The Usefulness of Lymphadenectomy in Bladder Cancer—Current Status
The purpose of this review is to present the current status of lymph node dissection (LND) during radical cystectomy in patients with bladder cancer (BCa). Despite the growing body of evidence of LND utility at the time of radical cystectomy (RC) in high-risk nonmuscle-invasive and muscle-invasive B...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/5/415 |
| _version_ | 1797536378596098048 |
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| author | Bartosz Małkiewicz Paweł Kiełb Adam Gurwin Klaudia Knecht Karol Wilk Jakub Dobruch Romuald Zdrojowy |
| author_facet | Bartosz Małkiewicz Paweł Kiełb Adam Gurwin Klaudia Knecht Karol Wilk Jakub Dobruch Romuald Zdrojowy |
| author_sort | Bartosz Małkiewicz |
| collection | DOAJ |
| description | The purpose of this review is to present the current status of lymph node dissection (LND) during radical cystectomy in patients with bladder cancer (BCa). Despite the growing body of evidence of LND utility at the time of radical cystectomy (RC) in high-risk nonmuscle-invasive and muscle-invasive BCa (MIBC), therapeutic and prognostic value and optimal extent of LND remain unsolved issues. Recently published results of the first prospective, a randomized trial assessing the therapeutic benefit of extended versus limited LND during RC, failed to demonstrate survival improvement with the extended template. Although LND is the most accurate staging procedure, the direct therapeutic effect is still not evident from the current literature, limiting the possibility of establishing clear recommendations. This indicates the need for robust and adequately powered clinical trials. |
| first_indexed | 2024-03-10T11:59:47Z |
| format | Article |
| id | doaj.art-50ec25b18f514a7fa070b455355badc6 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T11:59:47Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-50ec25b18f514a7fa070b455355badc62023-11-21T17:02:29ZengMDPI AGMedicina1010-660X1648-91442021-04-0157541510.3390/medicina57050415The Usefulness of Lymphadenectomy in Bladder Cancer—Current StatusBartosz Małkiewicz0Paweł Kiełb1Adam Gurwin2Klaudia Knecht3Karol Wilk4Jakub Dobruch5Romuald Zdrojowy6Department of Urology and Oncologic Urology, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Urology and Oncologic Urology, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Urology and Oncologic Urology, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Urology and Oncologic Urology, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Urology and Oncologic Urology, Wroclaw Medical University, 50-556 Wroclaw, PolandFirst Department of Urology, Centre of Postgraduate Medical Education, 01-813 Warsaw, PolandDepartment of Urology and Oncologic Urology, Wroclaw Medical University, 50-556 Wroclaw, PolandThe purpose of this review is to present the current status of lymph node dissection (LND) during radical cystectomy in patients with bladder cancer (BCa). Despite the growing body of evidence of LND utility at the time of radical cystectomy (RC) in high-risk nonmuscle-invasive and muscle-invasive BCa (MIBC), therapeutic and prognostic value and optimal extent of LND remain unsolved issues. Recently published results of the first prospective, a randomized trial assessing the therapeutic benefit of extended versus limited LND during RC, failed to demonstrate survival improvement with the extended template. Although LND is the most accurate staging procedure, the direct therapeutic effect is still not evident from the current literature, limiting the possibility of establishing clear recommendations. This indicates the need for robust and adequately powered clinical trials.https://www.mdpi.com/1648-9144/57/5/415bladder cancersurgerylymph node dissectionlymphadenectomystaging |
| spellingShingle | Bartosz Małkiewicz Paweł Kiełb Adam Gurwin Klaudia Knecht Karol Wilk Jakub Dobruch Romuald Zdrojowy The Usefulness of Lymphadenectomy in Bladder Cancer—Current Status Medicina bladder cancer surgery lymph node dissection lymphadenectomy staging |
| title | The Usefulness of Lymphadenectomy in Bladder Cancer—Current Status |
| title_full | The Usefulness of Lymphadenectomy in Bladder Cancer—Current Status |
| title_fullStr | The Usefulness of Lymphadenectomy in Bladder Cancer—Current Status |
| title_full_unstemmed | The Usefulness of Lymphadenectomy in Bladder Cancer—Current Status |
| title_short | The Usefulness of Lymphadenectomy in Bladder Cancer—Current Status |
| title_sort | usefulness of lymphadenectomy in bladder cancer current status |
| topic | bladder cancer surgery lymph node dissection lymphadenectomy staging |
| url | https://www.mdpi.com/1648-9144/57/5/415 |
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