Impact of non-motor fluctuations on QOL in patients with Parkinson’s disease
IntroductionLong-term levodopa treatment in patients with Parkinson’s disease (PwPD) often causes motor fluctuations, which are known to affect their quality of life (QOL). These motor fluctuations may be accompanied by fluctuations in non-motor symptoms. There is no consensus on how non-motor fluct...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1149615/full |
| _version_ | 1797845598838194176 |
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| author | Asako Kakimoto Asako Kakimoto Miki Kawazoe Kanako Kurihara Takayasu Mishima Yoshio Tsuboi |
| author_facet | Asako Kakimoto Asako Kakimoto Miki Kawazoe Kanako Kurihara Takayasu Mishima Yoshio Tsuboi |
| author_sort | Asako Kakimoto |
| collection | DOAJ |
| description | IntroductionLong-term levodopa treatment in patients with Parkinson’s disease (PwPD) often causes motor fluctuations, which are known to affect their quality of life (QOL). These motor fluctuations may be accompanied by fluctuations in non-motor symptoms. There is no consensus on how non-motor fluctuations affect QOL.MethodsThis was a single-center, retrospective study and included 375 patients with Parkinson’s disease (PwPD) who visited the neurology outpatient department of Fukuoka University Hospital between July 2015 and June 2018. All patients were evaluated for age, sex, disease duration, body weight, and motor symptoms by the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale part III, depression scale by the Zung self-rating depression scale, apathy scale, and cognitive function by the Japanese version of The Montreal Cognitive Assessment. A nine-item wearing-off questionnaire (WOQ-9) was used to assess the motor and non-motor fluctuations. QOL in PwPD was investigated using the eight-item Parkinson’s Disease Questionnaire (PDQ-8).ResultsIn total, 375 PwPD were enrolled and classified into three groups according to the presence or absence of motor and non-motor fluctuations. The first group included 98 (26.1%) patients with non-motor fluctuations (NFL group), the second group included 128 (34.1%) patients who presented with only motor fluctuations (MFL group), and the third group included 149 (39.7%) patients without fluctuations in motor or non-motor symptoms (NoFL group). Among them, the PDQ-8 SUM and SI were significantly higher in the NFL group than in the other groups (p < 0.005), implying that the NFL group had the poorest QOL among groups. Next, multivariable analysis showed that even one non-motor fluctuation was an independent factor that worsened QOL (p < 0.001).ConclusionThis study showed that PwPD with non-motor fluctuation had a lower QOL than those with no or only motor fluctuation. Moreover, the data showed that PDQ-8 scores were significantly reduced even with only one non-motor fluctuation. |
| first_indexed | 2024-04-09T17:41:37Z |
| format | Article |
| id | doaj.art-50ecb13123984d15a7d5042073f26b21 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-09T17:41:37Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-50ecb13123984d15a7d5042073f26b212023-04-17T04:25:14ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-04-011410.3389/fneur.2023.11496151149615Impact of non-motor fluctuations on QOL in patients with Parkinson’s diseaseAsako Kakimoto0Asako Kakimoto1Miki Kawazoe2Kanako Kurihara3Takayasu Mishima4Yoshio Tsuboi5Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, JapanDepartment of Neurology, Konishi Daiichi Hospital, Fukuoka, JapanDepartment of Preventive Medicine and Public Health, Fukuoka University, Fukuoka, JapanDepartment of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, JapanDepartment of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, JapanDepartment of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, JapanIntroductionLong-term levodopa treatment in patients with Parkinson’s disease (PwPD) often causes motor fluctuations, which are known to affect their quality of life (QOL). These motor fluctuations may be accompanied by fluctuations in non-motor symptoms. There is no consensus on how non-motor fluctuations affect QOL.MethodsThis was a single-center, retrospective study and included 375 patients with Parkinson’s disease (PwPD) who visited the neurology outpatient department of Fukuoka University Hospital between July 2015 and June 2018. All patients were evaluated for age, sex, disease duration, body weight, and motor symptoms by the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale part III, depression scale by the Zung self-rating depression scale, apathy scale, and cognitive function by the Japanese version of The Montreal Cognitive Assessment. A nine-item wearing-off questionnaire (WOQ-9) was used to assess the motor and non-motor fluctuations. QOL in PwPD was investigated using the eight-item Parkinson’s Disease Questionnaire (PDQ-8).ResultsIn total, 375 PwPD were enrolled and classified into three groups according to the presence or absence of motor and non-motor fluctuations. The first group included 98 (26.1%) patients with non-motor fluctuations (NFL group), the second group included 128 (34.1%) patients who presented with only motor fluctuations (MFL group), and the third group included 149 (39.7%) patients without fluctuations in motor or non-motor symptoms (NoFL group). Among them, the PDQ-8 SUM and SI were significantly higher in the NFL group than in the other groups (p < 0.005), implying that the NFL group had the poorest QOL among groups. Next, multivariable analysis showed that even one non-motor fluctuation was an independent factor that worsened QOL (p < 0.001).ConclusionThis study showed that PwPD with non-motor fluctuation had a lower QOL than those with no or only motor fluctuation. Moreover, the data showed that PDQ-8 scores were significantly reduced even with only one non-motor fluctuation.https://www.frontiersin.org/articles/10.3389/fneur.2023.1149615/fullParkinson’s diseasewearing-off phenomenonmotor fluctuationnon-motor fluctuationwearing-off questionnaire (WOQ-9)Parkinson’s disease questionnaire-8 (PDQ-8) |
| spellingShingle | Asako Kakimoto Asako Kakimoto Miki Kawazoe Kanako Kurihara Takayasu Mishima Yoshio Tsuboi Impact of non-motor fluctuations on QOL in patients with Parkinson’s disease Frontiers in Neurology Parkinson’s disease wearing-off phenomenon motor fluctuation non-motor fluctuation wearing-off questionnaire (WOQ-9) Parkinson’s disease questionnaire-8 (PDQ-8) |
| title | Impact of non-motor fluctuations on QOL in patients with Parkinson’s disease |
| title_full | Impact of non-motor fluctuations on QOL in patients with Parkinson’s disease |
| title_fullStr | Impact of non-motor fluctuations on QOL in patients with Parkinson’s disease |
| title_full_unstemmed | Impact of non-motor fluctuations on QOL in patients with Parkinson’s disease |
| title_short | Impact of non-motor fluctuations on QOL in patients with Parkinson’s disease |
| title_sort | impact of non motor fluctuations on qol in patients with parkinson s disease |
| topic | Parkinson’s disease wearing-off phenomenon motor fluctuation non-motor fluctuation wearing-off questionnaire (WOQ-9) Parkinson’s disease questionnaire-8 (PDQ-8) |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1149615/full |
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