contacting coatings. The properties of PEMs can be easily tuned in order to provide a scaffold with desired physico-chemical parameters. In this study chitosan/chondroitin sulfate (Chi/CS) polyelectrolyte multilayers were deposited on medical polyurethane. Afterwards PEMs were modified by chemical cross-linking and nanoparticles introduction. Coatings with variable properties were tested for their hemocompatibility in the cone-plate tester under dynamic conditions. The obtained results enable the understanding of how substrate properties modulate PEMs interaction with blood plasma proteins and the morphotic elements. |
| first_indexed | 2024-03-10T20:09:23Z |
| format | Article |
| id | doaj.art-50eb6dd228be47eeb46bc2057a4931cb |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T20:09:23Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-50eb6dd228be47eeb46bc2057a4931cb2023-11-19T23:01:53ZengMDPI AGNanomaterials2079-49912020-04-0110585910.3390/nano10050859Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood FlowGabriela Imbir0Aldona Mzyk1Klaudia Trembecka-Wójciga2Ewa Jasek-Gajda3Hanna Plutecka4Romana Schirhagl5Roman Major6Institute of Metallurgy and Materials Science, Polish Academy of Sciences, 25 Reymonta Street, 30-059 Krakow, PolandInstitute of Metallurgy and Materials Science, Polish Academy of Sciences, 25 Reymonta Street, 30-059 Krakow, PolandInstitute of Metallurgy and Materials Science, Polish Academy of Sciences, 25 Reymonta Street, 30-059 Krakow, PolandDepartment of Histology, Jagiellonian University Medical College, 7a Kopernika Street, 31-034 Krakow, PolandDepartment of Medicine, Jagiellonian University Medical College, 8 Skawinska Street, 31-066 Krakow, PolandDepartment of Biomedical Engineering, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The NetherlandsInstitute of Metallurgy and Materials Science, Polish Academy of Sciences, 25 Reymonta Street, 30-059 Krakow, PolandSurface functionalization of materials to improve their hemocompatibility is a challenging problem in the field of blood-contacting devices and implants. Polyelectrolyte multilayer films (PEMs), which can mimic functions and structure of an extracellular matrix (ECM), are a promising solution to the urgent need for functional blood-contacting coatings. The properties of PEMs can be easily tuned in order to provide a scaffold with desired physico-chemical parameters. In this study chitosan/chondroitin sulfate (Chi/CS) polyelectrolyte multilayers were deposited on medical polyurethane. Afterwards PEMs were modified by chemical cross-linking and nanoparticles introduction. Coatings with variable properties were tested for their hemocompatibility in the cone-plate tester under dynamic conditions. The obtained results enable the understanding of how substrate properties modulate PEMs interaction with blood plasma proteins and the morphotic elements.https://www.mdpi.com/2079-4991/10/5/859polyelectrolyte multilayer filmsblood-material interactionnatural heart valvesurface functionalization |
| spellingShingle | Gabriela Imbir Aldona Mzyk Klaudia Trembecka-Wójciga Ewa Jasek-Gajda Hanna Plutecka Romana Schirhagl Roman Major Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow Nanomaterials polyelectrolyte multilayer films blood-material interaction natural heart valve surface functionalization |
| title | Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow |
| title_full | Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow |
| title_fullStr | Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow |
| title_full_unstemmed | Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow |
| title_short | Polyelectrolyte Multilayer Films Modification with Ag and rGO Influences Platelets Activation and Aggregate Formation under In Vitro Blood Flow |
| title_sort | polyelectrolyte multilayer films modification with ag and rgo influences platelets activation and aggregate formation under in vitro blood flow |
| topic | polyelectrolyte multilayer films blood-material interaction natural heart valve surface functionalization |
| url | https://www.mdpi.com/2079-4991/10/5/859 |
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