Antibacterial Fluorinated Diamond-like Carbon Coating Promotes Osteogenesis—Comparison with Titanium Alloy
Fluorinated diamond-like carbon (F-DLC) coating is biologically safe, provides superior antibacterial properties, and shows promise in preventing postoperative peri-implant infections. However, potential negative effects of this coating on in vivo bone formation and resorption have not been studied....
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MDPI AG
2021-10-01
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| author | Takeshi Sasamoto Masahito Kawaguchi Katsutaka Yonezawa Toru Ichiseki Ayumi Kaneuji Kazuhiro Shintani Anzu Yoshida Norio Kawahara |
| author_facet | Takeshi Sasamoto Masahito Kawaguchi Katsutaka Yonezawa Toru Ichiseki Ayumi Kaneuji Kazuhiro Shintani Anzu Yoshida Norio Kawahara |
| author_sort | Takeshi Sasamoto |
| collection | DOAJ |
| description | Fluorinated diamond-like carbon (F-DLC) coating is biologically safe, provides superior antibacterial properties, and shows promise in preventing postoperative peri-implant infections. However, potential negative effects of this coating on in vivo bone formation and resorption have not been studied. The authors investigated the effects of F-DLC coatings on bone union in beagle dogs. Seventy-two solid columns of titanium alloy were prepared with equally spaced slits. Half of these columns were coated with F-DLC (Group F), and the others were left uncoated as controls (Group C). Columns were implanted in the femurs of beagle dogs, and in vivo bone formation and resorption were assessed 4, 8, and 12 weeks after implantation. In comparison to Group C, Group F showed significantly greater bone volume and trabecular thickness at Week 8 (<i>p</i> < 0.05) and Week 12 (<i>p</i> < 0.005) and significantly lower bone resorption activity, measured by the ratio of osteoclasts to bone surface and of eroded surface to bone surface, at Week 12 (<i>p</i> < 0.05). The F-DLC coating encouraged bone formation in vivo more effectively than uncoated titanium alloy, suggesting that F-DLC will prove to be a useful coating material for antibacterial intraosseous implants. |
| first_indexed | 2024-03-10T06:45:16Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T06:45:16Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
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| series | Applied Sciences |
| spelling | doaj.art-50eca57850cb4e7a913c436267f2c3ec2023-11-22T17:18:51ZengMDPI AGApplied Sciences2076-34172021-10-011120945110.3390/app11209451Antibacterial Fluorinated Diamond-like Carbon Coating Promotes Osteogenesis—Comparison with Titanium AlloyTakeshi Sasamoto0Masahito Kawaguchi1Katsutaka Yonezawa2Toru Ichiseki3Ayumi Kaneuji4Kazuhiro Shintani5Anzu Yoshida6Norio Kawahara7Department of Orthopedic Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku 920-0293, JapanDepartment of Orthopedic Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku 920-0293, JapanDepartment of Orthopedic Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku 920-0293, JapanDepartment of Orthopedic Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku 920-0293, JapanDepartment of Orthopedic Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku 920-0293, JapanDepartment of Mechanical Engineering, Kanazawa Institute of Technology, 7-1 Ohgigaoka, Nonoichi 921-8501, JapanDepartment of Mechanical Engineering, Kanazawa Institute of Technology, 7-1 Ohgigaoka, Nonoichi 921-8501, JapanDepartment of Orthopedic Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku 920-0293, JapanFluorinated diamond-like carbon (F-DLC) coating is biologically safe, provides superior antibacterial properties, and shows promise in preventing postoperative peri-implant infections. However, potential negative effects of this coating on in vivo bone formation and resorption have not been studied. The authors investigated the effects of F-DLC coatings on bone union in beagle dogs. Seventy-two solid columns of titanium alloy were prepared with equally spaced slits. Half of these columns were coated with F-DLC (Group F), and the others were left uncoated as controls (Group C). Columns were implanted in the femurs of beagle dogs, and in vivo bone formation and resorption were assessed 4, 8, and 12 weeks after implantation. In comparison to Group C, Group F showed significantly greater bone volume and trabecular thickness at Week 8 (<i>p</i> < 0.05) and Week 12 (<i>p</i> < 0.005) and significantly lower bone resorption activity, measured by the ratio of osteoclasts to bone surface and of eroded surface to bone surface, at Week 12 (<i>p</i> < 0.05). The F-DLC coating encouraged bone formation in vivo more effectively than uncoated titanium alloy, suggesting that F-DLC will prove to be a useful coating material for antibacterial intraosseous implants.https://www.mdpi.com/2076-3417/11/20/9451F-DLC coatingantibacterial propertiesperi-implant infectionbone formationbone resorption |
| spellingShingle | Takeshi Sasamoto Masahito Kawaguchi Katsutaka Yonezawa Toru Ichiseki Ayumi Kaneuji Kazuhiro Shintani Anzu Yoshida Norio Kawahara Antibacterial Fluorinated Diamond-like Carbon Coating Promotes Osteogenesis—Comparison with Titanium Alloy Applied Sciences F-DLC coating antibacterial properties peri-implant infection bone formation bone resorption |
| title | Antibacterial Fluorinated Diamond-like Carbon Coating Promotes Osteogenesis—Comparison with Titanium Alloy |
| title_full | Antibacterial Fluorinated Diamond-like Carbon Coating Promotes Osteogenesis—Comparison with Titanium Alloy |
| title_fullStr | Antibacterial Fluorinated Diamond-like Carbon Coating Promotes Osteogenesis—Comparison with Titanium Alloy |
| title_full_unstemmed | Antibacterial Fluorinated Diamond-like Carbon Coating Promotes Osteogenesis—Comparison with Titanium Alloy |
| title_short | Antibacterial Fluorinated Diamond-like Carbon Coating Promotes Osteogenesis—Comparison with Titanium Alloy |
| title_sort | antibacterial fluorinated diamond like carbon coating promotes osteogenesis comparison with titanium alloy |
| topic | F-DLC coating antibacterial properties peri-implant infection bone formation bone resorption |
| url | https://www.mdpi.com/2076-3417/11/20/9451 |
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