Targeting PIM Kinases Affects Maintenance of CD133 Tumor Cell Population in Hepatoblastoma

Targeting PIM Kinases Affects Maintenance of CD133 Tumor Cell Population in Hepatoblastoma

Hepatoblastoma is the most common primary liver tumor in children, but treatment has not changed significantly in the past 20 years. We have previously demonstrated that Proviral Integration site for Moloney murine leukemia (PIM) kinases promote tumorigenesis in hepatoblastoma. Stem cell-like cancer...

Full description

Bibliographic Details
Main Authors:	Laura L. Stafman, Adele P. Williams, Evan F. Garner, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Kimberly Whelan, Elizabeth A. Beierle
Format:	Article
Language:	English
Published:	Elsevier 2019-02-01
Series:	Translational Oncology
Online Access:	http://www.sciencedirect.com/science/article/pii/S1936523318304327

Similar Items

PIM kinases mediate resistance to cisplatin chemotherapy in hepatoblastoma
by: Raoud Marayati, et al.
Published: (2021-03-01)

PIM Kinase Inhibition Attenuates the Malignant Progression of Metastatic Hepatoblastoma
by: Janet R. Julson, et al.
Published: (2023-12-01)

The Role of PIM Kinases in Pediatric Solid Tumors
by: Janet Rae Julson, et al.
Published: (2022-07-01)

Investigation of PP2A and Its Endogenous Inhibitors in Neuroblastoma Cell Survival and Tumor Growth
by: Adele P. Williams, et al.
Published: (2019-01-01)

Targeting Focal Adhesion Kinase Suppresses the Malignant Phenotype in Rhabdomyosarcoma Cells
by: Alicia M. Waters, et al.
Published: (2016-08-01)

FTY720 Decreases Tumorigenesis in Group 3 Medulloblastoma Patient-Derived Xenografts
by: Evan F. Garner, et al.
Published: (2018-05-01)

PIM Kinases in Multiple Myeloma
by: Jian Wu, et al.
Published: (2021-08-01)

UAB30, A Novel Rexinoid Agonist, Decreases Stemness In Group 3 Medulloblastoma Human Cell Line Xenografts
by: Adele P. Williams, et al.
Published: (2019-10-01)

EZH2 inhibition decreases neuroblastoma proliferation and in vivo tumor growth.
by: Laura V Bownes, et al.
Published: (2021-01-01)

Structure and substrate specificity of the Pim-1 kinase.
by: Bullock, A, et al.
Published: (2005)

Structure and substrate specificity of the Pim-1 kinase
by: Bullock, A, et al.
Published: (2005)

Pim Kinases: Important Regulators of Cardiovascular Disease
by: Sophie Nock, et al.
Published: (2023-07-01)

Targeting PIM Kinases to Improve the Efficacy of Immunotherapy
by: Amber N. Clements, et al.
Published: (2022-11-01)

Cell Proliferation in Neuroblastoma
by: Laura L. Stafman, et al.
Published: (2016-01-01)

Hepatoblastoma
by: Raùl Pichardo-Bahena, et al.
Published: (2005-04-01)

Ruthenium half-sandwich complexes bound to protein kinase Pim-1.
by: Debreczeni, J, et al.
Published: (2006)

Ruthenium half-sandwich complexes bound to protein kinase Pim-1
by: Debreczeni, J, et al.
Published: (2006)

Irinotecan as a maintenance therapy in relapsed Hepatoblastoma-a case report
by: Vimal Kumar, et al.
Published: (2017-10-01)

Irinotecan as a maintenance therapy in relapsed Hepatoblastoma- a case report
by: Dr. Dhanalakshmi, et al.
Published: (2016-01-01)

An overview of pim kinase as a target in multiple myeloma
by: Zhaoyun Liu, et al.
Published: (2023-05-01)

Expression and ERG regulation of PIM kinases in prostate cancer
by: Sini K. Eerola, et al.
Published: (2021-05-01)

IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes
by: Olivia J. James, et al.
Published: (2021-07-01)

Human CD180 Transmits Signals via the PIM-1L Kinase.
by: Nicole Egli, et al.
Published: (2015-01-01)

Adult hepatoblastoma
by: Javier A. Cienfuegos, et al.

‘Teratoid’ Hepatoblastoma: An Intriguing Variant of Mixed Epithelial-Mesenchymal Hepatoblastoma
by: Consolato M. Sergi, et al.
Published: (2022-04-01)

Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.
by: Bullock, A, et al.
Published: (2009)

Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family.
by: Bataille, C, et al.
Published: (2017)

PIM Kinases as Potential Biomarkers and Therapeutic Targets in Inflammatory Arthritides
by: Elisa Assirelli, et al.
Published: (2024-03-01)

Stabilization of PIM Kinases in Hypoxia Is Mediated by the Deubiquitinase USP28
by: Rachel K. Toth, et al.
Published: (2022-03-01)

Pim-2 Kinase Regulates Energy Metabolism in Multiple Myeloma
by: Zhaoyun Liu, et al.
Published: (2022-12-01)

Targeting Pim kinases in hematological cancers: molecular and clinical review
by: Marcia Bellon, et al.
Published: (2023-01-01)

Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.
by: Alex N Bullock, et al.
Published: (2009-10-01)

Proteasomes Are Critical for Maintenance of CD133+CD24+ Kidney Progenitor Cells
by: Sarmad Al-Marsoummi, et al.
Published: (2023-08-01)

Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors.
by: Akué-Gédu, R, et al.
Published: (2009)

PB1778: PAN-PIM KINASE INHIBITOR PIM447 SHOWS SUPERIOR ANTI-LEUKEMIC EFFECT IN ACUTE ERYTHROID LEUKEMIA
by: Chi-Yang Tseng, et al.
Published: (2023-08-01)

Protein Translation Inhibition is Involved in the Activity of the Pan-PIM Kinase Inhibitor PIM447 in Combination with Pomalidomide-Dexamethasone in Multiple Myeloma
by: Teresa Paíno, et al.
Published: (2020-09-01)

KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA.
by: Fang Cheng, et al.
Published: (2009-03-01)

Synthesis of Fused Quinoline Derivatives With Antiproliferative Activities and Tyrosine Kinases, Pim-1 Kinase Inhibitions
by: Rafat Milad Mohareb, et al.
Published: (2022-03-01)

PIM3 Kinase: A Promising Novel Target in Solid Cancers
by: Pinar Atalay, et al.
Published: (2024-01-01)

PIM kinases regulate early human Th17 cell differentiation
by: Tanja Buchacher, et al.
Published: (2023-12-01)