Recombinant follitropin alfa/lutropin alfa in fertility treatment
Ahmed Gibreel1, Siladitya Bhattacharya21School of Medicine and Dentistry, University of Aberdeen; 2Aberdeen Maternity Hospital, Aberdeen, UKAbstract: Recombinant human follicle stimulating hormone (rFSH) and luteinizing hormone (LH), also known as follitropin alpha and lutropin alpha, are manufactur...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2009-12-01
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| Series: | Biologics: Targets & Therapy |
| Online Access: | http://www.dovepress.com/recombinant-follitropin-alfalutropin-alfa-in-fertility-treatment-a3873 |
| _version_ | 1818905638224265216 |
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| author | Ahmed Gibreel Siladitya Bhattacharya |
| author_facet | Ahmed Gibreel Siladitya Bhattacharya |
| author_sort | Ahmed Gibreel |
| collection | DOAJ |
| description | Ahmed Gibreel1, Siladitya Bhattacharya21School of Medicine and Dentistry, University of Aberdeen; 2Aberdeen Maternity Hospital, Aberdeen, UKAbstract: Recombinant human follicle stimulating hormone (rFSH) and luteinizing hormone (LH), also known as follitropin alpha and lutropin alpha, are manufactured by genetic engineering techniques which ensure high quality and batch to batch consistency. Follitropin alpha can be used for controlled ovarian hyperstimulation in assisted reproduction, ovulation induction for WHO group I and II anovulatory infertility and in men with hypogonadotrophic hypogonadism (HH) or idiopathic oligo-asthenospermia. Current evidence suggests superiority of urinary human menopausal gonadotropin (HMG) over follitropin alpha in controlled ovarian hyperstimulation for IVF in terms of live birth rate per couple. Addition of lutropin to follitropin alpha in an unselected IVF population does not appear to confer any benefit; however, it may have a role in ovulation induction in women with hypothalamic hypogonadism. Urinary HMG preparations (especially currently available highly purified preparations) are more cost effective than rFSH in terms of cost per ongoing pregnancy. However, women using rFSH injection pen devices have higher levels of satisfaction as compared to those using urinary HMG by means of conventional syringes.Keywords: infertility, follicle stimulating hormone, luteinizing hormone, follitropin alpha, lutropin alpha, in-vitro fertilization, urinary gonadotrophins |
| first_indexed | 2024-12-19T21:26:31Z |
| format | Article |
| id | doaj.art-50f02f170a2c485f8837827791fae2ac |
| institution | Directory Open Access Journal |
| issn | 1177-5475 1177-5491 |
| language | English |
| last_indexed | 2024-12-19T21:26:31Z |
| publishDate | 2009-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Biologics: Targets & Therapy |
| spelling | doaj.art-50f02f170a2c485f8837827791fae2ac2022-12-21T20:05:07ZengDove Medical PressBiologics: Targets & Therapy1177-54751177-54912009-12-012010default517Recombinant follitropin alfa/lutropin alfa in fertility treatmentAhmed GibreelSiladitya BhattacharyaAhmed Gibreel1, Siladitya Bhattacharya21School of Medicine and Dentistry, University of Aberdeen; 2Aberdeen Maternity Hospital, Aberdeen, UKAbstract: Recombinant human follicle stimulating hormone (rFSH) and luteinizing hormone (LH), also known as follitropin alpha and lutropin alpha, are manufactured by genetic engineering techniques which ensure high quality and batch to batch consistency. Follitropin alpha can be used for controlled ovarian hyperstimulation in assisted reproduction, ovulation induction for WHO group I and II anovulatory infertility and in men with hypogonadotrophic hypogonadism (HH) or idiopathic oligo-asthenospermia. Current evidence suggests superiority of urinary human menopausal gonadotropin (HMG) over follitropin alpha in controlled ovarian hyperstimulation for IVF in terms of live birth rate per couple. Addition of lutropin to follitropin alpha in an unselected IVF population does not appear to confer any benefit; however, it may have a role in ovulation induction in women with hypothalamic hypogonadism. Urinary HMG preparations (especially currently available highly purified preparations) are more cost effective than rFSH in terms of cost per ongoing pregnancy. However, women using rFSH injection pen devices have higher levels of satisfaction as compared to those using urinary HMG by means of conventional syringes.Keywords: infertility, follicle stimulating hormone, luteinizing hormone, follitropin alpha, lutropin alpha, in-vitro fertilization, urinary gonadotrophinshttp://www.dovepress.com/recombinant-follitropin-alfalutropin-alfa-in-fertility-treatment-a3873 |
| spellingShingle | Ahmed Gibreel Siladitya Bhattacharya Recombinant follitropin alfa/lutropin alfa in fertility treatment Biologics: Targets & Therapy |
| title | Recombinant follitropin alfa/lutropin alfa in fertility treatment |
| title_full | Recombinant follitropin alfa/lutropin alfa in fertility treatment |
| title_fullStr | Recombinant follitropin alfa/lutropin alfa in fertility treatment |
| title_full_unstemmed | Recombinant follitropin alfa/lutropin alfa in fertility treatment |
| title_short | Recombinant follitropin alfa/lutropin alfa in fertility treatment |
| title_sort | recombinant follitropin alfa lutropin alfa in fertility treatment |
| url | http://www.dovepress.com/recombinant-follitropin-alfalutropin-alfa-in-fertility-treatment-a3873 |
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