Efficacy and Safety of a Novel Submucosal Injection Solution for Resection of Gastrointestinal Lesions
Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are minimally invasive and efficient techniques for the removal of gastrointestinal (GI) mucosal polyps. In both techniques, submucosal injection solutions are necessary for complete effectiveness and safety during the int...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/4/1162 |
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| author | Cristina Moles-Aranda Raquel González-Pérez Francisco Javier Gallego-Rojo Olga Martínez-Augustin Beatriz Clares-Naveros Fermín Sánchez de Medina José Antonio Morales-Molina |
| author_facet | Cristina Moles-Aranda Raquel González-Pérez Francisco Javier Gallego-Rojo Olga Martínez-Augustin Beatriz Clares-Naveros Fermín Sánchez de Medina José Antonio Morales-Molina |
| author_sort | Cristina Moles-Aranda |
| collection | DOAJ |
| description | Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are minimally invasive and efficient techniques for the removal of gastrointestinal (GI) mucosal polyps. In both techniques, submucosal injection solutions are necessary for complete effectiveness and safety during the intervention to be obtained. The main objective of this study was to evaluate the efficacy and safety of a new sterile submucosal injection solution for EMR/ESD used within a clinical protocol in patients with intestinal polyps. We carried out a prospective study between 2016 and 2017 with patients who attended the Endoscopy Consultation—Digestive Department of Primary Hospital. Patients were selected for EMR/ESD after the application of clinical protocols. Thirty-six patients were selected (≥ 66 years with comorbidities and risk factors). Lesions were located mainly in the colon. Our solution presented an intestinal lift ≥ 60 min in EMR/ESD and a high expansion of tissue, optimum viscosity, and subsequent complete resorption. The genes <i>S100A9</i> and <i>TP53</i> presented an expression increase in the distal regions. <i>TP53</i> and <i>PCNA</i> were the only genes whose expression was increased in polyp specimens vs. the surrounding tissue at the mRNA level. In EMR/ESD, our solution presented a prolonged effect at the intestinal level during all times of the intervention. Thus, our solution seems be an effective and safe alternative in cases of flat lesions in both techniques. |
| first_indexed | 2024-03-10T20:22:06Z |
| format | Article |
| id | doaj.art-50ee873ad7134add830e6fbd357e5246 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T20:22:06Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-50ee873ad7134add830e6fbd357e52462023-11-19T22:03:35ZengMDPI AGJournal of Clinical Medicine2077-03832020-04-0194116210.3390/jcm9041162Efficacy and Safety of a Novel Submucosal Injection Solution for Resection of Gastrointestinal LesionsCristina Moles-Aranda0Raquel González-Pérez1Francisco Javier Gallego-Rojo2Olga Martínez-Augustin3Beatriz Clares-Naveros4Fermín Sánchez de Medina5José Antonio Morales-Molina6Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Campus Universitario de Cartuja, 18071 Granada, SpainDepartment of Pharmacology, CIBERehd, Instituto de Investigación Biosanitaria ibs.GRANADA, School of Pharmacy, University of Granada, Campus Universitario de Cartuja, 18071 Granada, SpainDepartment of Digestive, Hospital de Poniente, Ctra. Almerimar, 04700 El Ejido, Almería, SpainInstituto de Investigación Biosanitaria ibs.GRANADA, University of Granada, 18071 Granada, SpainDepartment of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Campus Universitario de Cartuja, 18071 Granada, SpainDepartment of Pharmacology, CIBERehd, Instituto de Investigación Biosanitaria ibs.GRANADA, School of Pharmacy, University of Granada, Campus Universitario de Cartuja, 18071 Granada, SpainInstituto de Investigación Biosanitaria ibs.GRANADA, University of Granada, 18071 Granada, SpainEndoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are minimally invasive and efficient techniques for the removal of gastrointestinal (GI) mucosal polyps. In both techniques, submucosal injection solutions are necessary for complete effectiveness and safety during the intervention to be obtained. The main objective of this study was to evaluate the efficacy and safety of a new sterile submucosal injection solution for EMR/ESD used within a clinical protocol in patients with intestinal polyps. We carried out a prospective study between 2016 and 2017 with patients who attended the Endoscopy Consultation—Digestive Department of Primary Hospital. Patients were selected for EMR/ESD after the application of clinical protocols. Thirty-six patients were selected (≥ 66 years with comorbidities and risk factors). Lesions were located mainly in the colon. Our solution presented an intestinal lift ≥ 60 min in EMR/ESD and a high expansion of tissue, optimum viscosity, and subsequent complete resorption. The genes <i>S100A9</i> and <i>TP53</i> presented an expression increase in the distal regions. <i>TP53</i> and <i>PCNA</i> were the only genes whose expression was increased in polyp specimens vs. the surrounding tissue at the mRNA level. In EMR/ESD, our solution presented a prolonged effect at the intestinal level during all times of the intervention. Thus, our solution seems be an effective and safe alternative in cases of flat lesions in both techniques.https://www.mdpi.com/2077-0383/9/4/1162efficacysafetyendoscopic submucosal dissectionendoscopic mucosal resectiongastrointestinal endoscopysubmucosal injection |
| spellingShingle | Cristina Moles-Aranda Raquel González-Pérez Francisco Javier Gallego-Rojo Olga Martínez-Augustin Beatriz Clares-Naveros Fermín Sánchez de Medina José Antonio Morales-Molina Efficacy and Safety of a Novel Submucosal Injection Solution for Resection of Gastrointestinal Lesions Journal of Clinical Medicine efficacy safety endoscopic submucosal dissection endoscopic mucosal resection gastrointestinal endoscopy submucosal injection |
| title | Efficacy and Safety of a Novel Submucosal Injection Solution for Resection of Gastrointestinal Lesions |
| title_full | Efficacy and Safety of a Novel Submucosal Injection Solution for Resection of Gastrointestinal Lesions |
| title_fullStr | Efficacy and Safety of a Novel Submucosal Injection Solution for Resection of Gastrointestinal Lesions |
| title_full_unstemmed | Efficacy and Safety of a Novel Submucosal Injection Solution for Resection of Gastrointestinal Lesions |
| title_short | Efficacy and Safety of a Novel Submucosal Injection Solution for Resection of Gastrointestinal Lesions |
| title_sort | efficacy and safety of a novel submucosal injection solution for resection of gastrointestinal lesions |
| topic | efficacy safety endoscopic submucosal dissection endoscopic mucosal resection gastrointestinal endoscopy submucosal injection |
| url | https://www.mdpi.com/2077-0383/9/4/1162 |
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